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Olaparib
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olaparib
Just wondering if anyone has experience with
olaparib
? I now have metastases in my liver as well as bones. I started carboplatin chemo last week after failed docetaxel and carparvotaxel treatments.
Olaparib
has been mentioned as a possible treatment.
Just wondering if anyone has experience with
olaparib
? I now have metastases in my liver as well as bones. I started carboplatin chemo last week after failed docetaxel and carparvotaxel treatments.
Olaparib
has been mentioned as a possible treatment.
Luylu
in
Prostate Cancer Network
18 days ago
Precision Drug Olaparib May Be Effective Without Hormone Therapy for Some Men with Biochemically Recurrent Prostate Cancer
https://www.hopkinsmedicine.org/news/newsroom/news-releases/2024/08/precision-drug-
olaparib
-may-be-effective-without-hormone-therapy-for-some-men-with-biochemically-recurrent-prostate-cancer
https://www.hopkinsmedicine.org/news/newsroom/news-releases/2024/08/precision-drug-
olaparib
-may-be-effective-without-hormone-therapy-for-some-men-with-biochemically-recurrent-prostate-cancer
Maxone73
in
Advanced Prostate Cancer
3 days ago
Consider the options?
., one cycle of carboplatin (couldn't tolerate paclitaxel) and now on Avastin i/v and
Olaparib
. CA 9, which is fantastic. Side effects are just destroying me. I am 80, the
Olaparib
goes through to mid June 2026 and the Avastin finishes at the end of this year.
., one cycle of carboplatin (couldn't tolerate paclitaxel) and now on Avastin i/v and
Olaparib
. CA 9, which is fantastic. Side effects are just destroying me. I am 80, the
Olaparib
goes through to mid June 2026 and the Avastin finishes at the end of this year.
Pawpaw22
in
My Ovacome
2 months ago
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PARP inhibitor Olaparib, phase 3 study findings (PROpel)
While we wait for the next generation PARP inhibitors to become available (I have written about it few weeks ago and I will soon have some first hand data), here are the results of
Olaparib
+Abiraterone It actually has decent effect also for people with no HRR mutations, but it works at its best with
While we wait for the next generation PARP inhibitors to become available (I have written about it few weeks ago and I will soon have some first hand data), here are the results of
Olaparib
+Abiraterone It actually has decent effect also for people with no HRR mutations, but it works at its best with
Maxone73
in
Advanced Prostate Cancer
2 months ago
Update and question about Olaparib
Lots of info I know but would love to know if anyone has heard of or had experience with
Olaparib
.
Lots of info I know but would love to know if anyone has heard of or had experience with
Olaparib
.
Iwasborntodothis
in
SHARE Metastatic Breast Cancer
2 months ago
Olaparib time to lower PSA
Hello all, Anyone know how long it take for
Olaparib
ro lower PSA? All I can find is that it takes 90 days to start working. Thanks
Hello all, Anyone know how long it take for
Olaparib
ro lower PSA? All I can find is that it takes 90 days to start working. Thanks
Seebs9
in
Advanced Prostate Cancer
4 months ago
Update on side effects of Olaparib and Avastin
I am off the Avastin and the
Olaparib
. The side effects were growing daily. Now Watch and wait. I am so relieved. Two nights running, no sweats, no nightmares or vivid dreams, eagerly awaiting improvement in my ability to taste food and some more energy.
I am off the Avastin and the
Olaparib
. The side effects were growing daily. Now Watch and wait. I am so relieved. Two nights running, no sweats, no nightmares or vivid dreams, eagerly awaiting improvement in my ability to taste food and some more energy.
Pawpaw22
in
My Ovacome
2 months ago
blue lips side effect olaparib
I’ve just started
olaparib
maintenance therapy following debunking and chemo that finished in January. I have started to get blue lips. My only other side effects are joint pain (helped by onega 3 and exercise) and mild nausea. Has anyone else had blue lips? Is it serious?
I’ve just started
olaparib
maintenance therapy following debunking and chemo that finished in January. I have started to get blue lips. My only other side effects are joint pain (helped by onega 3 and exercise) and mild nausea. Has anyone else had blue lips? Is it serious?
Beatbigc
in
My Ovacome
4 months ago
update after 2 yrs on Lynparza and looking for suggestions...
2️⃣are there any known side effects of
olaparib
after 2 years of use? It took me 4 months to adjust to it and I am on a reduced dose. But not aware if there is any stated long term side effect of the drug.
2️⃣are there any known side effects of
olaparib
after 2 years of use? It took me 4 months to adjust to it and I am on a reduced dose. But not aware if there is any stated long term side effect of the drug.
