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Low Testosterone reduces Survival by a huge amount.
This plot compares prostate cancer specific mortality probability versus time for two different levels of testosterone: Low and Normal. The low testosterone has a median value of 162 ng/dL [120-236] and the average normal T = 680 ng/dL. The cohort is 58 men with unfavorable intermediate risk who underwent
This plot compares prostate cancer specific mortality probability versus time for two different levels of testosterone: Low and Normal. The low testosterone has a median value of 162 ng/dL [120-236] and the average normal T = 680 ng/dL. The cohort is 58 men with unfavorable intermediate risk who underwent
janebob99
in
Prostate Cancer Network
7 months ago
My own PSA values over time: 70% drop in just 3 months on Dutasteride and no ADT
Here are my own PSA values versus time plot. You can see there is an exponential rise in PSA starting at around 6/1/23, and doubling from PSA = 5 to 10 in about 8 months. My MRI at PSA = 10 showed a T3a tumor about 1.3 cm long (PIRADS 5). A subsequent targeted biopsy showed Gleason 3+4 in 4 cores,
Here are my own PSA values versus time plot. You can see there is an exponential rise in PSA starting at around 6/1/23, and doubling from PSA = 5 to 10 in about 8 months. My MRI at PSA = 10 showed a T3a tumor about 1.3 cm long (PIRADS 5). A subsequent targeted biopsy showed Gleason 3+4 in 4 cores,
janebob99
in
Prostate Cancer Network
7 months ago
Doubling Times and PSA acceleration - Part II
This is a more realistic schematic plot of PSA levels increasing over time at an ever faster rate (acceleration). What could cause this? My theory is that as the tumor grows, the number of androgen receptors (ARs) increases proportionally. That makes sense...more PCa cells inside a tumor...more ARs
This is a more realistic schematic plot of PSA levels increasing over time at an ever faster rate (acceleration). What could cause this? My theory is that as the tumor grows, the number of androgen receptors (ARs) increases proportionally. That makes sense...more PCa cells inside a tumor...more ARs
janebob99
in
Prostate Cancer Network
7 months ago
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EBRT - Is it the right thing and what to expect?
After DX in November 2018 with Stage IV and Gleason of 5+4 and 4+5, and 5 years of ADT of Lupron (then Orgovyx), prednisone 5mg, and Zytiga 250mg with low fat breakfast, my PSA stayed stable at 0.4 or 0.5. At end of 2013, PSA started rising to latest value of 0.84. Had PSMA PET Scan March 5, 2024
After DX in November 2018 with Stage IV and Gleason of 5+4 and 4+5, and 5 years of ADT of Lupron (then Orgovyx), prednisone 5mg, and Zytiga 250mg with low fat breakfast, my PSA stayed stable at 0.4 or 0.5. At end of 2013, PSA started rising to latest value of 0.84. Had PSMA PET Scan March 5, 2024
JazzMan42
in
Advanced Prostate Cancer
6 months ago
Targeted Gene Therapy for Symptom Relief in Parkinson’s Disease
Very early, still a looooong way out, and results were only in animal models, but something to keep an eye on. https://www.brainpost.co/weekly-brainpost/2023/11/7/targeted-gene-therapy-for-symptom-relief-in-parkinsons-disease
Very early, still a looooong way out, and results were only in animal models, but something to keep an eye on. https://www.brainpost.co/weekly-brainpost/2023/11/7/targeted-gene-therapy-for-symptom-relief-in-parkinsons-disease
Neurosmith
in
Cure Parkinson's
11 months ago
Non metastasis castrate resistant
When you are on ADT and become Non metastatic Castrate resistant and your testosterone levels are below zero, what is the cancer feeding off to cause the PSA to still rise? Hoping for your replies so as to give me some understanding. Thank you.
When you are on ADT and become Non metastatic Castrate resistant and your testosterone levels are below zero, what is the cancer feeding off to cause the PSA to still rise? Hoping for your replies so as to give me some understanding. Thank you.
Sailameme
in
Advanced Prostate Cancer
7 months ago
help with bloods.
