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Time restricted eating and impact of autophagy on prostate cancer
Once the tumors progress to late stage and are established and subjected to the environmental stresses, autophagy, as a dynamic degradation and recycling system, contributes to the survival and growth of the established tumors and promotes aggressiveness of the cancers by facilitating
metastasis
. "
Once the tumors progress to late stage and are established and subjected to the environmental stresses, autophagy, as a dynamic degradation and recycling system, contributes to the survival and growth of the established tumors and promotes aggressiveness of the cancers by facilitating
metastasis
. "
traveller64
in
Advanced Prostate Cancer
1 year ago
Vitamin D supplements and elevated blood work
here is my story and my question. Everything has been going well for me for about a year. Blood work stable, tumor marker test levels decreasing and stable scans. However, recently I was diagnosed with very low levels of vitamin D and began supplementation with 50,000 IU once a week. Since I misunderstood
here is my story and my question. Everything has been going well for me for about a year. Blood work stable, tumor marker test levels decreasing and stable scans. However, recently I was diagnosed with very low levels of vitamin D and began supplementation with 50,000 IU once a week. Since I misunderstood
CatLady2022
in
SHARE Metastatic Breast Cancer
1 year ago
Night Pain , Left -Flank
I will ask her about
metastasis
when I see her . Thank You
I will ask her about
metastasis
when I see her . Thank You
reconjj
in
Fight Prostate Cancer
1 year ago
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Halfway through chemo, new scans, seeking advice
The the largest osseous
metastasis
continues to be in the L3 vertebral body filling almost the entire vertebral body (SUV max 25.7).
The the largest osseous
metastasis
continues to be in the L3 vertebral body filling almost the entire vertebral body (SUV max 25.7).
Skifanatic
in
Advanced Prostate Cancer
1 year ago
Hey Y'all
Just stumbled across this site. I'm a MBC Thriver!! In July 2017 it was confirmed that I in fact had HR+ HER2- BC after years of mammograms and ultrasounds. I always knew it was cancer that was causing my issues. At 39 most OB/GYN play it off as hormone changes. What was the final straw was I lost my
Just stumbled across this site. I'm a MBC Thriver!! In July 2017 it was confirmed that I in fact had HR+ HER2- BC after years of mammograms and ultrasounds. I always knew it was cancer that was causing my issues. At 39 most OB/GYN play it off as hormone changes. What was the final straw was I lost my
tamtam425
in
SHARE Metastatic Breast Cancer
1 year ago
metastatic lobular carcinoma to peritoneum
just diagnosed with metastatic lobular carcinoma to the peritoneal. Will start Letrozole/Kisquali soon. Anyone with success on this drug? It’s relatively new.
just diagnosed with metastatic lobular carcinoma to the peritoneal. Will start Letrozole/Kisquali soon. Anyone with success on this drug? It’s relatively new.
