Lutetium - PSMA Earlier

[marnieg46]

For those members of this forum interested in the use of lutetium and where it 'fits' in the treatment of prostate cancer, this webinar from the Prostate Theranostics Imaging Centre of Excellence and the International Cancer Imagining Society is sure to be of interest.

The discussion will focus on the ground -breaking advancements in Lutetium -177 PSMA Theranostics, particularly its potential as an earlier line of therapy. A focus of the presentation will be the unpacking of the exciting findings of PSMAfore and ENZA-P trials by Professors Louise Emmett and Oliver Sartor. Both Louise and Oliver will provide comprehensive summaries and insights into these pivotal studies.

Additionally, the webinar will offer a unique platform for diverse perspectives from various Asian countries on the current applications and future of PSMA PET/CT and PSMA theranostics. It will provide the opportunity to hear from experts from many Asian countries and around the globe. Broadcast live from the GU Cast studio in Melbourne.

Note the different times for the various zones:

PSST 31 January - 18:00

ICT 1 February - 09:00

SGT 1 February - 10:00

KST 1 February - 11:00

AEST 1 February - 13:00

Register for this webinar at :

unimelb.zoom.us/webinar/reg...

[cujoe]

Marnie - Thanks for the advance heads-up on the webinar. I expect this will advance the info shared by Drs. Emmett and Sartor in the video interview you linked in an earlier post. In that interview, Dr. Emmett was very impressive and it seems she has firmly established herself as a leader in applied PSMA theranostics.

FWIW, at my late 2023 appointment with my MO, I asked about the cost for Pluvicto without insurance coverage (i.e., Hormone Sensitive status) and outside of a clinical trial and he quoted the round number of $100K. (I didn't ask if that was for a single treatment or a series, as in my case I wouldn't have made much difference!)

Give our best to Ron and Y'all Stay S&W. Ciao - Capt'n cujoe

[MateoBeach in reply to cujoe]

The cost of my very effective (so far) treatments with Lu-PSMA-J591 in Perth AU last year by Nat Lenzo was about $11,000 US for both doses and all associated care. Flights, hotels and meals were extra but amazing hospitality graciously and new friendships provided free.

[Purple-Bike in reply to MateoBeach]

Paul, do you know if there is anything published by now on the elimination of micromets following SBRT with the kind of treatment you had?Great that your pioneering treatment seems to be working!

[cujoe in reply to MateoBeach]

Paul - Thanks for providing some international (and personal) perspective on the availablility of PSMA theranostics for HS patients. It also illustrates that the "free-market" is more free in some parts of the world than it is in others.

Enjoy the sun, sand, and beach - while being and staying S&W, Ciao - cujoe

[Purple-Bike in reply to MateoBeach]

No worries about a study - Nat Lenzo told me data will be available in a couple of months. He invited me to a Zoom call......

Could you share something about in what way you have found the J591 treatments to be effective?

[MateoBeach in reply to Purple-Bike]

I had two doses of Lu-J591 in May 2022 (4 weeks after SBRT to 2 LNs). MY PSA dropped by 90% in first few months then continued to decline to non-detectable (<0.014) where it remains. So: Very effective!

[Purple-Bike in reply to MateoBeach]

Is it likely that most of the decline is due to LU-J591 and not SBRT?

[MateoBeach in reply to Purple-Bike]

It is believed to be the combo per Lenzo's ongoing trial.

[NPfisherman]

Hi Marnie,

Thanks for posting this information. As new treatments develop, there is the continued trend of moving it from MCRPC to the MHSPC patients. Would using Lutetium-PSMA earlier result in achieving a 50% survival rate for 5 years for Stage IV PCa?? I believe so...

Unfortunately, these things take time...

I'll sign up and see about watching some of these... I like Ollie and Louise..

DD

[marnieg46 in reply to NPfisherman]

Me too Dave. I think they both have a lot to offer.

Declan Murphy, (one of those involved) said in an email that the webinar will also eventually make its way onto his podcast. I'll post the link to that when it's up and running. Hope all goes well in WV.

[MateoBeach in reply to NPfisherman]

Well there you go, Sartor's brief presentation on PSMAFore and PSMA-DC make's the case (so far) to not wait. Sequence Lu177 before other systemic treatments. As long as renal function and blood counts are acceptable. (Hi Marnie ❤️)

[NPfisherman in reply to MateoBeach]

The only reason that we are forced to wait is the system... Oz pushing it to the MHSPC level just makes sense... If it works on resistant disease, how much better on the sensitive disease version... Such logic....shocking !!! Glad to hear that you are doing well after your treatment, and still running undetectable on the PSA..

DD

[marnieg46 in reply to MateoBeach]

G'day Paul. I thought something that was very interesting and encouraging at the end of Sartor's presentation was that he made a small reference to working towards finding ways to avoid ADT. I've just sent you an email re Michael Hofman..😘

[MateoBeach]

The PSMA-DC study Oliver Sartor described fits the treatment I had (except monoclonal antibidy J591) for oligometastatic hormone sensitive PC. Still no sign of failure with PSA undetectable. Hugs. Paul

[Purple-Bike]

Missed the webinar it was at 3 a.m. for me....

I wrote in my contact details to see the webinar now, but a password is required to access it. Do you know how to get around this? Or could you sum up what the conclusions are - the earlier LU-177 the better, before castration resistance and before chemo?

[marnieg46 in reply to Purple-Bike]

Hi Purple-Bike

The webinar is going to be on the podcast - GU Cast. I would think it won't be long before they post it. I will put up that link when it's available.

In an email today (see below) from Michael Hofman he included a link that will be available in a few days.

The recording will be available in a few days on our YouTube channel: youtube.com/c/ProsTICTV?sub...