In vivo & in vitro: CRISPR 9 new appr... - Advanced Prostate...

Advanced Prostate Cancer

22,886 members28,492 posts

In vivo & in vitro: CRISPR 9 new approach to attack PCa proof of concept

Maxone73 profile image
0 Replies

The idea is to use the CRISPR technology to tweak prostate cancer cells so that they build up a specific type of compound (called porphyrins) that is usually harmless unless exposed to certain types of light.

In people with a condition called porphyria, these porphyrins naturally build up because of a genetic issue and can cause problems when the skin is exposed to sunlight. The researchers are trying to recreate this condition in cancer cells by shutting down a specific gene responsible for processing these compounds, causing the porphyrins to accumulate.

Once these compounds build up in the cancer cells, exposing them to a special light makes the porphyrins toxic to the cells, effectively killing them. This method targets only the cancer cells, leaving healthy cells unharmed. The experiments done in the lab and in mice have shown promising results, where the cancer cells die off after the light treatment.

cell.com/molecular-therapy-...

Written by
Maxone73 profile image
Maxone73
To view profiles and participate in discussions please or .
Read more about...

Not what you're looking for?

You may also like...

In vivo/vitro latest immunotherapy proof of concept by targeting IL30 in prostate cancer

Meanwhile in Italy, a group of researchers....this study discusses the development of...
Maxone73 profile image

New To PCa Notes - Part 2 of 2

The Beginning Of A Metastatic Prostate Cancer Journey - Part 2 of 2 22) A BIG QUESTION - at...

CRISPR 13 (what? you thought I abandoned CRISPR?): very promising proof of concept - Targeting HOXB13 in mPCa by CRISPR/Cas13d- nanoparticle

And people thought it was undruggable....they have already filed for a patent 😲 Researchers...
Maxone73 profile image

role of senescent cells in Pca

I am starting to see that there is new way of seeing how resistance forms, especially for those...
podsart profile image

Anti-aromatherapy?

New study below, from Duke [1]. It has been known for 20 years that the prostate has an olfactory...
pjoshea13 profile image