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after iADT and recurrence: SATURN trial
Upshot. Intense short term ADT and radiation therapy for "oligorecurrence" after iADT https://www.sciencedirect.com/science/article/abs/pii/S0302283824000587 The reason you have to like it is that it should not require new drug development and trials etc. I wonder if it would be applicable to oligorecurrence
Upshot. Intense short term ADT and radiation therapy for "oligorecurrence" after iADT https://www.sciencedirect.com/science/article/abs/pii/S0302283824000587 The reason you have to like it is that it should not require new drug development and trials etc. I wonder if it would be applicable to oligorecurrence
Derf4223
in
Advanced Prostate Cancer
3 months ago
How to convince a GP to prescribe estradiol patches?
I've been busy with ADT for almost 5 years and one of the most insidious SE has always been hot flushes. I find them quite debilitating as, when they hit (and that's often), I'm briefly incapable to concentrate/perform any task. After reading about some of you guys experiences with estradiol patches
I've been busy with ADT for almost 5 years and one of the most insidious SE has always been hot flushes. I find them quite debilitating as, when they hit (and that's often), I'm briefly incapable to concentrate/perform any task. After reading about some of you guys experiences with estradiol patches
R1166
in
Advanced Prostate Cancer
3 months ago
Constant uti's
Hello everyone Hope you are all as well as you can be . I think I just need a space to talk where people understand and offer valuable advice. I was diognosed with sle lupus and sjogrens in Dec 22 and was put on hydroxychloroquine plus drops /ointments for eyes artificial saliva ect ect. Since then
Hello everyone Hope you are all as well as you can be . I think I just need a space to talk where people understand and offer valuable advice. I was diognosed with sle lupus and sjogrens in Dec 22 and was put on hydroxychloroquine plus drops /ointments for eyes artificial saliva ect ect. Since then
Lucylou72
in
LUPUS UK
6 months ago
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does an rls friendly diuretic exist?
I have bad swollen legs which my GP thinks is caused by excess fluid It probably comes from a combination of my RLS medicines ( Pregabalin 250 mg and 2mg Neupro patch) plus a recent knee replacement operation. To get rid of this excess fluid my GP upped my normal 50mg Spironolactone dose to 75 mg.
I have bad swollen legs which my GP thinks is caused by excess fluid It probably comes from a combination of my RLS medicines ( Pregabalin 250 mg and 2mg Neupro patch) plus a recent knee replacement operation. To get rid of this excess fluid my GP upped my normal 50mg Spironolactone dose to 75 mg.
thorp
in
Restless Legs Syndrome
11 months ago
Chemo or no/not yet?
59 years old. Metastatic/high volume. PSA hit 366 before starting Abiraterone and Degarelix. Start Lupron next week. Negative on DNA test. Will see what PSA looks like next week after a month of ADT. My question chemo, no chemo or wait on chemo? Onco and Rad Onco both seemed to have a very soft attitude
59 years old. Metastatic/high volume. PSA hit 366 before starting Abiraterone and Degarelix. Start Lupron next week. Negative on DNA test. Will see what PSA looks like next week after a month of ADT. My question chemo, no chemo or wait on chemo? Onco and Rad Onco both seemed to have a very soft attitude
4tunate1
in
Advanced Prostate Cancer
3 months ago
Was there ever really a chance for a cure?
When I began the Stampede protocol 1 1/2 yrs ago, it was my understanding that two years of Zytiga/Prednisone and three years of Lupon with radiation to the pelvic area at the 7 mo - 1 yr mark gave a chance for a "cure" under my conditions (3+4 gleason, etc). Now, my non-medical view of things is convincing
When I began the Stampede protocol 1 1/2 yrs ago, it was my understanding that two years of Zytiga/Prednisone and three years of Lupon with radiation to the pelvic area at the 7 mo - 1 yr mark gave a chance for a "cure" under my conditions (3+4 gleason, etc). Now, my non-medical view of things is convincing
duxlubber
in
Advanced Prostate Cancer
3 months ago
Pirtobrutinib triple trial Cycle 7 update
Hi, ya'll! I'm now finishing up Cycle 8 of: [i]
Time-limited Triplet Combination of Pirtobrutinib, Venetoclax, and Obinutuzumab for Patients With Treatment-naïve Chronic Lymphocytic Leukemia (CLL) or Richter Transformation (RT)
[/i] at M.D. Anderson in Houston, TX. https://clinicaltrials.gov
Hi, ya'll! I'm now finishing up Cycle 8 of: [i]
Time-limited Triplet Combination of Pirtobrutinib, Venetoclax, and Obinutuzumab for Patients With Treatment-naïve Chronic Lymphocytic Leukemia (CLL) or Richter Transformation (RT)
[/i] at M.D. Anderson in Houston, TX. https://clinicaltrials.gov
SeymourB
in
CLL Support
9 months ago
Higher pulse than average
I’m quite fit but am feeling as though I’ve run a marathon - heart rate up and air hungry . I have UAT and take Armour Thyroid. I’ve reduced the dose from 1 grain am and pm to 1 am and 1/2 pm but it hasn’t made any difference. This has been happening for about two weeks now. I also take HRT, vitamin
I’m quite fit but am feeling as though I’ve run a marathon - heart rate up and air hungry . I have UAT and take Armour Thyroid. I’ve reduced the dose from 1 grain am and pm to 1 am and 1/2 pm but it hasn’t made any difference. This has been happening for about two weeks now. I also take HRT, vitamin
Karen-Eleanor
in
Thyroid UK
1 year ago
Brain Fog or Dimentia?
