I started reading about this and found it fascinating. I am attaching one case where they found treatment for the condition in one patient but it seemed hopeful. Please excuse me if this has been sent to you already. Cheers
“Immunotherapies (such as corticosteroids, IVIG, PLEX, cyclophosphamide) are used, sometimes in combination, to treat GlyR antibody encephalitis. If a tumor is detected, treatment of the neurological disorder may depend on successful treatment of the tumor.
Additional treatments are used alongside immunotherapy to control the clinical symptoms. For example motor hyperexcitability and pain may be treated with clonazepam, diazepam, baclofen or gabapentin, and anticonvulsants such as leviteracetam may be used in patients who have seizures.”
Have you tried clonazapam or gabapentin? These can be prescribed for PD but I guess they just dull down symptoms rather than curing the underlying problem.
Have had autoimmune reaction, allergy & intolerance, to sugar, sucrose, glucose, and fructose, and really a hypersensitivity to aspartame (when it hit the markets), all my life, and have had to take antihistamines chronically since about age five for "atopic skin," and chronic itching ("pruritis"), and sometimes significant itching in deeper tissues such as ear canals, lungs and trachea airways, etc., think of the feeling that your windpipe and where you feel your coughs are aching to get you to run a toothbrush over them kind of that kind of itching and that kind of location) back when it was by prescription only...in other words, 63 years. Very strong itching in all cases. Have never been able to convince doctors (except dematologists who these days seem not at all as surprised at the idea) that it's an allergy or autoimmune. The deep airway itching is relieved by an even stronger version of antihistamine, or at least a higher dose, of dextromathorphan. Some of these articles are therefore really interesting, obviously recent.
I've never had a known allergy to anything, until recently I discovered that I'm allergic to Erythritol. That, buying a monk fruit sweetener and not reading the label, although that might not have made a difference, since I didn't know I was allergic to erythritol. I had a severe allergic reaction, hives all over my body, my entire body was bright red, trembling, weakness, and if it hadn't been the beginning of the pandemic, I probably would have gone to the ER. An advice nurse talked me through double dosing Benadryl and sitting in a cold bath for a while. Took several hours for the itching to subside.
Wow. Yes benadryl is the one. These days Zyrtec is the one that dispenses with the dry mouth and dry nasal areas, and the dry mouth is a tooth decay issue for sure so it's nice to have something that does not have the anticholinergic side effects that Benadryl and clortrimeton had... But of course it's very expensive. Actually Zyrtec is the next generation derivative of Benadryl.
And of course we and anybody who uses it frequently will feel that they're addicted, and I feel that way too. Certainly I fit every definition through the evolving series of the DSM-III, IV, and V, and of course the international medical diagnostic classification system called ICD, international classification of disorders, which physicians around the world use as thier formal diagnostic classification compendium.
But you know what, it's better then itching everyday all day and the intensity of it, even if you try to go down on the sugar, childhood formations or whatever keep you in that range of allergic and addicted, so Zyrtec is as good as any of them, better on your teeth, even though it's more expensive. After all, Zyrtec is the active component of Benadryl anyway, but stripped off the anticholinergic dry mouth effects, which means you don't have dry mouth and you don't have throat problems and throat pain.
So if you're going to be addicted to something, and of course we are all addicted to food and so many other things BECAUSE our brain is structured to be so, well this is good as any if you can afford the Zyrtec.
And I really think it is passe to worry about addictions, because our brain is actually evolved to become addicted to things that help us survive, yes just when we have negative consequences of the addiction that we complain about it, but it's not addiction per se that is the evil, but rather, addiction per se helped us survive and still does.
Thus it is every bit realistic and appropriate to say that we are addicted to food, and I maintain that is a realistic literal example to illustrate my point and also what science no2 supports. Just think about it for a while. We started learning this in the early 1980s and now at least those of us who are around to appreciate where things in science have gone and where biochemistry has gone, we really understand that that was an appropriate model, I e, ADDICTION IN SERVICE OF SURVIVAL and therefore fully consistent with evolutionary principles.
Thus, addiction per se is not the problem, first survival benefit we are actually designed to be addictive beings, it's not the substance, it Is us. It's when addiction gets out of control or has negative consequences that is the problem. And I'm here to tell you that I am just not phrasing it in a nice colloquial manner, I'm talking about real established experimental science supporting these ideas, now I guess since about 1979 or so, 40 or 45 years of legitimate experimental scientific evidence to establish the idea. How do I know this, well it's because that's exactly what I was getting my best graduate training right then in experimental psychology, so I was lucky enough to have realized what was happening at the appropriate moment, and now, about 50 years of professional and clinical science evolution since then to put it in perspective.
It's not so much of the substances are addictive, it's that WE, in service of some survival principle that fits evolution, are addictive-dependent beings. In other words, it's us, not the chemical.
Beautiful and excellent example my friend. And entirely legitimate and valid in terms of science and in terms of biochemistry. There is still so much we are only just beginning to appreciate.
It's also found in mushrooms and fermented foods like beer, cheese, sake, soy sauce and wine. In addition to whole foods, erythritol is commercially produced for use in baked goods, beverages, candies, chewing gums, chocolates and tabletop sweetener packets.1 Mar 2023”
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It’s a lonely road with PD. 
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