Precision Drug Olaparib May Be Effective Without Hormone Therapy for Some Men with Biochemically Recurrent Prostate Cancer

[Maxone73]

Note: there is something better than olaparib that is being tested at the moment, something more precise and less toxic (saruparib)

but still this is a very interesting news for people with HRR mutations, especially BRCA 1/2 because they are proving that this approach can work even without a simultaneous ADT therapy...

hopkinsmedicine.org/news/ne...

[KocoPr]

That’s amazing! Any treatment to get of ADT would be much appreciated for us all!

[j-o-h-n]

saruparib. It would help if they reverse the name to birapuras which would make it easier to pronounce. Sknaht.

Good Luck, Good Health and Good Humor.

j-o-h-n

[MoonRocket]

Interesting that ATM responded since it is not widely accepted that the Parp Inhibitors have any impact outside of BRCA2.

[Maxone73 in reply to MoonRocket]

they do, but to a lesser extent. There is one pretty large study that says that parpi work also for people with no genetic alterations but to such a small extent that sometimes they are not worth it.

[MoonRocket in reply to Maxone73]

Which is why I ask which ATM mutation are detected. Not all ATM mutations are created equally and therefore only some respond. I wish this data was provided.

[Maxone73 in reply to MoonRocket]

I will try to see if the data are available

[Maxone73 in reply to MoonRocket]

I have found a big paywall...maybe they will be available for free soon

[Ian99]

Thanks for finding this. Am on Olaparib. Am getting results after 3 months but SEs are ever present and wear you down. Found this on saruparib..

onclive.com/view/first-in-c...

Looks encouraging.

[Hidden]

Very promising news, but I'm on a Facebook group for Olaparib and the side effects are pretty bad. I stopped chemo after 2 cycles, I could not handle it, these women say that they would rather do chemo instead.