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Uric Acid: A Double Edged Sword
From a study on Pubmed - Uric Acid (UA), historically considered as a waste of cellular metabolism, has now received increasing attention because it was found to directly participate in the pathogenesis of many human diseases including neurological disorders. On one hand, low levels of UA are detrimental
From a study on Pubmed - Uric Acid (UA), historically considered as a waste of cellular metabolism, has now received increasing attention because it was found to directly participate in the pathogenesis of many human diseases including neurological disorders. On one hand, low levels of UA are detrimental
Hidden
in
Cure Parkinson's
3 years ago
High uric acid diet for PD?
My husband had his uric acid tested recently and it was out of range low, lower than even the medians for PD patients in most of the uric acid studies on Pubmed. He has been eating a diet to raise his uric acid levels and testing his uric acid at home with test strips I bought on Amazon. He feels
My husband had his uric acid tested recently and it was out of range low, lower than even the medians for PD patients in most of the uric acid studies on Pubmed. He has been eating a diet to raise his uric acid levels and testing his uric acid at home with test strips I bought on Amazon. He feels
Hidden
in
Cure Parkinson's
3 years ago
Colchicine for Gout at base of big toe
I have possible gout or arthritis at base of big toe which has come on suddenly. My Gp has given me 12 Colchicine 500 ug. Ive taken 3 spaced out in 19 hrs, first one at 3pm yesterday. As they can be toxic i'll take another this evening but i dont appear to have any side effects! Very painful and ive
I have possible gout or arthritis at base of big toe which has come on suddenly. My Gp has given me 12 Colchicine 500 ug. Ive taken 3 spaced out in 19 hrs, first one at 3pm yesterday. As they can be toxic i'll take another this evening but i dont appear to have any side effects! Very painful and ive
Ainsdale2010
in
Arthritis Action
3 years ago
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The Thermodynamic Consequences of Parkinson's Disease
Several lines of evidence point to a pervasive disturbance of energy balance in Parkinson's disease (PD). Weight loss, common and multifactorial, is the most observable sign of this. Bradykinesia may be best understood as an underinvestment of energy in voluntary movement. This accords with rodent experiments
Several lines of evidence point to a pervasive disturbance of energy balance in Parkinson's disease (PD). Weight loss, common and multifactorial, is the most observable sign of this. Bradykinesia may be best understood as an underinvestment of energy in voluntary movement. This accords with rodent experiments
Farooqji
in
Cure Parkinson's
3 years ago
Idebenone can be toxic or beneficial depending on its oxidation-reduction state.
Idebenone is a CoQ10 clone that is smaller and will pass the BBB. I have some and have taken it a few times but I don't anymore. Every once and awhile I reconsider it. Not going to be restarting it this week. Just too many question marks. The effects of idebenone on mitochondrial bioenergetics 2012
Idebenone is a CoQ10 clone that is smaller and will pass the BBB. I have some and have taken it a few times but I don't anymore. Every once and awhile I reconsider it. Not going to be restarting it this week. Just too many question marks. The effects of idebenone on mitochondrial bioenergetics 2012
Bolt_Upright
in
Cure Parkinson's
3 years ago
Movelat cream v Edoxaban
My GP has prescribed Movelat cream for me. I am on Edoxaban 60 mg plus Bisoprolol 2.5 mg for AF. GP says it's okay to use the cream but pharmacist says it may conflict with my anticoagulants. W hat should I do. No help on the internet.
My GP has prescribed Movelat cream for me. I am on Edoxaban 60 mg plus Bisoprolol 2.5 mg for AF. GP says it's okay to use the cream but pharmacist says it may conflict with my anticoagulants. W hat should I do. No help on the internet.
