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Morgentaler Saturation Model: PSA vs Testosterone - Estrogen Patch vs Lupron ADT
This is a plot of % reduction in PSA from a Maximum Value versus Testosterone, for two different datasets: Estrogen Patch and Lupron ADT. Both curves (red and green lines) show a linear response starting from (0,0), up to about 200-250 ng/dL. Then, the lines curve over to a lower slope (especially
This is a plot of % reduction in PSA from a Maximum Value versus Testosterone, for two different datasets: Estrogen Patch and Lupron ADT. Both curves (red and green lines) show a linear response starting from (0,0), up to about 200-250 ng/dL. Then, the lines curve over to a lower slope (especially
janebob99
in
Advanced Prostate Cancer
6 months ago
Joint pain
Hi I have a history of back pain due to bulges bit more recently joint pain in lower back. The consultant has said some degeneration found but everyone has that. We are now looking at more spinal injections and further treatment.I am in perimenopause and have been on hrt for 2 years. Everol Patches and
Hi I have a history of back pain due to bulges bit more recently joint pain in lower back. The consultant has said some degeneration found but everyone has that. We are now looking at more spinal injections and further treatment.I am in perimenopause and have been on hrt for 2 years. Everol Patches and
AMS_1
in
Menopause and Perimenopause Support
6 months ago
PSA reduction after Estrogen Patch Therapy
Here's a revised plot of PSA reduction due to castration from Estrogen Patch therapy. The previous version had the wrong time scale. That has been corrected in this version. The total time is 3 months, after which the PSA and testosterone both flatten out versus time. I've also added the reference
Here's a revised plot of PSA reduction due to castration from Estrogen Patch therapy. The previous version had the wrong time scale. That has been corrected in this version. The total time is 3 months, after which the PSA and testosterone both flatten out versus time. I've also added the reference
janebob99
in
Advanced Prostate Cancer
6 months ago
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PSA reduction by Estrogen Patch (revised)
Here's a revised plot of PSA reduction due to castration from Estrogen Patch therapy. The previous version had the wrong time scale. That has been corrected in this version. The total time is 3 months, after which the PSA and testosterone both flattened out versus time. I've also added the reference
Here's a revised plot of PSA reduction due to castration from Estrogen Patch therapy. The previous version had the wrong time scale. That has been corrected in this version. The total time is 3 months, after which the PSA and testosterone both flattened out versus time. I've also added the reference
janebob99
in
Prostate Cancer Network
6 months ago
Thyroid medication changes when starting HRT for perimenopause
I have been self medicating with liothyronine and levothyroxine for the past two years or so. Today I started the estrogen patch for perimenopause symptoms, and will also start progesterone in a couple of days. The provider that prescribed these said that some women need to increase their thyroid
I have been self medicating with liothyronine and levothyroxine for the past two years or so. Today I started the estrogen patch for perimenopause symptoms, and will also start progesterone in a couple of days. The provider that prescribed these said that some women need to increase their thyroid
TurtlesAllTheWay
in
Thyroid UK
6 months ago
PSA drop with decreasing Testosterone after Estrogen Patch Therapy
Here's a plot that I made from data taken from the PATCH estrogen patch therapy study. It plots the % reduction in PSA from baseline (100%) at time = 0 as a function of testosterone levels over a period of 4 weeks. As you know, estrogen effectively castrates men, causing a drop in testosterone over
Here's a plot that I made from data taken from the PATCH estrogen patch therapy study. It plots the % reduction in PSA from baseline (100%) at time = 0 as a function of testosterone levels over a period of 4 weeks. As you know, estrogen effectively castrates men, causing a drop in testosterone over
janebob99
in
Advanced Prostate Cancer
6 months ago
PSA drops with decreasing Testosterone
Here's a plot that I made from data taken from the PATCH estrogen patch therapy study. It plots the % reduction in PSA from baseline (100%) at time = 0 as a function of testosterone levels over a period of 4 weeks. As you know, estrogen effectively castrates men, causing a drop in testosterone over
Here's a plot that I made from data taken from the PATCH estrogen patch therapy study. It plots the % reduction in PSA from baseline (100%) at time = 0 as a function of testosterone levels over a period of 4 weeks. As you know, estrogen effectively castrates men, causing a drop in testosterone over
janebob99
in
Prostate Cancer Network
6 months ago
Gynecomastia from ADT - how much?
