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Olaparib
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Olaparib side effects?
Hi there ladies, I’ve been on
Olaparib
for around five - six weeks. I find I seem to get diarrhoea around every four days and my appetite has dropped right off ( feel slightly nauseous most of the time ). I’m still eating as much as I can but feel a bit low with it all at the moment.
Hi there ladies, I’ve been on
Olaparib
for around five - six weeks. I find I seem to get diarrhoea around every four days and my appetite has dropped right off ( feel slightly nauseous most of the time ). I’m still eating as much as I can but feel a bit low with it all at the moment.
Frenchhouse3
in
My Ovacome
5 years ago
NICE submission - your comments on olaparib and bevacizumab (Avastin) needed
Hello All You may remember I posted a while back about a submission we're making to NICE about making
olaparib
and bevacizumab (Avastin) available in combination as a maintenance therapy.
Hello All You may remember I posted a while back about a submission we're making to NICE about making
olaparib
and bevacizumab (Avastin) available in combination as a maintenance therapy.
OvacomeSupport
Administrator
in
My Ovacome
4 years ago
What now? Help for Taxman, please!
I read something about a PARP inhibitor- particularly
OLAPARIB
. Does anyone know anything more I can do w/o chemo and going to a facility until this mess is over. I live in NY and am currently "stuck" in Florida because of the virus. Can someone please help. Any suggestions?
I read something about a PARP inhibitor- particularly
OLAPARIB
. Does anyone know anything more I can do w/o chemo and going to a facility until this mess is over. I live in NY and am currently "stuck" in Florida because of the virus. Can someone please help. Any suggestions?
taxman
in
Advanced Prostate Cancer
4 years ago
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FDA Grants Priority Review to Olaparib for HRR-Mutant mCRPC - Targeted Oncology - January 20, 2020
A total of 16% of patients on who were treated with
olaparib
discontinued treatment due to AEs.
A total of 16% of patients on who were treated with
olaparib
discontinued treatment due to AEs.
cujoe
in
Fight Prostate Cancer
5 years ago
Olaparib
Hi, I am taking
Olaparib
doing fine up to now I’m taking it since last January 2019 I was initially given Avastin after my first round of chemotherapy, I had my first recurrence 21 months later, I’ve had two recurrences in total but because I just couldn’t take anymore chemotherapy I pushed for the
Olaparib
Hi, I am taking
Olaparib
doing fine up to now I’m taking it since last January 2019 I was initially given Avastin after my first round of chemotherapy, I had my first recurrence 21 months later, I’ve had two recurrences in total but because I just couldn’t take anymore chemotherapy I pushed for the
Olaparib
21752
in
OvaCare
5 years ago
Denise
Hi there, I’ve been on
Olaparib
for three weeks now and so far have only experienced mild nausea. However, I do have a very watery mouth some days which is quite unpleasant. Does anyone else have this side effect and is there anything that helps alleviate it? Denise
Hi there, I’ve been on
Olaparib
for three weeks now and so far have only experienced mild nausea. However, I do have a very watery mouth some days which is quite unpleasant. Does anyone else have this side effect and is there anything that helps alleviate it? Denise
Frenchhouse3
in
My Ovacome
5 years ago
Olaparib-capsules or tablets
I have just started on
olaparib
- 16 capsules a day which amounts to 800mg. I was just wondering if those who have been prescribed this are on tablets or capsules and if so why the difference. It is hard to swallow that amount daily. Rosie
I have just started on
olaparib
- 16 capsules a day which amounts to 800mg. I was just wondering if those who have been prescribed this are on tablets or capsules and if so why the difference. It is hard to swallow that amount daily. Rosie
Rosiemd
in
My Ovacome
5 years ago
Darolutamide vs Proxalutamide - for a Hail Mary??
After that, went to
Olaparib
(Lynparza) took care of liver mets but not PSA, so added Zytiga, and that worked very well for over 1-1/2 years - until last summer. MO took him off the Lynparza, and switched the steroid from prednisone to dexamethasone to get more time on Zytiga..
