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Gaucher disease type 1 (GD1)
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Targeting the glutamine metabolism to suppress cell proliferation in mesenchymal docetaxel-resistant prostate cancer
Source Link : https://www.nature.com/articles/s41388-024-03059-4 Docetaxel (DX) serves as a palliative treatment option for metastatic prostate cancer (PCa). Despite initial remission, acquired DX resistance is inevitable. The mechanisms behind DX resistance have not yet been deciphered, but a mesenchymal
Source Link : https://www.nature.com/articles/s41388-024-03059-4 Docetaxel (DX) serves as a palliative treatment option for metastatic prostate cancer (PCa). Despite initial remission, acquired DX resistance is inevitable. The mechanisms behind DX resistance have not yet been deciphered, but a mesenchymal
God_Loves_Me
in
Advanced Prostate Cancer
3 months ago
Low protein
Hello,My husband has bloods done yesterday around lunch time by 6pm the GP called saying he had worrying results and thr protein levels in his blood are very low, he has decompensated liver cirrhosis, the doctor didn't say much else so I don't really understand, the only other thing he said was that
Hello,My husband has bloods done yesterday around lunch time by 6pm the GP called saying he had worrying results and thr protein levels in his blood are very low, he has decompensated liver cirrhosis, the doctor didn't say much else so I don't really understand, the only other thing he said was that
Hithereeveryone
in
British Liver Trust
3 months ago
every test under the sun but no apparent cause for elevated liver numbers
Hi. I’m posting for a friend in case anyone here has experienced something similar. She’s in her early 30s and healthy. her liver panel shows elevated numbers but she has no fatty liver, negative for any hep c/b, has done all liver related autoimmune tests and all are negative. Has been to a few centers
Hi. I’m posting for a friend in case anyone here has experienced something similar. She’s in her early 30s and healthy. her liver panel shows elevated numbers but she has no fatty liver, negative for any hep c/b, has done all liver related autoimmune tests and all are negative. Has been to a few centers
Lulla
in
British Liver Trust
3 months ago
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I thought I knew about ablation…this is a new ball game
help guys! last ablation must have been a breeze apart from energy loss. This one is awgul so far. Walking to the loo is about my limit, fair enough, but on the three hour drive home I started to get pains . My throat whivh already hurt from the start, hurst now all the way down to my lungs when I
help guys! last ablation must have been a breeze apart from energy loss. This one is awgul so far. Walking to the loo is about my limit, fair enough, but on the three hour drive home I started to get pains . My throat whivh already hurt from the start, hurst now all the way down to my lungs when I
Morzine
in
Atrial Fibrillation Support
3 months ago
Toronto Prostate Cancer Specialist for Dad
My dad (68 years old) is visiting me (For my delivery in the first week of June) from India and he is going to be in Ontario, Canada for the next 3 months. He was diagnosed in Feb 2024 with a PSA of 24 and is completely asymptomatic. He is on hormone therapy with Gleason 8 and distant mets in his bones
My dad (68 years old) is visiting me (For my delivery in the first week of June) from India and he is going to be in Ontario, Canada for the next 3 months. He was diagnosed in Feb 2024 with a PSA of 24 and is completely asymptomatic. He is on hormone therapy with Gleason 8 and distant mets in his bones
Justgettingitright
in
Advanced Prostate Cancer
3 months ago
Wednesday's Word
[u][i]
albumin
[/i][/u]
-
This is a protein made by the liver, the level of which is measured as a part of your liver function tests. The albumin plays 2 important parts: 1. It carries molecules in the blood that are not water soluable. When bound to albumin, the molecule becomes water
[u][i]
albumin
[/i][/u]
-
This is a protein made by the liver, the level of which is measured as a part of your liver function tests. The albumin plays 2 important parts: 1. It carries molecules in the blood that are not water soluable. When bound to albumin, the molecule becomes water
DonnaBoll
Administrator
in
PBC Foundation
3 months ago
advice on synacthen test
for anyone who has been following my story they will know I’ve been having medication issues and I am now taking T3 only. Still having issues with weight gain. Spoke to my endocrinologist last week and she has agreed the increase to 40mcg. This was after she had suggested trying a small dose of levothyroxine
for anyone who has been following my story they will know I’ve been having medication issues and I am now taking T3 only. Still having issues with weight gain. Spoke to my endocrinologist last week and she has agreed the increase to 40mcg. This was after she had suggested trying a small dose of levothyroxine
ScriptMaz
in
Thyroid UK
3 months ago
Update, small cell
Hi everyone, It's been a while since I posted but check in time to time. I'm not really sure of the purpose of this update is except we don't have a lot of family so I'm hoping writing it down will help. Please be sensitive as I'm struggling. I really can't hear about should of dones. My husband was
Hi everyone, It's been a while since I posted but check in time to time. I'm not really sure of the purpose of this update is except we don't have a lot of family so I'm hoping writing it down will help. Please be sensitive as I'm struggling. I really can't hear about should of dones. My husband was
Fdccs
in
Advanced Prostate Cancer
3 months ago
spider nevi?
