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Appropriate Treatment
I was diagnosed with stage 4 prostate cancer PSA 29.1 which had metastatised to lymph nodes, ribs & spine after a few months on Abiraterone and Prednisone my PSA count dropped to 0.06 After 30 months my PSA started to rise at 10.2 my treatment was declared ineffective Lutetium 177 treatment was recommended
I was diagnosed with stage 4 prostate cancer PSA 29.1 which had metastatised to lymph nodes, ribs & spine after a few months on Abiraterone and Prednisone my PSA count dropped to 0.06 After 30 months my PSA started to rise at 10.2 my treatment was declared ineffective Lutetium 177 treatment was recommended
154Eleventh
in
Advanced Prostate Cancer
3 months ago
10th year
Ten years ago I had my Gleason 9 prostate removed. PSA was .1 for a while. It crept up over .2, and I began taking lupron. The drug brought PSA back down to >.01 for a year or so. As the level started going up again, I received whole pelvis bed radiation, moving PSA to undetectable. After a year or so
Ten years ago I had my Gleason 9 prostate removed. PSA was .1 for a while. It crept up over .2, and I began taking lupron. The drug brought PSA back down to >.01 for a year or so. As the level started going up again, I received whole pelvis bed radiation, moving PSA to undetectable. After a year or so
Jvaughan0
in
Advanced Prostate Cancer
3 months ago
LATITUDE secondary analysis - Concurrent use of Abiraterone and NSAIDs - higher risk of Prostate Cancer Specific Mortality and inferior OS
https://doi.org/10.1200/JCO.2024.42.4_suppl.120 ”Conclusions: In this secondary analysis, concomitant exposure to 7 classes of medications was not associated with any statistically significant modification of abiraterone effect on OS in de novo high risk mHSPC. Men who received concurrent NSAIDs had
https://doi.org/10.1200/JCO.2024.42.4_suppl.120 ”Conclusions: In this secondary analysis, concomitant exposure to 7 classes of medications was not associated with any statistically significant modification of abiraterone effect on OS in de novo high risk mHSPC. Men who received concurrent NSAIDs had
Graham49
in
Advanced Prostate Cancer
5 months ago
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Improving Symptoms with Rising PSA
If prostate symptoms [i]
(less urinary frequency/less urgent urination/finally can sleep through night)
[/i] are improving, but PSA is increasing
(from 10 to15)
over last few years where at
10
MRI was negative, what does kind of pattern indicate or suggests?
If prostate symptoms [i]
(less urinary frequency/less urgent urination/finally can sleep through night)
[/i] are improving, but PSA is increasing
(from 10 to15)
over last few years where at
10
MRI was negative, what does kind of pattern indicate or suggests?
back2health
in
Advanced Prostate Cancer
3 months ago
Please help us decide on next treatment
Hi, my Dad was diagnosed back in 2021 with stage IV, Gleason 9, oligometastatic. He had 6 weeks of radiation at the time of diagnosis and has been for the past 2.5 years on Abiraterone, Prednisone and Lupron. As I mentioned in my prior post my Dad’s PSA started going up. He had a PSMA Pet scan and it
Hi, my Dad was diagnosed back in 2021 with stage IV, Gleason 9, oligometastatic. He had 6 weeks of radiation at the time of diagnosis and has been for the past 2.5 years on Abiraterone, Prednisone and Lupron. As I mentioned in my prior post my Dad’s PSA started going up. He had a PSMA Pet scan and it
Simonapo
in
Advanced Prostate Cancer
3 months ago
Agonists vs. antagonists (the latter not to be confused with a character in a novel!)
I know many of you on this site are beyond ADT, but for those who are still holding on in that space, I'd like to share my experience with the newer antagonists drugs, degarelix ( U.S. brand, Firmagon) and relugolix (U.S. brand, Orgovyx). I started ADT exactly 8 years ago this month and during my off-and-on
I know many of you on this site are beyond ADT, but for those who are still holding on in that space, I'd like to share my experience with the newer antagonists drugs, degarelix ( U.S. brand, Firmagon) and relugolix (U.S. brand, Orgovyx). I started ADT exactly 8 years ago this month and during my off-and-on
bluesnjazz
in
Advanced Prostate Cancer
5 months ago
A little Great News!
