some news: new phase 0 trial for new radioligand gives good results

[Maxone73]

since I am in the waiting room waiting for my PET scan, I am making use of the time

”Unlike PSMA-targeted agents that are accompanied by an uptake in the lacrimal and salivary glands and in the renal tubules, which can lead to dose-limiting toxicity (20), targeting of hK2 with [111In]-DOTA-h11B6 showed no significant uptake in the salivary glands and a modest renal uptake (0.22–0.23 mGy/MBq); therefore, low radiation doses to these organs is expected”

But from what I read there is no accumulation in bones, but I do not understand if they mean healthy bones or bone metastasis. I suppose they mean healthy bones!

jnm.snmjournals.org/content...

[NickJoy]

Hope all goes well. Thank you for all of your helpful posts.

[KocoPr]

what kind of PET scan did you get Max?

[Maxone73 in reply to KocoPr]

18f-something-psma , every 6 months, plus bloodwork with PSA and testosterone this time, and next week my MO will tell me how I am doing!

[KocoPr in reply to Maxone73]

Good Luck with your results

[Maxone73 in reply to KocoPr]

Thanks!

[Ramp7]

All the best to you!

[Maxone73 in reply to Ramp7]

thanks!

[CousinGrandpa]

best wishes for a good report. The F18 is pylarify.

From pylarify.com:

PYLARIFY (piflufolastat F 18) Injection is a radioactive diagnostic agent indicated for positron emission tomography (PET) of prostate-specific membrane antigen (PSMA) positive lesions in men with prostate cancer:

with suspected metastasis who are candidates for initial definitive therapy.

with suspected recurrence based on elevated serum prostate-specific antigen (PSA) level.

[Maxone73 in reply to CousinGrandpa]

Thanks! I wish my metastasis were only suspected!

[MWPesaPharmD]

Don't be alarmed if the doc refers to the scan by another name (there are different brands (Pylarify and Posluma w/ F18) or even different names US vs EU (Pylarify vs Pylclari) - they all do a pretty phenomenal job. Best of luck with the results

[austinsurvivor]

great news! Been waiting for these results awhile

[john510185]

All the best Max! 👍

[j-o-h-n]

Beats being on the beach in the Bahamas, huh?

Good Luck, Good Health and Good Humor.

j-o-h-n

[Maxone73]

psa from 0.05 to 0.06 and testosterone from 0.33 to 0.5, both considered like normal fluctuations (hopefully), psma pet says I had more reduction of both bone and lymph nodes metastasis in size but especially in uptake….overall I was hoping for a miracle but MO is happy! 😜

[skiingfiend]

Don't sweat it, yet!

Hoping and praying everything is working out for you.

[Maxone73 in reply to skiingfiend]

Thanks, I truly appreciate it!

[Seasid]

Here’s a summary by AI (check for mistakes) of the current page:

New Target for Prostate Cancer: The page discusses the need for new treatments for metastatic castration-resistant prostate cancer (mCRPC) and introduces Human kallikrein 2 (hK2) as a novel target.

Phase 0 Trial: A first-in-human phase 0 trial using an 111 In-radiolabeled anti-hK2 monoclonal antibody, [ 111 In]-DOTA-h11B6, is described, which shows selective accumulation in mCRPC metastases.

Study Results: The study demonstrates that hK2 can be targeted for imaging and therapy, with the h11B6 antibody showing mass-independent clearance kinetics and limited uptake in non-target organs.

Potential for hK2-directed Therapies: The findings support the feasibility of hK2 as a target for imaging and potential therapies in patients with mCRPC, addressing the limitations of current treatments