Hello I have recently been pregnant and I am now breastfeeding my third child. I used to drink too much alcohol but I don't anymore. For some time now I have had a rash, in the face mostly. is it a spider nevi? can't see a central point but small veins. am of course worried that my past sins may have
Hello I have recently been pregnant and I am now breastfeeding my third child. I used to drink too much alcohol but I don't anymore. For some time now I have had a rash, in the face mostly. is it a spider nevi? can't see a central point but small veins. am of course worried that my past sins may have
Spider2
in
British Liver Trust
3 months ago
pale stool after yellow diarrhea
I’ve been high anxiety googling why pale stool for a couple days now following bout of yellowish diarrhea. anyone had this symptom? going to quit alcohol for good (I’ve gone years at times other 10 months, others a few…) baffling why I put myself through this worry and multiple times now. After a few
I’ve been high anxiety googling why pale stool for a couple days now following bout of yellowish diarrhea. anyone had this symptom? going to quit alcohol for good (I’ve gone years at times other 10 months, others a few…) baffling why I put myself through this worry and multiple times now. After a few
Mtseagirl
in
British Liver Trust
3 months ago
refusing treatment how fast do people decline?
hubby has ARLD he was on the transplant list but took himself off due to PTSD. He is not drunk alcohol for two years since he was first hospitalised with decompensated liver he has no acides or varies for the last 18 months. he has had HE the whole time and is treated for this. he was doing okay. He
hubby has ARLD he was on the transplant list but took himself off due to PTSD. He is not drunk alcohol for two years since he was first hospitalised with decompensated liver he has no acides or varies for the last 18 months. he has had HE the whole time and is treated for this. he was doing okay. He
Bluescarf123
in
British Liver Trust
3 months ago
In vivo/vitro: Dickkopf-1 (DKK1) drives growth and metastases in castration-resistant prostate cancer
...does "kopf" mean head? because I could switch to call my cancer dickkopf in that case! Anyway, thanks to CRISPR we have discovered another pathway...they have discovered another pathway! https://communities.springernature.com/posts/dickkopf-1-dkk1-drives-growth-and-metastases-in-castration-resistant-prostate-cancer
...does "kopf" mean head? because I could switch to call my cancer dickkopf in that case! Anyway, thanks to CRISPR we have discovered another pathway...they have discovered another pathway! https://communities.springernature.com/posts/dickkopf-1-dkk1-drives-growth-and-metastases-in-castration-resistant-prostate-cancer
Maxone73
in
Advanced Prostate Cancer
3 months ago
Next step
Just finished up with chemo. Went from 139 psa @ dx to 1.66. I didn't make it to the non detectable team. Not sure what to think as many here with higher psa's have gone down lower. I'm currently still on Orgovyx and Nubeqa. Should I ask for more rounds of chemo as I've done 6 ? Will my PSA possibly
Just finished up with chemo. Went from 139 psa @ dx to 1.66. I didn't make it to the non detectable team. Not sure what to think as many here with higher psa's have gone down lower. I'm currently still on Orgovyx and Nubeqa. Should I ask for more rounds of chemo as I've done 6 ? Will my PSA possibly
APK3
in
Advanced Prostate Cancer
3 months ago
Found a Reliable Place to Buy Enzalutamide Prostate Cancer Medication at Low Price
I found a trustworthy place to purchase Enzalutamide, a medication for prostate cancer, at a fair price. I bought it from Oddway International, an Indian pharmaceutical distributor. They were really helpful and answered all my questions patiently. The medicine arrived on time and at a price I could afford
I found a trustworthy place to purchase Enzalutamide, a medication for prostate cancer, at a fair price. I bought it from Oddway International, an Indian pharmaceutical distributor. They were really helpful and answered all my questions patiently. The medicine arrived on time and at a price I could afford