Gynecomastia from ADT - how much? I am considering asking my oncologist for transdermal estrogn (TDE) therapy instead of Orgovyx to combat my prostate cancer. Since gynecomastia and breast pain are pretty much the only bad side effects from TDE and less troubling to me than metabolic disturbance,
Gynecomastia from ADT - how much? I am considering asking my oncologist for transdermal estrogn (TDE) therapy instead of Orgovyx to combat my prostate cancer. Since gynecomastia and breast pain are pretty much the only bad side effects from TDE and less troubling to me than metabolic disturbance,
Lost_Sheep
in
Prostate Cancer Network
6 months ago
Next Steps
My brother was dDiagnosed in March 2023 with widespread prostate cancer metastasized to the spine, pelvic bones, ribs both left and right, and skull and lymph nodes. No progression to any organs. He had a orchiectomy, is on ABIRATERONE 500MG and has just completed six treatments of Doxetaxel .
My brother was dDiagnosed in March 2023 with widespread prostate cancer metastasized to the spine, pelvic bones, ribs both left and right, and skull and lymph nodes. No progression to any organs. He had a orchiectomy, is on ABIRATERONE 500MG and has just completed six treatments of Doxetaxel .
Sparlingo
in
Advanced Prostate Cancer
6 months ago
HRT, low white blood cell count & NDT
I have been having appointments with my GP to try and get an HRT prescription. She wanted a blood test doing first - I have been taking NDT for about 8 years (doing really well on it) and basically my GP didn't understand it, stopped calling me in for blood tests and I haven't been for years. The blood
I have been having appointments with my GP to try and get an HRT prescription. She wanted a blood test doing first - I have been taking NDT for about 8 years (doing really well on it) and basically my GP didn't understand it, stopped calling me in for blood tests and I haven't been for years. The blood
Raucous
in
Thyroid UK
3 months ago
Early Results from Transdermal Estrogen PATCH trial - 2
Here's some charts comparing Lupron ADT to transdermal estrogen (TDE) therapy for High Risk and Very High Risk men with prostate cancer. The upper chart shows the percentage of men that have been castrated to a testosterone level < 50 ng/dL after 1 month of treatment. For Lupron, only 65% of HR/VHR
Here's some charts comparing Lupron ADT to transdermal estrogen (TDE) therapy for High Risk and Very High Risk men with prostate cancer. The upper chart shows the percentage of men that have been castrated to a testosterone level < 50 ng/dL after 1 month of treatment. For Lupron, only 65% of HR/VHR
janebob99
in
Prostate Cancer Network
6 months ago
Early Results from Transdermal Estrogen PATCH trial - 2
Here's some charts comparing Lupron ADT to transdermal estrogen (TDE) patch therapy for High Risk and Very High Risk men with prostate cancer. The upper chart shows the percentage of men that have been castrated to a testosterone level < 50 ng/dL after 1 month of treatment. For Lupron, 65% of HR/
Here's some charts comparing Lupron ADT to transdermal estrogen (TDE) patch therapy for High Risk and Very High Risk men with prostate cancer. The upper chart shows the percentage of men that have been castrated to a testosterone level < 50 ng/dL after 1 month of treatment. For Lupron, 65% of HR/
janebob99
in
Advanced Prostate Cancer
6 months ago
Early Results from Transdermal Estrogen PATCH trial
Here are some Early Results from the first year of the Transdermal Estrogen PATCH trial. References are available on their website at: http://patch.mrcctu.ucl.ac.uk. The cohort was men with High or Very High Risk prostate cancer. Stage T3 (73%) and Stage T4 (14%), baseline PSA = 35 ng/mL. The upper
Here are some Early Results from the first year of the Transdermal Estrogen PATCH trial. References are available on their website at: http://patch.mrcctu.ucl.ac.uk. The cohort was men with High or Very High Risk prostate cancer. Stage T3 (73%) and Stage T4 (14%), baseline PSA = 35 ng/mL. The upper
janebob99
in
Advanced Prostate Cancer
6 months ago
Early Results of Estrogen PATCH trial - 1
