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In vivo & in vitro: CRISPR 9 new approach to attack PCa proof of concept
The idea is to use the CRISPR technology to tweak prostate cancer cells so that they build up a specific type of compound (called porphyrins) that is usually harmless unless exposed to certain types of light. In people with a condition called porphyria, these porphyrins naturally build up because of
The idea is to use the CRISPR technology to tweak prostate cancer cells so that they build up a specific type of compound (called porphyrins) that is usually harmless unless exposed to certain types of light. In people with a condition called porphyria, these porphyrins naturally build up because of
Maxone73
in
Advanced Prostate Cancer
3 months ago
ok, last one before Christmas: AsiDNA (DT-01)
promising multi cancer Dbait (double-strand breaks (DSBs) family https://www.labiotech.eu/trends-news/onxeo-study-prostate-cancer-drug/ https://www.pharmaceutical-technology.com/data-insights/asidna-valerio-therapeutics-metastatic-castration-resistant-prostate-cancer-mcrpc-likelihood-of-approval-2/
promising multi cancer Dbait (double-strand breaks (DSBs) family https://www.labiotech.eu/trends-news/onxeo-study-prostate-cancer-drug/ https://www.pharmaceutical-technology.com/data-insights/asidna-valerio-therapeutics-metastatic-castration-resistant-prostate-cancer-mcrpc-likelihood-of-approval-2/
Maxone73
in
Advanced Prostate Cancer
7 months ago
PSA trippled since last Lupron infusion
My PSA was 0.05 between February 2023 and June 2023, then in September it ticked higher to 0.06 and at yesterday's Lupron injection it was 0.17. Should I be concerned? Anybody with similar experience: what did you do? Am I CR or still CS? Should I ask for Lu-177/Pluvicto ASAP? Thanks for reading.
My PSA was 0.05 between February 2023 and June 2023, then in September it ticked higher to 0.06 and at yesterday's Lupron injection it was 0.17. Should I be concerned? Anybody with similar experience: what did you do? Am I CR or still CS? Should I ask for Lu-177/Pluvicto ASAP? Thanks for reading.
Oldie68
in
Advanced Prostate Cancer
7 months ago
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happy holidays …. And a quick update
Just a quick note to wish all the warriors here a happy holidays with friends and family. As an update, I’m off all treatments and my psa remains <0.014. I remain grateful for the respite. My last degeralix injection and darolutamide was in May, and the SBRT to my ribs and neck about 2 years ago
Just a quick note to wish all the warriors here a happy holidays with friends and family. As an update, I’m off all treatments and my psa remains <0.014. I remain grateful for the respite. My last degeralix injection and darolutamide was in May, and the SBRT to my ribs and neck about 2 years ago
PGDuan
in
Advanced Prostate Cancer
7 months ago
Mylo Fibrosis, et al
I have been dealing with
skin
cancer
abut as long as PV/MF, so my Oncology team has discussed what, if anything, can be done to taper off the number of Squamous skin cancers, as I have been having 3-6 per year the last few years. Kind of a double whammy.
I have been dealing with
skin
cancer
abut as long as PV/MF, so my Oncology team has discussed what, if anything, can be done to taper off the number of Squamous skin cancers, as I have been having 3-6 per year the last few years. Kind of a double whammy.
