Taking Meds in the AM vs PM

[CatLoverinthe206]

Hi

I’m newly on Kisqali and Letrozole and I am wondering if anyone has feedback about whether it seems better to take these during the day or at night before bed. I’ve heard that some people prefer a nighttime dosage to sleep through any nausea or fatigue

Interested in any and all experiences

Thanks!

[Suite1000]

I'm on Ibrance which I take after dinner. I don't think I have any immediate side effects, but I began taking it in the evening just in case.

[Sharon0122]

I’m on Ibrance and antrozle, I take mine at night. I read somewhere the cancer is more active at night, so why not take aim when it’s up? Best to you hugs!

[seniorcitizen]

I take my Kisqali in the morning and have had very few issues with it. Side effects are so individual that is is difficult to come up with a general rule. (I am 77.)

[Artesa]

I take letrozole in the morning between 6:30-8am. I take Ibrance at 6pm on the dot, I use the alarm on my phone to ensure I am timely with it. The Salk Institute did a study on circadian rhythms with chemo and found it was most effective in the afternoon around 4pm . Most chemo is administered earlier in the day.

I decided to use 6pm knowing immunotherapy is not chemo but decided to go with this time anyway. Ibrance has a long half life and once you are on it for 8 days you have levels that are steady. In my mind, it seems like the time of day doesn't matter so much but there is too much that I don't know. I'm just guessing regarding the time of day I take it.

[Barbamams]

I always took them before bed to sleep through nausea. And it worked just fine!

[TammyCross]

It is recommended that Kisqali, unlike the other CDK4/6 inhibitors, be taken in the morning. I take it then and take exemestane at 1 pm, with some food. (I take everything with food unless that is prohibited. It is easier on the gut.) I tried morning, noon and night, but I think it causes insomnia. My oncologist suggested mid-day. Said it doesn't matter when, as long as it is consistent.