Here are some Early Results from the first year of the Transdermal Estrogen PATCH trial. References are available on their website at: http://patch.mrcctu.ucl.ac.uk. The cohort was men with High or Very High Risk prostate cancer. Stage T3 (73%) and Stage T4 (14%), baseline PSA = 35 ng/mL. The upper
Here are some Early Results from the first year of the Transdermal Estrogen PATCH trial. References are available on their website at: http://patch.mrcctu.ucl.ac.uk. The cohort was men with High or Very High Risk prostate cancer. Stage T3 (73%) and Stage T4 (14%), baseline PSA = 35 ng/mL. The upper
janebob99
in
Prostate Cancer Network
6 months ago
Results
Hi everyone I posted a couple of weeks ago and was advised to have bloods done. These are my results so hoping for further advice in supplementing or adjusting doseage. I currently take 50mcg Levothyroxine and 25mcg T3 daily. I also have B12 injections every 12wks. Latest B12 injection given day after
Hi everyone I posted a couple of weeks ago and was advised to have bloods done. These are my results so hoping for further advice in supplementing or adjusting doseage. I currently take 50mcg Levothyroxine and 25mcg T3 daily. I also have B12 injections every 12wks. Latest B12 injection given day after
Pixie50
in
Thyroid UK
6 months ago
Estrogen ADT vs Lupron ADT
Here's a chart showing % of men who have a given condition, comparing Estrogen ADT versus Lupron ADT. There's big reduction in hot flashes, and improvements in libido, when taking supplemental Estrogen. Estrogen increases gynecomastia (enlarged breasts), however. Bob
Here's a chart showing % of men who have a given condition, comparing Estrogen ADT versus Lupron ADT. There's big reduction in hot flashes, and improvements in libido, when taking supplemental Estrogen. Estrogen increases gynecomastia (enlarged breasts), however. Bob
janebob99
in
Prostate Cancer Network
6 months ago
Benefits of Estrogen Patch Therapy
Here's a chart summarizing the benefits and detriments of modern Estrogen Patch Therapy, supported by numerous publications. Overall, the large numbers of benefits outweighs the few negatives.
Here's a chart summarizing the benefits and detriments of modern Estrogen Patch Therapy, supported by numerous publications. Overall, the large numbers of benefits outweighs the few negatives.
janebob99
in
Prostate Cancer Network
6 months ago
T3/T4 HRT Meds before surgery?
Hello lovely people, i hope everyone is managing to catch up on the long overdue sun ;) Sadly, my gynaecologist has found an ovarian tumour which needs to be removed and biopsied. Recovery from this will take between 6-8 weeks. I am in really good health otherwise but do take 150mg Levo and 45mg Liothyronine
Hello lovely people, i hope everyone is managing to catch up on the long overdue sun ;) Sadly, my gynaecologist has found an ovarian tumour which needs to be removed and biopsied. Recovery from this will take between 6-8 weeks. I am in really good health otherwise but do take 150mg Levo and 45mg Liothyronine
Piggyoink
in
Thyroid UK
4 months ago
No Osteoporosis with Estrogen Patch Therapy
These plots compare results from the Phase-II randomized trial (PATCH) comparing estrogen patch therapy to Lupron ADT. These plots show that Lupron ADT causes bone loss, while estrogen patch therapy has either no bone loss or increased bone mineral density (BMD) over time. Bob
These plots compare results from the Phase-II randomized trial (PATCH) comparing estrogen patch therapy to Lupron ADT. These plots show that Lupron ADT causes bone loss, while estrogen patch therapy has either no bone loss or increased bone mineral density (BMD) over time. Bob
janebob99
in
Prostate Cancer Network
6 months ago
Castration by Estrogen Patch
This plot shows a dramatic decrease in testosterone and PSA after starting estrogen patch therapy, indicating that transdermal estrogen (TDE) therapy effectively castrates men, and with fewer side effects than Lupron ADT.
This plot shows a dramatic decrease in testosterone and PSA after starting estrogen patch therapy, indicating that transdermal estrogen (TDE) therapy effectively castrates men, and with fewer side effects than Lupron ADT.
janebob99
in
Prostate Cancer Network
6 months ago
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