Experiences with

MabThera

I have tried various combination of drugs and was finally put on mabthera. My new rheumatologist says he can't see swellings and sent me to have scans on my hands and feet.

I have just started humira after reacting badly to mabthera. I have also previously been on methotrexate, azaoress, nivaquin abd high dose steroids to name a few. I have read some scary posts about humira causing lymphoma and leukemia, abd am quite worried.

In addition, they may experience: • Treatment-related immunodeficiency (such as that resulting from anti-CD20 monoclonal antibody treatment such as Rituximab (Mabthera/Rituxan), Obinutuzumab (Gazyva) or ofatumumab (Arzerra) In a recent study, ‘individual risk factors associated with a poor prognosis

I’ve been feeling a bit more blurgh than usual after these infusions and just put it down to the Christmas rush prep etc, I’ve just pulled out my alert card and it says I was treated with Truxima (Rituximab) when I used to receive Mabthera (Rituximab).

She's not been able to have her second infusion on Rituximab / Mabthera, due to a urinary infection. Its now been 3 weeks since her first infusion.

I have been having infusions of Rituxan/Mabthera on and off, for about ten years. Onset of MS 1981. Has anyone had a similar experience with this drug?

My specialist has asked me to try going back on Methotrexate tablets which, together with the Mabthera infusions are meant to help get the chronic and out of control RA a little better. Last time I tried Methotrexate I was really sick (with both tablets and injections).

I've just had the 2nd infusion (3 course) on Tuesday this week, but since then I seem to have gone down hill v quickly with possible side effects. I have had terrible stomach problems (stomach pain, gas, diah) and now feel totally dehyrdrated and needless to say 'fatigue' doesn't seem to be strong enough

Mabthera/Rituximab, Gazyva/Obinutuzumab) and the increased development of personalised medicine. Neil Photo: Correa wildflower

Please can you tell me if Rituximab (Mabthera) will cause hair fall??? Who tried or have experience with this drug! I read the possible side effects and I was completely scared! I don't know what to do!!!

So please, have a safe and enjoyable Christmas by being careful what you eat, taking particular care to avoid foods that have not been adequately refrigerated and for those under treatment or recently treated with anti-CD20 antibodies like Rituximab/Mabthera or Gazyva/Obinutuzumab, foods not recommended

•Stephen Mulligan presented on results of safety & efficacy of the CLL 5 OFOCIR trial which compared oral FC in varying doses & schedules combined with IV Mabthera in elderly previously untreated patients..... a personal highlight for me - as it was the first haematology trial I ever worked on!

Cimzia and mabthera did nothing at all. Now I'm having actemra infusion every month. Nothing changed after 2 infusions. Any one felt better using actemra? How long do I have to wait to feel better?

REACH (NCT0090051) was an open-label randomized (1:1) phase III trial in relapsed CLL comparing FC with FCR, (that is comparing traditional chemotherapy using Fludarabine+Cyclophosphamide, compared to immunochemotherapy in which the monoclonal CD20 antibody Rituximab/Mabthera is added to the Fludarabine

My rheumatologist has treated me with an immunosuppressant infusion called mabthera (drastic substance called rituximab) this July and my skin has softened somewhat. On the other hand, I have trouble swallowing and keeping good down. The worst is a choking feeling.

This related article in New Scientist explains that it is [u]Rituximab/Mabthera[/u], the monoclonal antibody that is used with many CLL treatments to provide deeper and longer remissions and for some of us, the possibility of a cure with FCR: Antibody wipeout relieves symptoms of chronic fatigue syndrome

This Hematology times article examines research into how CD 20 Monoclonal Antibodies such as Mabthera®/Rituximab/Rituxan (the R in FCR) and obinutuzumab/GAZYVA®, trigger macrophages to engulf and destroy our B-CLL cells when we are treated with immunochemotherapy.

before embrel and that did not work at all and the same can be said of cimzia, I have been doing a bit of research and the 2 that have not worked are in a different anti-tnf group adalimumab-humira certolizumab-cimzia in the same group as these 2 are golimumab-simponi infliximab-remicade rituximab-mabthera

I had my first two infusions of rituximab in October and November, and by December was feeling so much better and for once Christmas was a joy instead of wiping me out with fatigue. I hadn't felt so well for years and would still be ok if I hadn't caught the lurgy after Christmas. It's still hanging

Many are familiar to us; Imbruvica of course and Revlimid (Lenalidomide), Rituxan (Rituximab/Mabthera) and perhaps Gleevec (Imatinib), the drug that did for CML what we are still looking for with CLL.