Hello Friends, A couple years ago our journey began. I was scared, panicked, and at a complete loss as my husband was diagnosed with stage 4 prostate cancer at age 49. He had 17 bone Mets. After some amazing input from this community and special advice from Tall Allen, I was able to set my sights
Hello Friends, A couple years ago our journey began. I was scared, panicked, and at a complete loss as my husband was diagnosed with stage 4 prostate cancer at age 49. He had 17 bone Mets. After some amazing input from this community and special advice from Tall Allen, I was able to set my sights
Lshanks07
in
Advanced Prostate Cancer
5 months ago
The MAO inhibitors phenelzine and clorgyline revert enzalutamide resistance in castration resistant prostate cancer
I am not using enza (yet) wondering if it's worth taking some nutmeg to keep those mao in check anyway! :-P https://www.nature.com/articles/s41467-020-15396-5
I am not using enza (yet) wondering if it's worth taking some nutmeg to keep those mao in check anyway! :-P https://www.nature.com/articles/s41467-020-15396-5
Maxone73
in
Fight Prostate Cancer
5 months ago
Skull Metastasis
I just received an order for a brain M RI from Dr. Aggarwal. I was wondering why. My recent PSMA PET scan an d probably confirmed by SPECT scans after Pluvicto show bone metastasis in my skull as well as in other bones (one of which has an SUV of 38) and which was quite painful before Pluvicto but has
I just received an order for a brain M RI from Dr. Aggarwal. I was wondering why. My recent PSMA PET scan an d probably confirmed by SPECT scans after Pluvicto show bone metastasis in my skull as well as in other bones (one of which has an SUV of 38) and which was quite painful before Pluvicto but has
spencoid2
in
Advanced Prostate Cancer
5 months ago
xtandi beginning to fail?
Seven months ago my PSA was 0.06. Three months ago PSA at my URO’s office was 0.11. I asked him if xtandi was beginning to fail me, he would not give me a answer. March 11th PSA at my MO’s office PSA was < 0.1. MO was happy with that number. I get checked again the 25th of this month at my URO. I
Seven months ago my PSA was 0.06. Three months ago PSA at my URO’s office was 0.11. I asked him if xtandi was beginning to fail me, he would not give me a answer. March 11th PSA at my MO’s office PSA was < 0.1. MO was happy with that number. I get checked again the 25th of this month at my URO. I
Echotango51
in
Advanced Prostate Cancer
3 months ago
Do you that have had Orchiectomy still take ATD Medication?
I’ve been told that I will be on ATD meds for life, I’m 63 and have been taking Lupron and Zytiga for going on two years. I asked my MO about Orchiectomy and he said if I did it he would still recommend Lupron. Can you guys please share your thoughts and experiences? Thank you in advance
I’ve been told that I will be on ATD meds for life, I’m 63 and have been taking Lupron and Zytiga for going on two years. I asked my MO about Orchiectomy and he said if I did it he would still recommend Lupron. Can you guys please share your thoughts and experiences? Thank you in advance
OldGuysRule
in
Advanced Prostate Cancer
5 months ago
PSA, total
Hello. I know this forum is about advanced prostate cancer. I’m really hoping I’m not there yet. I had a RP June 2023 I just got the results from my forth PSA test the first three were a post prostatectomy PSA test and all three were 0.02 this last one was a PSA, total. That’s what the Urologist wanted
Hello. I know this forum is about advanced prostate cancer. I’m really hoping I’m not there yet. I had a RP June 2023 I just got the results from my forth PSA test the first three were a post prostatectomy PSA test and all three were 0.02 this last one was a PSA, total. That’s what the Urologist wanted
Elkguide
in
Advanced Prostate Cancer
3 months ago
"Castration resistant"
What is the relevance of this term and how does one know if it applies to them? I am stage 4, three mets in the back for which I have already received radiation treatment along with same on prostate. I have had 2 Eligard shots and been on 500 mgs of Abiraterone plus 5mgs of prednisone daily. Can I
What is the relevance of this term and how does one know if it applies to them? I am stage 4, three mets in the back for which I have already received radiation treatment along with same on prostate. I have had 2 Eligard shots and been on 500 mgs of Abiraterone plus 5mgs of prednisone daily. Can I