Goodgirl98
in
My Ovacome
1 month ago
BRCAAWAY Trial: Abiraterone and Olaparib work way better together than sequentially in mCRPC for BRCA1/2 and ATM
So this is over three years median compared to the abiraterone arm, which was about eight and a half months, and then 14 months for the
olaparib
. " https://www.urotoday.com/video-lectures/asco-gu-2024/video/mediaitem/3865-brcaaway-trial-impact-of-abiraterone-and-
olaparib
-combination-in-prostate-cancer-maha-hussain.html
So this is over three years median compared to the abiraterone arm, which was about eight and a half months, and then 14 months for the
olaparib
. " https://www.urotoday.com/video-lectures/asco-gu-2024/video/mediaitem/3865-brcaaway-trial-impact-of-abiraterone-and-
olaparib
-combination-in-prostate-cancer-maha-hussain.html
Maxone73
in
Advanced Prostate Cancer
6 months ago
conflict of opinion
Am on Avastin and
Olaparib
. My CA125 is slowly decreasing but I am still somewhat concerned by the differing opinions x
Am on Avastin and
Olaparib
. My CA125 is slowly decreasing but I am still somewhat concerned by the differing opinions x
Beaver54
in
My Ovacome
5 months ago
This study indicates not enough metastatic PCa patients are having Next Generation Sequence testing (NGS)
For instance, in the PROfound (
Olaparib
[Lynparza] Versus Enzalutamide or Abiraterone Acetate in Men With mCRPC) trial, patients harboring HRR alterations who received
olaparib
had a 51% reduction in the risk of radiographic progression or death compared with those treated with the physician’s choice
For instance, in the PROfound (
Olaparib
[Lynparza] Versus Enzalutamide or Abiraterone Acetate in Men With mCRPC) trial, patients harboring HRR alterations who received
olaparib
had a 51% reduction in the risk of radiographic progression or death compared with those treated with the physician’s choice
Graham49
in
Advanced Prostate Cancer
24 days ago
lynparza / olaparib
hi everyone- my dad had progression to chest wall and his hip on ibrance after about 14 months on it so he switched to lynparza/
Olaparib
for MBC in October of 2023. He had a pet scan on 1/29 that showed a complete metabolic response.
hi everyone- my dad had progression to chest wall and his hip on ibrance after about 14 months on it so he switched to lynparza/
Olaparib
for MBC in October of 2023. He had a pet scan on 1/29 that showed a complete metabolic response.
Jenniferp2122
in
SHARE Metastatic Breast Cancer
6 months ago
Finishing Olaparib PARP after 2 years
I just wondered if any of you could share your experiences after ending
Olaparib
or another PARP. Have you had a recurrence or have you stayed NED?
I just wondered if any of you could share your experiences after ending
Olaparib
or another PARP. Have you had a recurrence or have you stayed NED?
Carpediem68
in
My Ovacome
5 months ago
How active were/are you with Olaparib (Lynparza)?
I started
Olaparib
today. I am supposed to start work at 40% 1st of May, and increase by 20% each month. I know that I could have some side effects with
Olaparib
, I would rather
NOT KNOW
so much about them as psychologically I usually develop all symptoms I think I should have.
I started
Olaparib
today. I am supposed to start work at 40% 1st of May, and increase by 20% each month. I know that I could have some side effects with
Olaparib
, I would rather
NOT KNOW
so much about them as psychologically I usually develop all symptoms I think I should have.
IsaStarr
in
My Ovacome
5 months ago
Feeling worried
Then
olaparib
for just 2 yrs then it stopped working. Ca125 started to creep up ( lymph nodes ) so back to chemo which seemed to work but 5 months later its back. Told carbo sensitive so started on Caelyx. Only 2 rounds but oncologist not happy ca125 rising rapidly so now on weekly paclitaxol.
Then
olaparib
for just 2 yrs then it stopped working. Ca125 started to creep up ( lymph nodes ) so back to chemo which seemed to work but 5 months later its back. Told carbo sensitive so started on Caelyx. Only 2 rounds but oncologist not happy ca125 rising rapidly so now on weekly paclitaxol.
Casamimosa
in
My Ovacome
2 months ago
Heading down hospice road too…
Next step was Lynparza (
olaparib
), started January 5 which left him a zombie, unable to eat, drink and it severely dropped his hemoglobin. He ended up in the hospital after 3 weeks on it for a blood clot in his leg and blood transfusion so
olaparib
was stopped.
Next step was Lynparza (
olaparib
), started January 5 which left him a zombie, unable to eat, drink and it severely dropped his hemoglobin. He ended up in the hospital after 3 weeks on it for a blood clot in his leg and blood transfusion so
olaparib
was stopped.
LJGD
in
Advanced Prostate Cancer
6 months ago
RSI type symptoms to wrists and thumbs
Had severe hyposensitivity reaction to docetaxel so looking at
olaparib
subject to gene testing. Coming off prednisalone gradually. Interested if anyone experienced similar issues with wrists and how long it lasted.
Had severe hyposensitivity reaction to docetaxel so looking at
olaparib
subject to gene testing. Coming off prednisalone gradually. Interested if anyone experienced similar issues with wrists and how long it lasted.
FortyWinks
in
Advanced Prostate Cancer
4 months ago
What next? re maintenance for HGS recurrence
Would love to know if any ladies who has also been unsuccessful with
Olaparib
, what has been a successful maintenance for you? I’ve just got 2 cycles more of Carbo/Caelyx, min scan showed slight reduction not as good as hoped for. Only maintenance mentioned by oncologist is to go on Letrozole.
Would love to know if any ladies who has also been unsuccessful with
Olaparib
, what has been a successful maintenance for you? I’ve just got 2 cycles more of Carbo/Caelyx, min scan showed slight reduction not as good as hoped for. Only maintenance mentioned by oncologist is to go on Letrozole.
Towergirl
in
My Ovacome
4 months ago
Gastric discomfort with Olaparib
I’m currently taking 300mg of
Olaparib
per day and am experiencing gastric discomfort and feelings of … .Wanting to burp but nothing happens .Something lodged in my food pipe (there isn’t and no problems with swallowing) . .
I’m currently taking 300mg of
Olaparib
per day and am experiencing gastric discomfort and feelings of … .Wanting to burp but nothing happens .Something lodged in my food pipe (there isn’t and no problems with swallowing) . .
Alfiepop
in
My Ovacome
5 months ago
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