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Olaparib hasn’t worked for me . Anyone had this happen and had success with another PARP?
Hi everyone, I’m back of Chemo for 3rd line, this time with Carbo and Caelyx. This is just a year after 1st recurrence, Chemo reduced cancer to nearly NED, 7 months of Olaparib and then CT scan showed new tumour on spleen. CA125 36. Oncologist mentioned later trying another PARP possibly Rucaparib
Hi everyone, I’m back of Chemo for 3rd line, this time with Carbo and Caelyx. This is just a year after 1st recurrence, Chemo reduced cancer to nearly NED, 7 months of Olaparib and then CT scan showed new tumour on spleen. CA125 36. Oncologist mentioned later trying another PARP possibly Rucaparib
Towergirl
in
My Ovacome
7 months ago
ATM gene mutation
I just received results from genetic testing that I have a ATM gene mutation. I am currently not on any meds and my last PSMA pet scan was negation. I am scheduled for a follow up PSA test mid march based on rising PSA after 5 years undetectable. Based on the ATM finding will this change any future therapy
I just received results from genetic testing that I have a ATM gene mutation. I am currently not on any meds and my last PSMA pet scan was negation. I am scheduled for a follow up PSA test mid march based on rising PSA after 5 years undetectable. Based on the ATM finding will this change any future therapy
Rfs1975
in
Advanced Prostate Cancer
7 months ago
Not about PCa but interesting: GLP-1 Receptor Agonists help with colorectal cancer
"A research letter recently published in JAMA Oncology has provided some promising insights into the potential of Glucagon-like peptide 1 receptor agonists (GLP-1 RAs) in lowering the risk of colorectal cancer (CRC) among patients with type 2 diabetes. The study involved a national retrospective analysis
"A research letter recently published in JAMA Oncology has provided some promising insights into the potential of Glucagon-like peptide 1 receptor agonists (GLP-1 RAs) in lowering the risk of colorectal cancer (CRC) among patients with type 2 diabetes. The study involved a national retrospective analysis
Maxone73
in
Fight Prostate Cancer
7 months ago
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How to Know When Disimpaction is Complete
I'm doing disimpaction for my 7 year old. She's been constipated and on laxatives for years. I did 2 weeks of the sachet schedule and then 6 days adding bisacodyl tablet at night & suppository morning. She's had very watery stool (sometimes clear or light brown with just tiny bits spraying out, sometimes
I'm doing disimpaction for my 7 year old. She's been constipated and on laxatives for years. I did 2 weeks of the sachet schedule and then 6 days adding bisacodyl tablet at night & suppository morning. She's had very watery stool (sometimes clear or light brown with just tiny bits spraying out, sometimes
Maplelover
in
ERIC
5 months ago
worried
Hi there, I’ve been struggling with constipation for a few years but recently every 2-3 weeks when I actually need to go I get shocking pains that feel like I’m in labour but am constipated for ages and then awful runs that have blood. I have a niggly right hand pain, feel full very quick and not eating
Hi there, I’ve been struggling with constipation for a few years but recently every 2-3 weeks when I actually need to go I get shocking pains that feel like I’m in labour but am constipated for ages and then awful runs that have blood. I have a niggly right hand pain, feel full very quick and not eating
Sarah1611
in
Crohn's and Colitis Support
5 months ago
ibs an a wee rant
Hi, it’s been a while since I last posted re ibs. It’s been 20 odd years that I’ve gradually suffered (more) with what I thought and was told was ibs. I’ve tried various diets/ over counter meds/ prescribed meds, basically spent a small fortune trying out various things. Over the last few years my diarrhoea
Hi, it’s been a while since I last posted re ibs. It’s been 20 odd years that I’ve gradually suffered (more) with what I thought and was told was ibs. I’ve tried various diets/ over counter meds/ prescribed meds, basically spent a small fortune trying out various things. Over the last few years my diarrhoea
BaneOfRagnar
in
IBS Network
5 months ago
Which Treatment for These Biopsy Results?