luvinretirement
in
MPN Voice
1 year ago
Taking Meds in the AM vs PM
Hi I’m newly on Kisqali and Letrozole and I am wondering if anyone has feedback about whether it seems better to take these during the day or at night before bed. I’ve heard that some people prefer a nighttime dosage to sleep through any nausea or fatigue Interested in any and all experiences Thanks
Hi I’m newly on Kisqali and Letrozole and I am wondering if anyone has feedback about whether it seems better to take these during the day or at night before bed. I’ve heard that some people prefer a nighttime dosage to sleep through any nausea or fatigue Interested in any and all experiences Thanks
CatLoverinthe206
in
SHARE Metastatic Breast Cancer
3 months ago
Anyone participated in AMG 509 Clinical trial? - NCT04221542
Hello Please update us if you are participate in AMG 509. Anything you know about AMG 509 ? Study of AMG 509 in Participants With Metastatic Castration-Resistant Prostate Cancer
Hello Please update us if you are participate in AMG 509. Anything you know about AMG 509 ? Study of AMG 509 in Participants With Metastatic Castration-Resistant Prostate Cancer
God_Loves_Me
in
Advanced Prostate Cancer
3 months ago
chances of it being colon cancer
hi I am a 35 year old female and generally very healthy. the last 2 days I have noticed some bright red blood on the outside of my stool, not a lot just a couple of small specks. It is not mixed in with the stool and the stool is normal consistency amd colour. I am not suffering from abdominal pain
hi I am a 35 year old female and generally very healthy. the last 2 days I have noticed some bright red blood on the outside of my stool, not a lot just a couple of small specks. It is not mixed in with the stool and the stool is normal consistency amd colour. I am not suffering from abdominal pain
Glouise1234
in
Colon Cancer Connected
7 months ago
Phase 1 trial participation Nurix NX-1607
I have not been on any treatment since I stopped Docetaxel chemo last year except Prostap injections every 12 weeks. My PSA went up from ~9 to 20 from May to September. I have just been invited to take part in a phase 1a safety and tolerability study of NX-1607. It aims to inhibit CBL-B (Casitas B-lineage
I have not been on any treatment since I stopped Docetaxel chemo last year except Prostap injections every 12 weeks. My PSA went up from ~9 to 20 from May to September. I have just been invited to take part in a phase 1a safety and tolerability study of NX-1607. It aims to inhibit CBL-B (Casitas B-lineage
konichiwa12
in
Advanced Prostate Cancer
7 months ago
Radiation PSA, Orgovyx, Bone density
Rouge clone radiation on 10/31/23 has PSA continuing to drop to 0.85. MO plans to monitor PSA before requesting PSMA scan (insurance) unless it is increasing. Considering switch from Eligard to Orgovyx if PSA looks good in early Feb since Orgovyx apparently has less severe SE and doesn't tie me to
Rouge clone radiation on 10/31/23 has PSA continuing to drop to 0.85. MO plans to monitor PSA before requesting PSMA scan (insurance) unless it is increasing. Considering switch from Eligard to Orgovyx if PSA looks good in early Feb since Orgovyx apparently has less severe SE and doesn't tie me to
alperk
in
Advanced Prostate Cancer
7 months ago
Anybody experience post treatment bowel issues after being ok prior ?
Brachytherapy seeds early November , LINAC radiation boost ending early Jan .. ADT ending beginning March.. had space ore ..was totally ok except for urgency to pee sporadically.. other mild side effect and started to notice .. odd bowel issues.. one time had some gas and was careful but soon notice
Brachytherapy seeds early November , LINAC radiation boost ending early Jan .. ADT ending beginning March.. had space ore ..was totally ok except for urgency to pee sporadically.. other mild side effect and started to notice .. odd bowel issues.. one time had some gas and was careful but soon notice
Yokohama2023
in
Prostate Cancer Network
3 months ago
`psa level
I have now been on Firmagon (hormone therapy) for 23 months .I have stage 4+4 with an original PSA of 375.I had 6 rounds of chemo which killed off the majority of the cancer in bones and lungs.Only a couple of tiny spots in the lungs. My professor tells me i have had a very good result on many trips
I have now been on Firmagon (hormone therapy) for 23 months .I have stage 4+4 with an original PSA of 375.I had 6 rounds of chemo which killed off the majority of the cancer in bones and lungs.Only a couple of tiny spots in the lungs. My professor tells me i have had a very good result on many trips
Brianne07
in
Advanced Prostate Cancer
7 months ago
Embark Phase 3 clinical trial
Came across this today --- https://www.health.harvard.edu/blog/after-prostate-cancer-treatment-a-new-standard-of-care-for-rising-psa-202312203001
Came across this today --- https://www.health.harvard.edu/blog/after-prostate-cancer-treatment-a-new-standard-of-care-for-rising-psa-202312203001
chefjlu
in
Advanced Prostate Cancer
7 months ago
9 years - first detectable .012
Hi everyone, I’ve always been <.008. This time same lab I am .012. RP 2015, Gleason 7, not sure which primary number, no surgical margins, cancer in 2 quadrants, no lymph node invasion. I always go to the same lab here in Canada, LifeLabs. Have Uro appointment on Thursday. Any thoughts on what I might
Hi everyone, I’ve always been <.008. This time same lab I am .012. RP 2015, Gleason 7, not sure which primary number, no surgical margins, cancer in 2 quadrants, no lymph node invasion. I always go to the same lab here in Canada, LifeLabs. Have Uro appointment on Thursday. Any thoughts on what I might
Philosophy165
in
Advanced Prostate Cancer
3 months ago
Losing so much weight
My husband who has had his prostate removed, radiation, chemo, hormone therapy and 5 treatments of pluvicto (this is during 8 years) is now about to either get more radiation or chemo. He is just not eating and losing so much weight! I'm giving hime Ensure and whatever else he might eat but it's just
My husband who has had his prostate removed, radiation, chemo, hormone therapy and 5 treatments of pluvicto (this is during 8 years) is now about to either get more radiation or chemo. He is just not eating and losing so much weight! I'm giving hime Ensure and whatever else he might eat but it's just
LaRue44
in
Advanced Prostate Cancer
3 months ago
What happens when CT scan and ultrasound can't verify if it's an ovarian mass or not?
