Hello. My specialist has asked me to try going back on Methotrexate tablets which, together with the Mabthera infusions are meant to help get the chronic and out of control RA a little better. Last time I tried Methotrexate I was really sick (with both tablets and injections). It caused horrible nausea to the point that I couldn't leave the house. Im a little scared taking this drug again but agreed to do so as the situation with my inflammation and joint pain is so bad. I am to take three tablets once a week and started the first dose today. I am wondering if anyone on here has any handy hints to help with the sickness. I would greatly appreciate any help you can offer.