CLC-52
in
SHARE Metastatic Breast Cancer
1 year ago
Breast cancer
Hi folks, I was diagnosed with breast cancer in January of this year. My first surgery removed a lump and 2 lymph nodes, the second was to take more shavings. As a result of that it found more cells which led to having a mastectomy . At my follow up appt yesterday they've decided to put me on Letrozole
Hi folks, I was diagnosed with breast cancer in January of this year. My first surgery removed a lump and 2 lymph nodes, the second was to take more shavings. As a result of that it found more cells which led to having a mastectomy . At my follow up appt yesterday they've decided to put me on Letrozole
Pixiemax19
in
SHARE Metastatic Breast Cancer
1 year ago
have anyone taken part in the serena 6 trial and can tell me how they got on
I have stage 4 metastatic breast cancer (liver and bones) iv done 6 cycles of Ec chemotherapy and I’m due to start letrazole and abmeciclib on April 21st Does anyone here have this and how did you find it My bones have all healed and iv been told I’m stable re my cancer After 6 months I have been
I have stage 4 metastatic breast cancer (liver and bones) iv done 6 cycles of Ec chemotherapy and I’m due to start letrazole and abmeciclib on April 21st Does anyone here have this and how did you find it My bones have all healed and iv been told I’m stable re my cancer After 6 months I have been
Sharonpat
in
SHARE Metastatic Breast Cancer
1 year ago
What next option available if CDK4/6 get failed
Hi all and Dr. Sumeet Shah one of my relative diagnosed with oligometastatic left breast cancer in 2015 treated with chemo (4 Cycle 5FEC and 1 Cycle of Docetaxel) than surgery (lumpectomy) again 2 cycle of 5FEC chemo 2016 march NED put on tamoxifen 20 mg regular check up and in 2021 it relapsed in
Hi all and Dr. Sumeet Shah one of my relative diagnosed with oligometastatic left breast cancer in 2015 treated with chemo (4 Cycle 5FEC and 1 Cycle of Docetaxel) than surgery (lumpectomy) again 2 cycle of 5FEC chemo 2016 march NED put on tamoxifen 20 mg regular check up and in 2021 it relapsed in
Deepak1965
in
Breast Cancer India
1 year ago
Need an Advise and Info on Very Experienced Doctors and Centers to do Proton Treatment of the Prostate in Oligometastatic Setting
There was three confirmed pelvic lympnodes and one right femur
metastasis
. Lymphnodes were cleared by Lu-177 and Femur by SBRT.
There was three confirmed pelvic lympnodes and one right femur
metastasis
. Lymphnodes were cleared by Lu-177 and Femur by SBRT.
CurrentSEO
in
Advanced Prostate Cancer
1 year ago
Stage 4 Prostate Cancer treated with Xtandi- 3 pills & Zolodex; 1.5 yrs diagnosed, now left side pain under ribs
Some
Metastasis
to the ribs- right and left side. Thoughts are that pain could be muscular. Ultrasound is not definitive but the oncologist is reluctant to do a colonoscopy. Has anyone experienced any pain similar? I am periodically taking Advil to relieve the discomfort.
Some
Metastasis
to the ribs- right and left side. Thoughts are that pain could be muscular. Ultrasound is not definitive but the oncologist is reluctant to do a colonoscopy. Has anyone experienced any pain similar? I am periodically taking Advil to relieve the discomfort.
Hidden
in
Advanced Prostate Cancer
1 year ago
Addition of Metastasis-Directed Therapy to Intermittent Hormone Therapy for Oligometastatic PC. The EXTEND Phase 2 Randomized Clinical Trial
MDT and intermittent ADT offer a progression free survival advantage when compared with intermittent ADT alone. "MDT facilitated a longer time with eugonadal testosterone as part of an intermittent hormone therapy strategy." "Time to new lesion failure was longer for patients randomized to combined
MDT and intermittent ADT offer a progression free survival advantage when compared with intermittent ADT alone. "MDT facilitated a longer time with eugonadal testosterone as part of an intermittent hormone therapy strategy." "Time to new lesion failure was longer for patients randomized to combined
tango65
in
Advanced Prostate Cancer
1 year ago
Taxol For MBC
Good morning. After taking Ibrance w/ Fulvestrant for 8 mos., it stopped working 2 mos. ago. The next plan is Piqray w/ Fulvestrant, but the side effect were too much - especially to my one remaining eye (the mucous membrane). Next plan, which I should begin this Wed. if ins. approves, is Taxol infusions
Good morning. After taking Ibrance w/ Fulvestrant for 8 mos., it stopped working 2 mos. ago. The next plan is Piqray w/ Fulvestrant, but the side effect were too much - especially to my one remaining eye (the mucous membrane). Next plan, which I should begin this Wed. if ins. approves, is Taxol infusions
macspow
in
SHARE Metastatic Breast Cancer
1 year ago
is it too much to hope for shrinkage?