I now have my biopsy results Gleason 3 + 4 ie 90% of 3 and 10% of 4 Grade 2 The consultant said it was Intermediate but at one point used the term Low intermediate. Is this latter term valid given the stats? T2a NO MO - but I am puzzled about this because although it was mostly all on the left side
I now have my biopsy results Gleason 3 + 4 ie 90% of 3 and 10% of 4 Grade 2 The consultant said it was Intermediate but at one point used the term Low intermediate. Is this latter term valid given the stats? T2a NO MO - but I am puzzled about this because although it was mostly all on the left side
Nordman
in
Advanced Prostate Cancer
7 months ago
psoas Muscle Tumors
my OVCA metastasized to my Psoas muscle 6 years after preliminary OVCA diagnosis. Various chemo and immunotherapy are helping keep it contained. Has anyone had surgery for removal of a psoas tumor? I’d love to hear from you. Thank you.
my OVCA metastasized to my Psoas muscle 6 years after preliminary OVCA diagnosis. Various chemo and immunotherapy are helping keep it contained. Has anyone had surgery for removal of a psoas tumor? I’d love to hear from you. Thank you.
Leniko
in
My Ovacome
7 months ago
Inulin
Hi AllLooking for some advice on Inulin...dietary fibre. Wondering wether to give it a go reading about it, seems to benefit just about everything!! Is it good for us 'Thyroids' though? Has anyone tried it? And does it cause bloatedness/flatulance/diarrhoea? If it helps constipation, cholesterol, belly
Hi AllLooking for some advice on Inulin...dietary fibre. Wondering wether to give it a go reading about it, seems to benefit just about everything!! Is it good for us 'Thyroids' though? Has anyone tried it? And does it cause bloatedness/flatulance/diarrhoea? If it helps constipation, cholesterol, belly
MissDemeanour191
in
Thyroid UK
5 months ago
Latest results - 6 weeks pregnant
Hello friends 😊 Following my last tests (a bit over 2 months ago), I added vitamin b12 drops 3 days a week, have cut down my B complex to 1 capsule, and I taking a separate Folate supplement as this was getting quite high, and it was pointed out to me that it is a "Goldilocks vitamin" when trying to
Hello friends 😊 Following my last tests (a bit over 2 months ago), I added vitamin b12 drops 3 days a week, have cut down my B complex to 1 capsule, and I taking a separate Folate supplement as this was getting quite high, and it was pointed out to me that it is a "Goldilocks vitamin" when trying to
Molly161018
in
Thyroid UK
5 months ago
What is the next step
I have one more Immunotherapy for my bladder cancer, so far all scan have shown no metastasis. Now I need to focus on my PC after more than a year of ignoring it. My PSA has been fluctuating and is now 0.65, doubling time is 16 months, I have not had ADT yet and my MO wants to just wait and watch. What
I have one more Immunotherapy for my bladder cancer, so far all scan have shown no metastasis. Now I need to focus on my PC after more than a year of ignoring it. My PSA has been fluctuating and is now 0.65, doubling time is 16 months, I have not had ADT yet and my MO wants to just wait and watch. What
old64horn
in
Advanced Prostate Cancer
7 months ago
Different Treatment Advice from Endocrinologist and Rheumatologist
Hello, I'm in my thirties and have osteoporosis. Earlier this year I saw an endocrinologist who advised I start HRT (my hormone levels are fine) and I have just seen a rheumatologist who advised I take alendronate. Neither can advise on the other. I wondered whether people had experience with either
Hello, I'm in my thirties and have osteoporosis. Earlier this year I saw an endocrinologist who advised I start HRT (my hormone levels are fine) and I have just seen a rheumatologist who advised I take alendronate. Neither can advise on the other. I wondered whether people had experience with either
Houseelf
in
Bone Health and Osteoporosis UK
9 months ago
Important caveat regarding estrogen therapy
Prof. Richard Wassersug tells me that estrogen therapy may be contraindicated if you have a BRCA 1 or 2 gene mutation. You can get a free, saliva germline genetic test of 30 genes from Color, Inc. as part of the PROMISE registry.
