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interesting concepts (not applicable yet): Modulating extracellular matrix stiffness - a strategic approach to boost cancer immunotherapy
”How can targeting ECM stiffness be optimized to achieve maximal efficacy in various types of cancer immunotherapy?”….now that’s a hell of a question! https://www.nature.com/articles/s41419-024-06697-4
”How can targeting ECM stiffness be optimized to achieve maximal efficacy in various types of cancer immunotherapy?”….now that’s a hell of a question! https://www.nature.com/articles/s41419-024-06697-4
Maxone73
in
Advanced Prostate Cancer
3 months ago
Laxido longterm use
Hi all,I've been taking 1,sometimes 2 laxido sachets daily for the past 3 months and this has helped.My gastroenteritis has suggested swapping for prucalopride 1mg but this gives me all day stomach ache.My question is,is laxido safe to use daily long term?
Hi all,I've been taking 1,sometimes 2 laxido sachets daily for the past 3 months and this has helped.My gastroenteritis has suggested swapping for prucalopride 1mg but this gives me all day stomach ache.My question is,is laxido safe to use daily long term?
Ladydaff1
in
IBS Network
9 months ago
Finally got flu vax!
After 4+ months of waiting told 'on the list' many times, nurse from gp surgery came. Says don't know what district nurses are doing lately. 🤷♀️ Also gave me pneumonia vax- never had or been offered before🤔 No Covid as run out. Can I sue if I contract Covid or is it all forgotten about now? Yet I
After 4+ months of waiting told 'on the list' many times, nurse from gp surgery came. Says don't know what district nurses are doing lately. 🤷♀️ Also gave me pneumonia vax- never had or been offered before🤔 No Covid as run out. Can I sue if I contract Covid or is it all forgotten about now? Yet I
fraid
in
Asthma Community Forum
6 months ago
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Anxiety or hormones?
I've been feeling light headed and off balance since being diagnosed hypothyroid years ago, could be meds side effects or the gland itself. I'm also post menopausal so low oestrogen. Allergies bung up the eustachian tunes cause imbalance. All of these can cause disequilibrium leading to anxiety. I had
I've been feeling light headed and off balance since being diagnosed hypothyroid years ago, could be meds side effects or the gland itself. I'm also post menopausal so low oestrogen. Allergies bung up the eustachian tunes cause imbalance. All of these can cause disequilibrium leading to anxiety. I had
celticlady
in
Anxiety Support
8 months ago
tp53 mutation
Hi All, my dad has been diagnosed with CLL and has just had it confirmed that he has the TP53 mutation/deletion. He is stable at the moment and is currently on watch & wait. His consultant has said if and when he starts treatment it will be for life or until it isn’t effective. I’ve read lots that say
Hi All, my dad has been diagnosed with CLL and has just had it confirmed that he has the TP53 mutation/deletion. He is stable at the moment and is currently on watch & wait. His consultant has said if and when he starts treatment it will be for life or until it isn’t effective. I’ve read lots that say
Fortheloveoffarming
in
CLL Support
3 months ago
liquid biopsy lung cancer
Hello everyone, Does anyone have experience of a liquid biopsy either via the NHS or privately? We got a second opinion, discussed the case with a professor who recommended a guardant 360 liquid biopsy due to the unusual spread into the other lung & appearance during biopsy which is apparently usually
Hello everyone, Does anyone have experience of a liquid biopsy either via the NHS or privately? We got a second opinion, discussed the case with a professor who recommended a guardant 360 liquid biopsy due to the unusual spread into the other lung & appearance during biopsy which is apparently usually
Clark74517796
in
The Roy Castle Lung Cancer Foundation
3 months ago
filgotinib and shingles,
hi everyone Just getting over last 2 weeks of awful shingles ,my god painful or what!! As I am on filgotinib and it lists side effect can be reactivation of shingles virus,I can only assume it is that.Has anyone else had shingles while on any of the JAK meds? Pharmacist prescribed antivirals within
hi everyone Just getting over last 2 weeks of awful shingles ,my god painful or what!! As I am on filgotinib and it lists side effect can be reactivation of shingles virus,I can only assume it is that.Has anyone else had shingles while on any of the JAK meds? Pharmacist prescribed antivirals within
Doodlereggie
in
NRAS
3 months ago
Different mutation?