Aniela
in
AF Association
3 years ago
It seems to be working
Well guess what, when Myhubby58 was in the delirium stage, the Hospice Nurse figured out it was the lorazepam that was making him have hallucinations. And now that she took him off of that, he is no longer having them.. Thank You Jesus.. Now they have him on dextamethazone, methadone, and oxycodene,
Well guess what, when Myhubby58 was in the delirium stage, the Hospice Nurse figured out it was the lorazepam that was making him have hallucinations. And now that she took him off of that, he is no longer having them.. Thank You Jesus.. Now they have him on dextamethazone, methadone, and oxycodene,
Myhubby58
in
Advanced Prostate Cancer
3 years ago
Calquence and muscle/joint pain
Hi all, After a week on Calquence, my hubs is in excruciating pain - from the hips down. Can barely walk, can't sleep, etc. The pharmacist thinks this is a side effect from the Calquence. He's been taking hydrocodone left over from a procedure and I'm applying BioFreeze, which sort of takes the edge
Hi all, After a week on Calquence, my hubs is in excruciating pain - from the hips down. Can barely walk, can't sleep, etc. The pharmacist thinks this is a side effect from the Calquence. He's been taking hydrocodone left over from a procedure and I'm applying BioFreeze, which sort of takes the edge
qtrhorsechic
in
CLL Support
3 years ago
Do medium-chain triglycerides downregulate mTOR?
I ran across some info about MCTs turning off mTOR and amping up AMPK (possibly resulting in an increase in autophagy and also lipolysis). Does anyone have any info on whether or not MCTs are potentially beneficial for prostate cancer?
I ran across some info about MCTs turning off mTOR and amping up AMPK (possibly resulting in an increase in autophagy and also lipolysis). Does anyone have any info on whether or not MCTs are potentially beneficial for prostate cancer?
Hidden
in
Advanced Prostate Cancer
3 years ago
Does PV or taking HU cause gout
Hello and thank you to everyone who answered my question about Hu and sun exposure, will have a few more questions when I visit the heme this week. I am 71 PV and just started HU 10 days ago will see the results late this week. I was given a prescription for allopurinol at the same time as I was given
Hello and thank you to everyone who answered my question about Hu and sun exposure, will have a few more questions when I visit the heme this week. I am 71 PV and just started HU 10 days ago will see the results late this week. I was given a prescription for allopurinol at the same time as I was given
Meatloaf9
in
MPN Voice
3 years ago
Switching from Eliquis to a one a day 325mg Aspirin
Hi guys, just curious, Has anybody been on Eliquis and then changed to one aspirin 325 mg a day instead? I was diagnosed with Afib in 2018 but have maybe one episode a year so my Dr. told me to switch from Eliquis to one 325mg aspirin a day. I am concerned that the aspirin won’t thin my blood enough
Hi guys, just curious, Has anybody been on Eliquis and then changed to one aspirin 325 mg a day instead? I was diagnosed with Afib in 2018 but have maybe one episode a year so my Dr. told me to switch from Eliquis to one 325mg aspirin a day. I am concerned that the aspirin won’t thin my blood enough
ecdiener
in
AF Association
3 years ago
KT/V Test
I recently took Another KT/V and it came back below passing… with that being said I’m set to retake it again next week and if I don’t get a passing number on this next one then they will put me back on Hemodialysis which I feel will be a death sentence because I went to PD because the staff that worked
I recently took Another KT/V and it came back below passing… with that being said I’m set to retake it again next week and if I don’t get a passing number on this next one then they will put me back on Hemodialysis which I feel will be a death sentence because I went to PD because the staff that worked
Vacuumnerd
in
Dialysis Support
3 years ago
Do you feel jelly lately? Try Koko Jelly Dessert. 😉😋❤️🌺
Happy Tuesday everyone! Hope your day is joyful so far! 🤗 I had leftovers for food so I decided to make some yummy jelly. 😋 Main ingredients: Clear Gelatin, purée passion fruits, mangos, maple syrup and coconut milk. It’s any clear gelatin you can get from supermarket. The key is creating layer by
Happy Tuesday everyone! Hope your day is joyful so far! 🤗 I had leftovers for food so I decided to make some yummy jelly. 😋 Main ingredients: Clear Gelatin, purée passion fruits, mangos, maple syrup and coconut milk. It’s any clear gelatin you can get from supermarket. The key is creating layer by
Hidden
in
Healthy Eating
3 years ago
Stopped taking allopurinol
Had allopurinol for over twenty years for gout buy not had a attack for 19 years stopped taking seven months ago not had a attack had heal pain worried was gout but surely I'd have had a attack earlier than seven months in???