I have been on HRT for 5 years. I'm currently on 300mg Utrogestan (100mg to 200mg 17/10 then 200mg 25 on 3 days off then up to 300mg on 11/2/24 25 days on 3 days off) and 100 evorel patch plus 1 pump of tostran gel twice a week. I have been having bleeds since June 23 (had an internal scan and biopsy
I have been on HRT for 5 years. I'm currently on 300mg Utrogestan (100mg to 200mg 17/10 then 200mg 25 on 3 days off then up to 300mg on 11/2/24 25 days on 3 days off) and 100 evorel patch plus 1 pump of tostran gel twice a week. I have been having bleeds since June 23 (had an internal scan and biopsy
WendyW1964
in
Menopause and Perimenopause Support
7 months ago
post menopause bleeding
Hi all, I’m a 64 year old woman whose periods stopped when I was 50, I chose HRT after a few years of non stop daytime sweats, zero concentration and bursting into tears at the drop of a hat 🙈 I stopped the HRT back in 2020 but had to start it again last year as the sweats returned with a vengeance
Hi all, I’m a 64 year old woman whose periods stopped when I was 50, I chose HRT after a few years of non stop daytime sweats, zero concentration and bursting into tears at the drop of a hat 🙈 I stopped the HRT back in 2020 but had to start it again last year as the sweats returned with a vengeance
NanaFifi
in
Women's Health
7 months ago
women of a certain age
ok so it may be time to accept the fact that it may not be just my thyroid causing my issues.?so I’ve read quite a lot about her and think as I didn’t have a good run with levothyroxine I don’t think combining hrt tables as well is the way to go so after reading lots I’m thinking get with a progesterone
ok so it may be time to accept the fact that it may not be just my thyroid causing my issues.?so I’ve read quite a lot about her and think as I didn’t have a good run with levothyroxine I don’t think combining hrt tables as well is the way to go so after reading lots I’m thinking get with a progesterone
Bobby25
in
Thyroid UK
7 months ago
Just some new Information about AI
Came across this article a couple days ago. https://www.news-medical.net/news/20210924/Researchers-identify-two-subtypes-of-metastatic-prostate-cancer.aspx#:~:text=Building%20off%20of%20earlier%20studies%20that%20discovered%20clinically,into%20two%20types%20known%20as%20luminal%20and%20basal AI has
Came across this article a couple days ago. https://www.news-medical.net/news/20210924/Researchers-identify-two-subtypes-of-metastatic-prostate-cancer.aspx#:~:text=Building%20off%20of%20earlier%20studies%20that%20discovered%20clinically,into%20two%20types%20known%20as%20luminal%20and%20basal AI has
chefjlu
in
Advanced Prostate Cancer
7 months ago
Revised Plot of PSA vs Testosterone: Estrogen vs Lupron ADT
Ugh...I made a BIG mistake on the previous posting! I just realized that Dr. Morgentaler had listed the Testosterone level in unusual units (
ng/mL
), not the usual units of (
ng/dL)
. So, my X-axis was off by a factor of 10. Here is the revised plot. The exciting discovery is that the
Ugh...I made a BIG mistake on the previous posting! I just realized that Dr. Morgentaler had listed the Testosterone level in unusual units (
ng/mL
), not the usual units of (
ng/dL)
. So, my X-axis was off by a factor of 10. Here is the revised plot. The exciting discovery is that the
janebob99
in
Advanced Prostate Cancer
7 months ago
Morgentaler Saturation Model: PSA vs Testosterone - Estrogen Patch vs Lupron ADT
This is a plot of % reduction in PSA from a Maximum Value versus Testosterone, for two different datasets: Estrogen Patch and Lupron ADT. Both curves (red and green lines) show a linear response starting from (0,0), up to about 200-250 ng/dL. Then, the lines curve over to a lower slope (especially
This is a plot of % reduction in PSA from a Maximum Value versus Testosterone, for two different datasets: Estrogen Patch and Lupron ADT. Both curves (red and green lines) show a linear response starting from (0,0), up to about 200-250 ng/dL. Then, the lines curve over to a lower slope (especially
janebob99
in
Advanced Prostate Cancer
7 months ago
Another brother passes
My friend, George, passed this morning after a two year battle. He was DX'd at 85 with prostate cancer (PSA of 1200) behind his eye which spread to his brain. Failed ADT, chemo and Pluvicto. He was not on this forum. He was very active, skied 120 days a year, biked the rest. He and his wife went to
My friend, George, passed this morning after a two year battle. He was DX'd at 85 with prostate cancer (PSA of 1200) behind his eye which spread to his brain. Failed ADT, chemo and Pluvicto. He was not on this forum. He was very active, skied 120 days a year, biked the rest. He and his wife went to
gsun
in
Advanced Prostate Cancer
7 months ago
Occupational therapy intervention for FND
Would anyone like to share their experiences of occupation therapy intervention for FND, especially in relation to the mitigation of shaking, vocalisations, and hypersensitivity to noise. How helpful did you find it?
