Do medium-chain triglycerides downregulate mTOR?

I ran across some info about MCTs turning off mTOR and amping up AMPK (possibly resulting in an increase in autophagy and also lipolysis). Does anyone have any info on whether or not MCTs are potentially beneficial for prostate cancer?

[tango65]

Do you have a link?

[Hidden in reply to tango65]

I saw it on youtube. Yeah. I get it.

When I look for studies I only see the exact opposite of the scientific youtube.

pubmed.ncbi.nlm.nih.gov/237...

ncbi.nlm.nih.gov/pmc/articl...

The evidence appears scanty so, unless I see more robust data, I'm going to shelve this under the bro-science and manufacturer greed categories.

[Justfor_]

I know that in my case my DHT has a closer correlation to my TG than to my total T. The latter has closer correlation to total Cholesterol and LDL. If the assertion that DHT is the prime fuel feeding PCa has even a slight shred of evidence, two conclusions can be drawn for my case. First, keep TG as low as possible. Patrick has set this value to less than 100. Second, all these docs that only test tT and believe that DHT is a small portion of it are for the dogs. My tT to DHT correlation coefficient R is somewhere around 0.25, a value more suited to independent, aka NOT-correlated, variables. The DHT test cost here is 14 to 30 Euros, depending on lab and if ordered separately or as part of a broader panel of blood tests.

[Hidden in reply to Justfor_]

My DHT levels might correlate to my triglycerides.

I take dutasteride and finasteride to reduce my DHT. I went off of both for a few months and my TG shot up. I reduced my intake of fruit (fructose) and, around the same time, I started the duta and fina again. My TG went down considerably. N of 1, confounded variables, and only one lab pre-test and a few lab post-tests.

[Spyder54]

This article helped me catch up on MCT’s and LCT’s and its relationship to how we process.health.usnews.com/health-ne...

[Spyder54]

Didnt know mTOR stands for Mammalian target of Rapomycin.

[Spyder54 in reply to Spyder54]

Now understand your question better for all of us with only little Biology backgrounds:History[edit]The discovery of mTOR was made a few decades ago while investigating the mechanism of action of its inhibitor, rapamycin.[2][3] Rapamycin was first discovered in 1975 in a soil sample from Easter Island of South Pacific, also known as Rapa Nui, from where its name is derived.[4] Rapamycin is a macrolide, produced by the microorganism Streptomyces hygroscopicus and showed antifungal properties. Shortly after its discovery, immunosuppressive properties were detected, which later led to the establishment of rapamycin as an immunosuppressant. In the 1980s, rapamycin was also found to have anticancer activity although the exact mechanism of action remained unknown until many years later.[2][5][6]

In the 1990s there was a dramatic change in this field due to studies on the mechanism of action of rapamycin and the identification of the drug target.[4] It was found that rapamycin inhibited cellular proliferation and cell cycle progression. Research on mTOR inhibition has been a growing branch in science and has promising results.[7]

[Hidden in reply to Spyder54]

My NMD prescribed Sirolimus (Rapamycin). Low dose: 2 mg a week.

ncbi.nlm.nih.gov/pmc/articl...

[pjoshea13 in reply to Spyder54]

I have always found the name amusing. Wiki:

"... the molecular target of the FKBP12-rapamycin complex in mammals was not known. In 1994, Stuart L. Schreiber, David M. Sabatini and Robert T. Abraham independently discovered a protein that directly interacts with FKBP12-rapamycin, which became known as mTOR ..."

As though this thing that was found in the dirt on Easter Island must have a mammalian target!

But indeed it did. They discovered a new protein (no name) that was the target. Was it just sitting around waiting for discovery & a cute name?

mTOR is also called: "mechanistic target of rapamycin"