GrantB47
in
Advanced Prostate Cancer
5 months ago
Lutetium - PSMA Earlier
For those members of this forum interested in the use of lutetium and where it 'fits' in the treatment of prostate cancer, this webinar from the [i]Prostate Theranostics Imaging Centre of Excellence[/i] and the [i]International Cancer Imagining Society[/i] is sure to be of interest. The discussion
For those members of this forum interested in the use of lutetium and where it 'fits' in the treatment of prostate cancer, this webinar from the [i]Prostate Theranostics Imaging Centre of Excellence[/i] and the [i]International Cancer Imagining Society[/i] is sure to be of interest. The discussion
marnieg46
in
Fight Prostate Cancer
5 months ago
PET Scan Results
Can anyone help me interpret my PET scan results from yesterday, and suggest possible courses of action? They seemed bad, but not disastrous. “Focal uptake in the right prostate bed (max SUV 5.3) as well as the right lesser trochanter (max SUV 4.5), not present on the prior study, suspicious for
Can anyone help me interpret my PET scan results from yesterday, and suggest possible courses of action? They seemed bad, but not disastrous. “Focal uptake in the right prostate bed (max SUV 5.3) as well as the right lesser trochanter (max SUV 4.5), not present on the prior study, suspicious for
Murph256
in
Advanced Prostate Cancer
5 months ago
prostap injections and alchol
hi does being on prostap injections make alcohol effect you more than it normally would please
hi does being on prostap injections make alcohol effect you more than it normally would please
Prettythings1
in
Endometriosis UK
10 months ago
In vitro but...fighting bone metastasis
Currently they have tested it on metastasis of breast cancer, but hopefully it could work for all bone metastasis https://www.eurekalert.org/news-releases/1032208
Currently they have tested it on metastasis of breast cancer, but hopefully it could work for all bone metastasis https://www.eurekalert.org/news-releases/1032208
Maxone73
in
Fight Prostate Cancer
5 months ago
Multi-Drug Combo May Be Best Against Prostate Cancer...I thought it was a known fact already!
"Combining two or three testosterone-blocking drugs prevents the spread of prostate cancer better than just a single medication, a new clinical trial has found." Dr Aggrawal again! https://www.usnews.com/news/health-news/articles/2024-01-25/multi-drug-combo-may-be-best-against-prostate-cancer
"Combining two or three testosterone-blocking drugs prevents the spread of prostate cancer better than just a single medication, a new clinical trial has found." Dr Aggrawal again! https://www.usnews.com/news/health-news/articles/2024-01-25/multi-drug-combo-may-be-best-against-prostate-cancer
Maxone73
in
Advanced Prostate Cancer
5 months ago
Abiraterone, Prednisone, Apalutamide combo Improves Prostate Cancer Outcomes, Leaves HRQoL Unaffected
Oncological outcomes improved with the addition of abiraterone acetate (Zytiga) plus prednisone (AAP) and apalutamide (Erleada) after radical prostatectomy and did not significantly affect health-related quality of life. https://www.targetedonc.com/view/abiraterone-prednisone-apalutamide-improves-prostate-cancer-outcomes-leaves-hrqol-unaffected
Oncological outcomes improved with the addition of abiraterone acetate (Zytiga) plus prednisone (AAP) and apalutamide (Erleada) after radical prostatectomy and did not significantly affect health-related quality of life. https://www.targetedonc.com/view/abiraterone-prednisone-apalutamide-improves-prostate-cancer-outcomes-leaves-hrqol-unaffected
Maxone73
in
Advanced Prostate Cancer
5 months ago
Thank god patients live longer, so we need new surrogate parameters to avoid slowing down research
As Patients Live Longer, New Criteria Needed for Prostate Cancer Trials https://news.feinberg.northwestern.edu/2024/01/25/as-patients-live-longer-new-criteria-needed-for-prostate-cancer-trials/
As Patients Live Longer, New Criteria Needed for Prostate Cancer Trials https://news.feinberg.northwestern.edu/2024/01/25/as-patients-live-longer-new-criteria-needed-for-prostate-cancer-trials/
Maxone73
in
Advanced Prostate Cancer
5 months ago
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