Would anyone like to share their experiences of occupation therapy intervention for FND, especially in relation to the mitigation of shaking, vocalisations, and hypersensitivity to noise. How helpful did you find it?
Shimmyaway
in
Functional Neurological Disorder - FND Hope
11 months ago
PSMA Scan to be scheduled - thank you Tall Allen
I want to thank Tall Allen for his suggestion that I see an oncologist. I had a RP followed by radiation in 2013. My PSA was undetectable until 2021, when it started to rise. This week I saw a radiation oncologist (whom I found through a friend) to ask him a lot of questions and to get his advice.
I want to thank Tall Allen for his suggestion that I see an oncologist. I had a RP followed by radiation in 2013. My PSA was undetectable until 2021, when it started to rise. This week I saw a radiation oncologist (whom I found through a friend) to ask him a lot of questions and to get his advice.
Geno2853
in
Advanced Prostate Cancer
7 months ago
PSA-Nadir vs Testosterone-Nadir comparing Non-CRPC to CRPX men
These plots show the linear relationship between median PSA-Nadir and median Testosterone-Nadir, pointing towards the Origin (i.e., 0 PSA-Nadir at 0 T-Nadir.). N= 38 men. The upper to graphs compare median PSA-nadir and median T-Nadir for Non-CRPC and CPRC groups (CPRC = Castrate Resistant Prostate
These plots show the linear relationship between median PSA-Nadir and median Testosterone-Nadir, pointing towards the Origin (i.e., 0 PSA-Nadir at 0 T-Nadir.). N= 38 men. The upper to graphs compare median PSA-nadir and median T-Nadir for Non-CRPC and CPRC groups (CPRC = Castrate Resistant Prostate
janebob99
in
Advanced Prostate Cancer
7 months ago
PSA-Nadir vs Testosterone-Nadir
These plots show the linear relationship between median PSA-Nadir and median Testosterone-Nadir, pointing towards the Origin (i.e., 0 PSA-Nadir at 0 T-Nadir.). N= 38 men. The upper to graphs compare median PSA-nadir and median T-Nadir for Non-CRPC and CPRC groups (CPRC = Castrate Resistant Prostate
These plots show the linear relationship between median PSA-Nadir and median Testosterone-Nadir, pointing towards the Origin (i.e., 0 PSA-Nadir at 0 T-Nadir.). N= 38 men. The upper to graphs compare median PSA-nadir and median T-Nadir for Non-CRPC and CPRC groups (CPRC = Castrate Resistant Prostate
janebob99
in
Prostate Cancer Network
7 months ago
Joint pain
Hi I have a history of back pain due to bulges bit more recently joint pain in lower back. The consultant has said some degeneration found but everyone has that. We are now looking at more spinal injections and further treatment.I am in perimenopause and have been on hrt for 2 years. Everol Patches and
Hi I have a history of back pain due to bulges bit more recently joint pain in lower back. The consultant has said some degeneration found but everyone has that. We are now looking at more spinal injections and further treatment.I am in perimenopause and have been on hrt for 2 years. Everol Patches and
AMS_1
in
Menopause and Perimenopause Support
7 months ago
ADT response and questions for MO
Hi, I am newish to this forum, still on a steep learning curve but I want to thank you for your contributions and discussions. This is my first time posting. My partner is 60 yrs old, as I understand it he had low PSA 3 yrs ago, not tested until Nov 2023, PSA50, stage 4, 1 met in 'sit' bone. Started
Hi, I am newish to this forum, still on a steep learning curve but I want to thank you for your contributions and discussions. This is my first time posting. My partner is 60 yrs old, as I understand it he had low PSA 3 yrs ago, not tested until Nov 2023, PSA50, stage 4, 1 met in 'sit' bone. Started
Lovecherries
in
Advanced Prostate Cancer
7 months ago
One questions doctors never seem to be able to answer is at what PSA level do you start to experience pain or physical problems?
One questions doctors never seem to be able to answer is at what PSA level do you start to experience pain or physical problems? If you have had surgery, Salvage Radiation, ADT, SRBT and then stopped ADT with a continuing rise in you PSA when did you start to have pain or physical problems?
One questions doctors never seem to be able to answer is at what PSA level do you start to experience pain or physical problems? If you have had surgery, Salvage Radiation, ADT, SRBT and then stopped ADT with a continuing rise in you PSA when did you start to have pain or physical problems?
Exrunner
in
Advanced Prostate Cancer
7 months ago
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