I (post-menopausal 52 y/o) went in to urgent care about a month ago with stomach pains. Doctor thought it was a ruptured appendix, but sent me for a CT scan to verify. Turns out it was diverticulitis, but on the CT scan they noticed a a complex cyst on my left ovary, however they couldn't be sure if
I (post-menopausal 52 y/o) went in to urgent care about a month ago with stomach pains. Doctor thought it was a ruptured appendix, but sent me for a CT scan to verify. Turns out it was diverticulitis, but on the CT scan they noticed a a complex cyst on my left ovary, however they couldn't be sure if
starrynight5626
in
My Ovacome
3 months ago
It wont be long
Hi All I have seen my Consultant today and she said it is time to start thinking about treatment. Not what I wanted to hear but after 14 years W&W I guessed it would come one day. She will arrange a CT Scan to check on Tumour burden (I think thats right) then just waiting on this. TP53 - deletion
Hi All I have seen my Consultant today and she said it is time to start thinking about treatment. Not what I wanted to hear but after 14 years W&W I guessed it would come one day. She will arrange a CT Scan to check on Tumour burden (I think thats right) then just waiting on this. TP53 - deletion
TheFlyer
in
CLL Support
3 months ago
Experience, thus far with Lupron and Abiraterone
I am 78 years old. I was diagnosed in May 2022 with PCa after my PSA was measured at 23.79. I have no other health issues. Following the determination that PCa was still within the prostrate capsule and had not spread to any other organ, I was placed on Lupron (6 monthly IM injections for 2 years). Clinically
I am 78 years old. I was diagnosed in May 2022 with PCa after my PSA was measured at 23.79. I have no other health issues. Following the determination that PCa was still within the prostrate capsule and had not spread to any other organ, I was placed on Lupron (6 monthly IM injections for 2 years). Clinically
Sanctus
in
Advanced Prostate Cancer
7 months ago
Hydroxyurea and skin cancer
I’m having trouble finding good information about the association between HU and
skin
cancer
, and also with the Interferons and
skin
cancer
. Can anyone provide insight or point me in the right direction? Thanks in advance!
I’m having trouble finding good information about the association between HU and
skin
cancer
, and also with the Interferons and
skin
cancer
. Can anyone provide insight or point me in the right direction? Thanks in advance!
Minify
in
MPN Voice
1 year ago
ONCT-534
Greetings, Recently I read that the FDA is now fast tracking this new drug— ONCT-534. Apparently it’s meant to follow-up on drugs such as Abiraterone and Xtandi once they have failed. I’m curious if anyone here is participating in the trial — phase1/2–and if anyone has any information outside of the
Greetings, Recently I read that the FDA is now fast tracking this new drug— ONCT-534. Apparently it’s meant to follow-up on drugs such as Abiraterone and Xtandi once they have failed. I’m curious if anyone here is participating in the trial — phase1/2–and if anyone has any information outside of the
Lavender22
in
Advanced Prostate Cancer
7 months ago
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