davidjroberts
in
Fight Prostate Cancer
3 months ago
High temperature
Hi everyone,I am a bit lost about what is happening and doctors do not seem to give clear answers. My mum has been on Dialysis for a few years and suddenly recently she started having a high temperature after dialysis which disappears the day after but comes back after another dialysis again. She has
Hi everyone,I am a bit lost about what is happening and doctors do not seem to give clear answers. My mum has been on Dialysis for a few years and suddenly recently she started having a high temperature after dialysis which disappears the day after but comes back after another dialysis again. She has
OggieSh
in
Kidney Dialysis
3 months ago
Abdominal burning pain
Do people suffer with burning pain, a bit like IBS pain, but more constant and burning anywhere across the abdomen. I am still awaiting tests to confirm PA, but I know I have a very high pH, so almost no stomach acid, which is obviously causing the pain. I eat a varied diet, not much in the way of processed
Do people suffer with burning pain, a bit like IBS pain, but more constant and burning anywhere across the abdomen. I am still awaiting tests to confirm PA, but I know I have a very high pH, so almost no stomach acid, which is obviously causing the pain. I eat a varied diet, not much in the way of processed
Chickens44
in
Pernicious Anaemia Society
3 months ago
My up and down PSA levels.
On this journey I have had an up and down PSA level. My first indication was of 107 . With various drugs and 25 sessions of radiation,PSA was down to .075. That was November 23.December 23...PSA 18 Consultant told me my prostate had metastasize in to my lung. PSA rose to 117...started chemo March 23.
On this journey I have had an up and down PSA level. My first indication was of 107 . With various drugs and 25 sessions of radiation,PSA was down to .075. That was November 23.December 23...PSA 18 Consultant told me my prostate had metastasize in to my lung. PSA rose to 117...started chemo March 23.
PDH2024
in
Advanced Prostate Cancer
3 months ago
Dialysis or transplantation
Hallo everyone. I want to start form little story. According to my nephrologist I have CKD because of genetical legacy. And it seems to be true. My sister had a similar diagnosis. In her's 23 she went to PD. It was in middle 2000's, local dialysis treatment was not so developed as now. She needed
Hallo everyone. I want to start form little story. According to my nephrologist I have CKD because of genetical legacy. And it seems to be true. My sister had a similar diagnosis. In her's 23 she went to PD. It was in middle 2000's, local dialysis treatment was not so developed as now. She needed
TomMilds
in
Kidney Dialysis
3 months ago
Reiki
does anyone know if Reiki works on liver disease , especially for cirrhosis which I’ve been diagnosed with 😩? I have read Reiki does but was hoping to get it clarified. Does Crohn’s affect the liver too?? Thank you all.
does anyone know if Reiki works on liver disease , especially for cirrhosis which I’ve been diagnosed with 😩? I have read Reiki does but was hoping to get it clarified. Does Crohn’s affect the liver too?? Thank you all.
Maggie153
in
British Liver Trust
3 months ago
Getting head around what to expect
I like to have facts. In times of stress I think Facts are our friend. Better to be prepared, mentally, physically, financially, with support systems, etc.. so looking for any insights as to what I should expect and prepare my husband, myself and my kids/family for in the weeks and months, years ahead
I like to have facts. In times of stress I think Facts are our friend. Better to be prepared, mentally, physically, financially, with support systems, etc.. so looking for any insights as to what I should expect and prepare my husband, myself and my kids/family for in the weeks and months, years ahead
Melzer2169
in
Advanced Prostate Cancer
3 months ago
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