I was just checking via my NHS app what had been sent to my GP, when I noticed on a letter from Guys this - it listed my mutations - CGN - normal karotype, NGS - CALR, L2AF1, ASXL2. (High risk markers) Previously I thought I was ASXL1, it could be a typo I suppose but does anyone know the difference
I was just checking via my NHS app what had been sent to my GP, when I noticed on a letter from Guys this - it listed my mutations - CGN - normal karotype, NGS - CALR, L2AF1, ASXL2. (High risk markers) Previously I thought I was ASXL1, it could be a typo I suppose but does anyone know the difference
lizzziep
in
MPN Voice
3 months ago
EXERCISE is our best med.
I wrote this in response to a post that seems to have disappeared This is one of the most important post topics on this board. [i] In another large, phase 3 clinical trial funded by Movember, Chan and epidemiologists Stacey Kenfield and Lorelei Mucci, with principal investigators Rob Newton and
I wrote this in response to a post that seems to have disappeared This is one of the most important post topics on this board. [i] In another large, phase 3 clinical trial funded by Movember, Chan and epidemiologists Stacey Kenfield and Lorelei Mucci, with principal investigators Rob Newton and
Scout4answers
in
Advanced Prostate Cancer
3 months ago
Review of medication at GP.
Just seen on my GP notes on line my medication review. I have not seen this gp or any other for this review.i am on 4 sheets of prescription pad.is this normal? I would have thought with 3 previous heart attacks ,14 stents, bronchitis, constant pain in legs and feet, diabetes I would have been consulted
Just seen on my GP notes on line my medication review. I have not seen this gp or any other for this review.i am on 4 sheets of prescription pad.is this normal? I would have thought with 3 previous heart attacks ,14 stents, bronchitis, constant pain in legs and feet, diabetes I would have been consulted
jhorsf
in
Lung Conditions Community Forum
3 months ago
Recently diagnosed and trying to work out what to do! All advice gratefully received.
I was diagnosed this week. Still in shock a bit as I am a fit and very active 58 with no real symptoms. I have a psa of 7.7. Gleason Score 3+4 = 7 one in 10 cores with a 2.5mm tumour length whoich is 20% of the core involved. 30% of cores showed cribreform pattern 4 glands. Area of concern on MRIs
I was diagnosed this week. Still in shock a bit as I am a fit and very active 58 with no real symptoms. I have a psa of 7.7. Gleason Score 3+4 = 7 one in 10 cores with a 2.5mm tumour length whoich is 20% of the core involved. 30% of cores showed cribreform pattern 4 glands. Area of concern on MRIs
welshsky
in
Prostate Cancer Network
3 months ago
autoimmunity
I went to Laurie Mischley’s alumni camp in August. One of the Labs that I decided to get done called Nuro zoomer I believe, had an interesting result. Turns out I have auto immunity to my glycine receptors. There’s not a whole lot about this online, but apparently in some cases it can cause parkinsonism
I went to Laurie Mischley’s alumni camp in August. One of the Labs that I decided to get done called Nuro zoomer I believe, had an interesting result. Turns out I have auto immunity to my glycine receptors. There’s not a whole lot about this online, but apparently in some cases it can cause parkinsonism
rebtar
in
Cure Parkinson's
9 months ago
Always hit pca hard especially in the beginning and follow your instincts, You are Your Own Best Advocate.