After that, went to
Olaparib
(Lynparza) took care of liver mets but not PSA, so added Zytiga, and that worked very well for over 1-1/2 years - until last summer. MO took him off the Lynparza, and switched the steroid from prednisone to dexamethasone to get more time on Zytiga..
JLS1
in
Advanced Prostate Cancer
5 years ago
NICE olaparib announcement today
Hello All This is to let you know NICE have announced today that
olaparib
will be available as second line maintenance treatment via the Cancer Drugs Fund, for those with the BRCA mutation.
Hello All This is to let you know NICE have announced today that
olaparib
will be available as second line maintenance treatment via the Cancer Drugs Fund, for those with the BRCA mutation.
OvacomeSupport
Administrator
in
My Ovacome
5 years ago
Travel Insurance for metastatic cancer
Hi everyone, My dad is doing well at the beginning of his treatment (on a Zytiga and a double-blind trail of
olaparib
). His PSA numbers dropped quick and he is feeling great. He wants to go on vacation but won't go without travel insurance.
Hi everyone, My dad is doing well at the beginning of his treatment (on a Zytiga and a double-blind trail of
olaparib
). His PSA numbers dropped quick and he is feeling great. He wants to go on vacation but won't go without travel insurance.
ArabianNights
in
Advanced Prostate Cancer
5 years ago
Survey on PARP Inhibitors
Hello All The National Centre for Pharmacoeconomics has completed a rapid review of
olaparib
for the treatment of ovarian cancer, as maintenance treatment following first line platinum-based chemotherapy .
Hello All The National Centre for Pharmacoeconomics has completed a rapid review of
olaparib
for the treatment of ovarian cancer, as maintenance treatment following first line platinum-based chemotherapy .
Ovacare2
OvaCare Team Member
in
OvaCare
5 years ago
Olaparib in Patients With Metastatic Castration-Resistant Prostate Cancer With DNA Repair Gene Aberrations
FINDINGS 711 patients consented for targeted screening between April 1, 2015, and Aug 30, 2018. 161 patients had DDR gene aberrations, 98 of whom were randomly assigned and treated (49 patients for each
olaparib
dose), with 92 evaluable for the primary endpoint (46 patients for each
olaparib
dose)
FINDINGS 711 patients consented for targeted screening between April 1, 2015, and Aug 30, 2018. 161 patients had DDR gene aberrations, 98 of whom were randomly assigned and treated (49 patients for each
olaparib
dose), with 92 evaluable for the primary endpoint (46 patients for each
olaparib
dose)
Balsam01
in
Advanced Prostate Cancer
5 years ago
Olaparib available first line in Scotland for BRCA+ women
There is more information on the SMC website here: https://www.scottishmedicines.org.uk/media/4953/decision-explained-
olaparib
-lynparza.pdf Best wishes Anna Ovacome Support
There is more information on the SMC website here: https://www.scottishmedicines.org.uk/media/4953/decision-explained-
olaparib
-lynparza.pdf Best wishes Anna Ovacome Support
OvacomeSupport
Administrator
in
My Ovacome
5 years ago
Met in c5 c6 :-(
Now on
Olaparib
off Xtandi ...psa rose to 4.8. But, met in C5 C6 area is really painful. Pain in my neck, left shoulder, arm and fingers are tingly. Very limited motion now in my left arm. CT scan showed narrowing ... thanks to my wonderful PCa onologist, I got into a neurosurgeon right away.
Now on
Olaparib
off Xtandi ...psa rose to 4.8. But, met in C5 C6 area is really painful. Pain in my neck, left shoulder, arm and fingers are tingly. Very limited motion now in my left arm. CT scan showed narrowing ... thanks to my wonderful PCa onologist, I got into a neurosurgeon right away.