Prof. Richard Wassersug tells me that estrogen therapy may be contraindicated if you have a BRCA 1 or 2 gene mutation. You can get a free, saliva germline genetic test of 30 genes from Color, Inc. as part of the PROMISE registry.
janebob99
in
Prostate Cancer Network
7 months ago
Update: opinions please
Juat been told I have liw vitamin D.Could this be a reason my b12 was also low? I've read low vit D can effect B12 absorbtion. Is that correct?
Juat been told I have liw vitamin D.Could this be a reason my b12 was also low? I've read low vit D can effect B12 absorbtion. Is that correct?
Popcorn12345
in
Pernicious Anaemia Society
5 months ago
second recurrence
Hi ladies here I am again on my 2nd recurrence. A little bit unusual presentation as I complained of ongoing back pain had,had MRI and CT which had all been clear. Until the most recent scan showed a lymph node under my breast. They have not been able to biopsy it as I have just had a DVT and so I am
Hi ladies here I am again on my 2nd recurrence. A little bit unusual presentation as I complained of ongoing back pain had,had MRI and CT which had all been clear. Until the most recent scan showed a lymph node under my breast. They have not been able to biopsy it as I have just had a DVT and so I am
Hota
in
My Ovacome
7 months ago
hole in windpipe
I’m 3 years post Ivor Lewis, 2023 scan showed cancer in lymph node in neck had chemo and radiation, the radiation has now caused a hole in my windpipe that makes my saliva go down wrong pipe, causing chest infections just out of hospital after phenomena. Constant coughing . They first said could put
I’m 3 years post Ivor Lewis, 2023 scan showed cancer in lymph node in neck had chemo and radiation, the radiation has now caused a hole in my windpipe that makes my saliva go down wrong pipe, causing chest infections just out of hospital after phenomena. Constant coughing . They first said could put
Von66
in
Oesophageal & Gastric Cancer
5 months ago
Dense adhesions after 15 surgeries, + 2 rare medical conditions
At the age of 25, my life changed forever. After 4 years, 2 surgeries and no diagnosis, as to what the problems was, I eventually found out I had multiple intestinal lipomatosis and Ehlers Danlos Syndrome. Ileostomy formed 1996. 13 more surgeries have performed. Due to absorption problems, + major
At the age of 25, my life changed forever. After 4 years, 2 surgeries and no diagnosis, as to what the problems was, I eventually found out I had multiple intestinal lipomatosis and Ehlers Danlos Syndrome. Ileostomy formed 1996. 13 more surgeries have performed. Due to absorption problems, + major
Eegmetem
in
Pelvic Pain Support Network
5 months ago
Advice regarding alcohol and IBS!
I’m only 3 months into my possible IBS journey and am 6 days into a flare up. I did Dry February and was IBS free!! However we went on holiday and I had wine. Got back on Thursday and on Friday it started…has anyone noticed that alcohol exacerbates IBS? The doctor has given me mebeverine which might
I’m only 3 months into my possible IBS journey and am 6 days into a flare up. I did Dry February and was IBS free!! However we went on holiday and I had wine. Got back on Thursday and on Friday it started…has anyone noticed that alcohol exacerbates IBS? The doctor has given me mebeverine which might
Martini1
in
IBS Network
5 months ago
Vitamin B12 deficiency diagnosis and management - New NICE guidance
https://www.nice.org.uk/guidance/ng239/chapter/recommendations#recognising-vitamin-b12-deficiency
https://www.nice.org.uk/guidance/ng239/chapter/recommendations#recognising-vitamin-b12-deficiency
Pasionaria
in
Thyroid UK
5 months ago
Vitamins D and K7
I was diagnosed with hypothyroidism nine months ago, and prescribed 50mcg levothyroxine per day. No mention was made of Vitamin D results or any related issues like ferritin,or B12. I take Vitamin D 2200iu throughout Winter, and, as of October 23, after some online research, added Vitamin K2, 100 ug.
I was diagnosed with hypothyroidism nine months ago, and prescribed 50mcg levothyroxine per day. No mention was made of Vitamin D results or any related issues like ferritin,or B12. I take Vitamin D 2200iu throughout Winter, and, as of October 23, after some online research, added Vitamin K2, 100 ug.
lalage1979
in
Thyroid UK
5 months ago
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