Update Husband fighting with Stage 4 pca 06/2022 3 lytic lesions Seen same Medical Oncologist since 07/2022 Received a call from PA after only in this fight for 1.8 years and my husband has liver metastaties We don’t know how many or how big, as MO has not released pet scan of course we are devastated
Update Husband fighting with Stage 4 pca 06/2022 3 lytic lesions Seen same Medical Oncologist since 07/2022 Received a call from PA after only in this fight for 1.8 years and my husband has liver metastaties We don’t know how many or how big, as MO has not released pet scan of course we are devastated
Shorehousejam
in
Advanced Prostate Cancer
3 months ago
Today was a good day
My husband had his PSMA scan today and it was negative for mets!! I am so relieved! He also had his PSA tested today and no change since December. I feel like I can breathe for a moment. We also met with the radiation oncologist this morning to discuss brachytherapy boost and it was a very positive meeting
My husband had his PSMA scan today and it was negative for mets!! I am so relieved! He also had his PSA tested today and no change since December. I feel like I can breathe for a moment. We also met with the radiation oncologist this morning to discuss brachytherapy boost and it was a very positive meeting
EvFC
in
Advanced Prostate Cancer
3 months ago
better delivery for better results: nanolipid particles work well in vivo
”Mitchell and postdoctoral fellow Lulu Xue were able to achieve therapeutic mRNA delivery into the lungs, helping to eradicate metastatic lung cancer in preclinical mouse model studies. ” https://www.thedp.com/article/2024/04/penn-lipid-nanoparticles-michael-mitchell-research
”Mitchell and postdoctoral fellow Lulu Xue were able to achieve therapeutic mRNA delivery into the lungs, helping to eradicate metastatic lung cancer in preclinical mouse model studies. ” https://www.thedp.com/article/2024/04/penn-lipid-nanoparticles-michael-mitchell-research
Maxone73
in
Advanced Prostate Cancer
3 months ago
Surgery or radiotheraphy?
Hi, I writing this post on behalf if my husband who is 41 and was diagnosed with an acoustic neuroma in January. He has been referred to The Queen Elizabeth under Richard Irving and we had a lengthy discussion last week about options as the tumour is at a size where it needs treatment. My husband is
Hi, I writing this post on behalf if my husband who is 41 and was diagnosed with an acoustic neuroma in January. He has been referred to The Queen Elizabeth under Richard Irving and we had a lengthy discussion last week about options as the tumour is at a size where it needs treatment. My husband is
Zhad
in
Acoustic Neuroma Support
3 months ago
Does Immunotherapy cause Vasculitis?
Hi, my Mum had vasculitis in 2013 following a bad infection, she continues to take 5mg prednisone to this day.Sadly she has been diagnosed with a stage 2 tumor of the cecum which because of her age and frailty at 81 years old is suggested to be inoperable. Genetic testing reveals its a type of cancer
Hi, my Mum had vasculitis in 2013 following a bad infection, she continues to take 5mg prednisone to this day.Sadly she has been diagnosed with a stage 2 tumor of the cecum which because of her age and frailty at 81 years old is suggested to be inoperable. Genetic testing reveals its a type of cancer
luggsey
in
Vasculitis UK
3 months ago
What to expect with mets and no treatment
4 months of study everywhere online- future life reading all the suffering here on this forum with side effects, impotence, recurrence, hormone therapy, other side effects, etc. My heart goes out to all of you, and my hats off to you warriors, who have chosen to fight this battle with conventional
4 months of study everywhere online- future life reading all the suffering here on this forum with side effects, impotence, recurrence, hormone therapy, other side effects, etc. My heart goes out to all of you, and my hats off to you warriors, who have chosen to fight this battle with conventional
Nwdx
in
Advanced Prostate Cancer
3 months ago
Weightlifting (machines) during SBRT?
(duplicate post) I am starting my five SBRT sessions tomorrow, April 29, 2024. I was not supposed to lift over ten pounds between my MRI/CT scan to locate my fiducials and my SBRT. I miss my workouts. Can I return to the gym with workouts on machines that isolate my muscle groups and avoid stress
(duplicate post) I am starting my five SBRT sessions tomorrow, April 29, 2024. I was not supposed to lift over ten pounds between my MRI/CT scan to locate my fiducials and my SBRT. I miss my workouts. Can I return to the gym with workouts on machines that isolate my muscle groups and avoid stress
Worked_the_World
in
Advanced Prostate Cancer
3 months ago
first recurrence
hi peeps , I started new rounds of chemo for floating cluster cells , detected after they drained 2.5 L of fluid from my belly. CA 125 820 I’m on Carboplatin / gemcitabine Did anyone had the same?
hi peeps , I started new rounds of chemo for floating cluster cells , detected after they drained 2.5 L of fluid from my belly. CA 125 820 I’m on Carboplatin / gemcitabine Did anyone had the same?
Vegana
in
My Ovacome
3 months ago
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