Alvin735
in
Advanced Prostate Cancer
5 years ago
OLAPARIB
Doctor suggested to use
OLAPARIB
as gene test came positive. Anyone here used it or using it ? How effective is it ? We are from India. It's very costly here. Anyone know the way to get it in less price ?
Doctor suggested to use
OLAPARIB
as gene test came positive. Anyone here used it or using it ? How effective is it ? We are from India. It's very costly here. Anyone know the way to get it in less price ?
Ijkl
in
My Ovacome
5 years ago
Response to Olaparib Among Men With BRCA 1 / 2 or ATM Mutated Prostate Cancer
I hope this interview is attainable. https://www.practiceupdate.com/expertopinion/4329/67/11?elsca1=emc_enews_weekinreview&elsca2=email&elsca3=practiceupdate_advancedprostatecancer&elsca4=advancedprostatecancer&elsca5=newsletter&rid=MzQwNTM3NTczMjUxS0&lid=10332481
I hope this interview is attainable. https://www.practiceupdate.com/expertopinion/4329/67/11?elsca1=emc_enews_weekinreview&elsca2=email&elsca3=practiceupdate_advancedprostatecancer&elsca4=advancedprostatecancer&elsca5=newsletter&rid=MzQwNTM3NTczMjUxS0&lid=10332481
Balsam01
in
Advanced Prostate Cancer
5 years ago
Ovarian cancer 3c diagnosed in Jan 2017 joined icon 8b trial relapse dec 2018 6 chemo scheduled 5 completed. Started Olaparib May 2010 brca2
So they started me on
Olaparib
and scheduled the lumpectomy which I did in August 2019 back on
Olaparib
tough issues with fatigue reflux and constipation which they said would settle. And it has thank god. I’m on the strongest dose 8 capsule twice a day.
So they started me on
Olaparib
and scheduled the lumpectomy which I did in August 2019 back on
Olaparib
tough issues with fatigue reflux and constipation which they said would settle. And it has thank god. I’m on the strongest dose 8 capsule twice a day.
Rivervalley1
in
My Ovacome
5 years ago
PAOLA and PRIMA trials - your experiences
Your comments would be used to inform two NICE submissions, one about making
olaparib
plus bevacizumab available first line (which was studied on the PAOLA trial) and one about making niraparib available first line (which was studied on the PRIMA trial).
Your comments would be used to inform two NICE submissions, one about making
olaparib
plus bevacizumab available first line (which was studied on the PAOLA trial) and one about making niraparib available first line (which was studied on the PRIMA trial).
OvacomeSupport
Administrator
in
My Ovacome
5 years ago
Pembro and Olaparib clinical trial
Consult at Johns Hopkins offered Pembro and
Olaparib
combo clinical trial . I did not have BRCA1/2 or ATM gene mutations and not sure of efficacy of this trial for me. Have read of adverse effects of those on trial. Weighing pros/cons.
Consult at Johns Hopkins offered Pembro and
Olaparib
combo clinical trial . I did not have BRCA1/2 or ATM gene mutations and not sure of efficacy of this trial for me. Have read of adverse effects of those on trial. Weighing pros/cons.
PAQFAS
in
Advanced Prostate Cancer
5 years ago
Antitumor Activity Seen With Keytruda in mCRPC
inhibitor-based combination regimens have shown activity in mCRPC, including the CheckMate 650 trial of nivolumab (Opdivo) plus the CTLA-4 checkpoint inhibitor ipilimumab (Yervoy) and KEYNOTE-365, which showed promising antitumor activity and well-tolerated TRAEs when pembrolizumab was combined with
olaparib
inhibitor-based combination regimens have shown activity in mCRPC, including the CheckMate 650 trial of nivolumab (Opdivo) plus the CTLA-4 checkpoint inhibitor ipilimumab (Yervoy) and KEYNOTE-365, which showed promising antitumor activity and well-tolerated TRAEs when pembrolizumab was combined with
olaparib
snoraste
in
Advanced Prostate Cancer
5 years ago
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