I’m stage 4 in breast, liver, multiple bones and lung. Been attempting completely natural for over 2 years. Last scan showed some improvement but the breast tumor is getting harder and larger. So now going all in with what my amazing oncologist is suggesting. Started on Ibrance and Anastrozole this last
I’m stage 4 in breast, liver, multiple bones and lung. Been attempting completely natural for over 2 years. Last scan showed some improvement but the breast tumor is getting harder and larger. So now going all in with what my amazing oncologist is suggesting. Started on Ibrance and Anastrozole this last
HbbM
in
SHARE Metastatic Breast Cancer
1 year ago
Faslodex + Ibrance - new mets
Hi everyone! My mother is on ibrance and faslodex for 15 cycles. she had pelvic metastases that are still under control, but there are new ones on her spine. she will continue to receive the same therapy. Does anyone have a similar experience? is it possible to keep the disease under control even
Hi everyone! My mother is on ibrance and faslodex for 15 cycles. she had pelvic metastases that are still under control, but there are new ones on her spine. she will continue to receive the same therapy. Does anyone have a similar experience? is it possible to keep the disease under control even
Goga156
in
SHARE Metastatic Breast Cancer
1 year ago
CCR6 & CCL20 are the key drivers in prostate tumor microenvironment.
It seems that CCL20 promotes cancer
metastasis
. In addition, it increases cancer stem cells and causes T cell exhaustion. These actions will suppress an immune response.
It seems that CCL20 promotes cancer
metastasis
. In addition, it increases cancer stem cells and causes T cell exhaustion. These actions will suppress an immune response.
KocoPr
in
Fight Prostate Cancer
4 months ago
Monoamine oxidase A (MAOA): A promising target for prostate cancer therapy
Cancer-cell-derived MAOA also enables cancer-stromal cell interaction involving bone stromal cells and nerve cells by secretion of Hedgehog and class 3 semaphorin molecules respectively to modulate the tumor microenvironment in favor of invasion and
metastasis
.
Cancer-cell-derived MAOA also enables cancer-stromal cell interaction involving bone stromal cells and nerve cells by secretion of Hedgehog and class 3 semaphorin molecules respectively to modulate the tumor microenvironment in favor of invasion and
metastasis
.
pjoshea13
in
Fight Prostate Cancer
1 year ago
Holiday inspiration!
Hi lovely ladies, After reading about Beth’s amazing travels in New Zealand, I hope to encourage you to follow your dreams with travel when you can. I am from the UK, and was crushed when I had to cancel my planned silver wedding anniversary trip to New England twice, the first time because of the pandemic
Hi lovely ladies, After reading about Beth’s amazing travels in New Zealand, I hope to encourage you to follow your dreams with travel when you can. I am from the UK, and was crushed when I had to cancel my planned silver wedding anniversary trip to New England twice, the first time because of the pandemic
LibraryGeek
in
SHARE Metastatic Breast Cancer
1 year ago
Starting Xeloda soon
I am a rare case for Johns Hopkins. Dx de novo ER/Pr +, Her2 - almost 8 years ago. Two very tiny liver mets only. Did extremely well and achieved NED status on Ibrance and AI for 6.5 years when we noticed the primary site of cancer in the breast was growing. Switched to Faslodex and Fulvestrant.
I am a rare case for Johns Hopkins. Dx de novo ER/Pr +, Her2 - almost 8 years ago. Two very tiny liver mets only. Did extremely well and achieved NED status on Ibrance and AI for 6.5 years when we noticed the primary site of cancer in the breast was growing. Switched to Faslodex and Fulvestrant.
MeeyaNicole
in
SHARE Metastatic Breast Cancer
1 year ago
Pet PSMA result
No new
metastasis
or locally recurrent disease. 2. Focal areas of low mild PSMA activity involving the T3 vertebral body and right 5th and left 6th ribs which Re favored to be benign fiven the low level activity. MiPSMA Expression score:1 My PSA has decreased from 1.6 to 0.39.
No new
metastasis
or locally recurrent disease. 2. Focal areas of low mild PSMA activity involving the T3 vertebral body and right 5th and left 6th ribs which Re favored to be benign fiven the low level activity. MiPSMA Expression score:1 My PSA has decreased from 1.6 to 0.39.
venecia1983
in
Advanced Prostate Cancer
1 year ago
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