A couple of days ago Sue (wroxham) mentioned yuppie flu in response to Ducksoup's post 'Fatigue, frustration and Community':https://healthunlocked.com/cllsupport/posts/131979723/fatigue-frustration-and-community
So I was very interested to read two New Scientist articles from early this month, commencing with:
Chronic fatigue breakthrough offers hope for millions
So what is the breakthrough? This related article in New Scientist explains that it is Rituximab/Mabthera, the monoclonal antibody that is used with many CLL treatments to provide deeper and longer remissions and for some of us, the possibility of a cure with FCR:
Antibody wipeout relieves symptoms of chronic fatigue syndrome
"The latest study implicates the immune system (in Chronic Fatigue Syndrome), at least in some cases. Rituximab wipes out most of the body's B-cells, which are the white blood cells that make antibodies.
Øystein Fluge and Olav Mella of the Haukeland University Hospital in Bergen noticed its effect on CFS symptoms in 2004, when they used the drug to treat lymphoma in a person who happened to also have CFS. Several months later, their CFS symptoms had disappeared. A small, one-year trial in people with CFS in 2011 found that two-thirds of those who received rituximab experienced relief, compared with none of the control group.
The most recent study, involving 29 people with CFS, shows that repeated rituximab infusions can keep symptoms at bay for years (PLoS One, DOI: 10.1371/journal.pone.0129898). "Eleven of the 18 responders were still in remission three years after beginning the treatment, and some have now had no symptoms for five years," says Fluge. "Suddenly, their limbs started to work again and their hands were no longer cold or sweaty."
(Both New Scientist articles can be read if your register (free); you don't need a New Scientist subscription.)
Is anyone that has struggled with the sometimes crippling fatigue that comes with CLL really surprised?