BRCAAWAY Trial: Abiraterone and Olaparib work way better together than sequentially in mCRPC for BRCA1/2 and ATM

[Maxone73]

"The median progression-free survival was 39 months. So this is over three years median compared to the abiraterone arm, which was about eight and a half months, and then 14 months for the olaparib. "

urotoday.com/video-lectures...

[Jewelrylady]

thank you for sharing this. Can you also be on Lupron + abiraterone + prednisone for the olaparib to be added if you became castrate resistant.

[Maxone73 in reply to Jewelrylady]

I suppose so but this trial was not about that combination

[Seasid]

This is a really very small clinical trial and it doesn't provide any evidence about the overall survival (being a phase ii clinical trial).

I would be very reluctant to drow any conclusions from a small phase ii clinical trial.

The most important for me is the overall survival data. How long I am going to stay alive.

[Maxone73 in reply to Seasid]

And that's completely fine with me...maybe other people like the PFS prediction.

[Seasid in reply to Maxone73]

I still believe that parp inhibitors should be used as a last resort drug after everything else failed.

The reason is that they are very effective therefore we know that they will extend life no matter what, but also very toxic. Great after everything else failed.

[Seasid in reply to Maxone73]

Ok, I am happy with the trial just a warning don't use parp inhibitors first because you will lose your last resort drug.