Had allopurinol for over twenty years for gout buy not had a attack for 19 years stopped taking seven months ago not had a attack had heal pain worried was gout but surely I'd have had a attack earlier than seven months in???
Hidden
in
CLL Support
3 years ago
Xylitol for teeth
Whilst Xylitol may be equivalent to Mannitol for increasing butyrate, I would like to commend it for its ability to fight tooth decay. Of course you can chew gum containing Xylitol, but it is not recommended if you have mercury amalgam fillings. Just dissolve half a teaspoon round your mouth after each
Whilst Xylitol may be equivalent to Mannitol for increasing butyrate, I would like to commend it for its ability to fight tooth decay. Of course you can chew gum containing Xylitol, but it is not recommended if you have mercury amalgam fillings. Just dissolve half a teaspoon round your mouth after each
alexask
in
Cure Parkinson's
3 years ago
Venetoclax and tiredness
Hi, I'm on week four of the ramp up. My bloods are good but since I've upped the dosage to 200mg I've noticed an increase in drowsiness. I nearly always fall asleep about an hour after taking the dose of Venetoclax and allopurinol. I'm so disappointed as the whole reason I'm being treated is because
Hi, I'm on week four of the ramp up. My bloods are good but since I've upped the dosage to 200mg I've noticed an increase in drowsiness. I nearly always fall asleep about an hour after taking the dose of Venetoclax and allopurinol. I'm so disappointed as the whole reason I'm being treated is because
Kenn123
in
CLL Support
3 years ago
Nefopam for pred replacement ?
Hello all, After being on pred (7mg) for the past four years, my rhumi insists it can't be pmr as I'd have been cured by now :-( I realise from here that this is not always the case. He has prescribed nefopam to take whilst reducing preds. However, nefo is not agreeing with me at all, I struggle with
Hello all, After being on pred (7mg) for the past four years, my rhumi insists it can't be pmr as I'd have been cured by now :-( I realise from here that this is not always the case. He has prescribed nefopam to take whilst reducing preds. However, nefo is not agreeing with me at all, I struggle with
RevSmallwood
in
PMRGCAuk
3 years ago
Jakavi. - PV
Hi … can anyone tell me “why” jakavi is easily accessible and affordable in the U.K. ??? Or even Europe????? Would really like to know … I’m in Ontario Canada and my hematologist is close to preparing to plead with our government to allow me to have jakavi on compassionate grounds because my “pinching
Hi … can anyone tell me “why” jakavi is easily accessible and affordable in the U.K. ??? Or even Europe????? Would really like to know … I’m in Ontario Canada and my hematologist is close to preparing to plead with our government to allow me to have jakavi on compassionate grounds because my “pinching
Hidden
in
MPN Voice
3 years ago
Hexose-6-phosphate dehydrogenase blockade reverses enzalutamide resistance
New Paper: “Hexose-6-phosphate dehydrogenase blockade reverses prostate cancer drug resistance in xenograft models by glucocorticoid inactivation” https://stm.sciencemag.org/content/13/595/eabe8226
New Paper: “Hexose-6-phosphate dehydrogenase blockade reverses prostate cancer drug resistance in xenograft models by glucocorticoid inactivation” https://stm.sciencemag.org/content/13/595/eabe8226
SimonHL
in
Advanced Prostate Cancer
3 years ago
Navigating endometriosis naturally
I take ashwaganda and I've been recommended
gotu
kola
. I've had major break through moments, with 6 months pain free all through the above techniques and would like to let you know that this is possible because there was noone there to let me know this and I was stuck in a medical system.
I take ashwaganda and I've been recommended
gotu
kola
. I've had major break through moments, with 6 months pain free all through the above techniques and would like to let you know that this is possible because there was noone there to let me know this and I was stuck in a medical system.
Mimorais
in
Endometriosis UK
3 years ago
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