Hey warriors! So how do you know if you have brain fog or the beginning of dementia? Is it possible to blame ADT and Zytiga? My husband has been on Ellegaard for five years and Zytiga for 2 1/2. Years, he seems to have a lot of memory issues lately, and I fear it’s only getting worse Any thoughts or
Hey warriors! So how do you know if you have brain fog or the beginning of dementia? Is it possible to blame ADT and Zytiga? My husband has been on Ellegaard for five years and Zytiga for 2 1/2. Years, he seems to have a lot of memory issues lately, and I fear it’s only getting worse Any thoughts or
Keeper70
in
Advanced Prostate Cancer
3 months ago
Weighing the pros and possible risks of treatment holiday.
I am looking for reliable articles (not too scientific please). We will be discussing w oncologist this week and again with his clinical trial people next month. My husband's only treatment has been 1st & 2nd generation hormone therapy (Eligard & Darolutamide) for 20 months. He reached >.1 nadar
I am looking for reliable articles (not too scientific please). We will be discussing w oncologist this week and again with his clinical trial people next month. My husband's only treatment has been 1st & 2nd generation hormone therapy (Eligard & Darolutamide) for 20 months. He reached >.1 nadar
Decktime
in
Advanced Prostate Cancer
3 months ago
PSA on the way up again
I am getting a little concerned about a increase in my PSA, and not just the increase, but also the increase in the rate of increase. Short history. Diagnosed March 2021 by MRI and biopsy Gleason 4 + 3, Stage T3B, ISUP 3 ADT (Zoladex) started June 2021 EBRT 60Gy in 20 fractions December 2021 Last
I am getting a little concerned about a increase in my PSA, and not just the increase, but also the increase in the rate of increase. Short history. Diagnosed March 2021 by MRI and biopsy Gleason 4 + 3, Stage T3B, ISUP 3 ADT (Zoladex) started June 2021 EBRT 60Gy in 20 fractions December 2021 Last
ParrotY
in
Prostate Cancer Network
3 months ago
why docs don’t want to prescribe opioids for RLS….😔
With all the recent total panic by docs on not prescribing opioids, I thought I would just attach Andy Berkowski’s excellent piece on why we are often being refused opioids now and almost certainly in the future at least for sometime. You may well have read this article before Kakally Andy Berkowski
With all the recent total panic by docs on not prescribing opioids, I thought I would just attach Andy Berkowski’s excellent piece on why we are often being refused opioids now and almost certainly in the future at least for sometime. You may well have read this article before Kakally Andy Berkowski
Kakally
in
Restless Legs Syndrome
9 months ago
Dutasteride Monotherapy is effective for Newly Diagnosed PCa men not on ADT
This plot shows men that either don't have PCa (Group A) or newly diagnosed men with PCa by biopsy (Group B). Neither group is on ADT. Dutasteride monotherapy (0.5 mg/day) causes an average drop in PSA of about 50% in both Groups, and an average drop of about 20% in prostate volume. In one man, his
This plot shows men that either don't have PCa (Group A) or newly diagnosed men with PCa by biopsy (Group B). Neither group is on ADT. Dutasteride monotherapy (0.5 mg/day) causes an average drop in PSA of about 50% in both Groups, and an average drop of about 20% in prostate volume. In one man, his
janebob99
in
Prostate Cancer Network
3 months ago
Slow colonic transit
I have been diagnosed with slow colonic transit after having all the usual bowel investigations. I have been suffering suffering from chronic constipation for several years. I have been taking Prucalopride for almost a month but unfortunately it has made no difference. My consultant has recommended
I have been diagnosed with slow colonic transit after having all the usual bowel investigations. I have been suffering suffering from chronic constipation for several years. I have been taking Prucalopride for almost a month but unfortunately it has made no difference. My consultant has recommended
Riccar24
in
IBS Network
9 months ago
Trying to stay positive when I dont "get" it
This pelvic floor tightness came out of nowhere several weeks ago. I never ever knew this existed. Now Im in on baclofen/valium suppositories, HRT therapy 3x a week. I go for hrs where I have no pain and then the spasms and throbbing begins. Is there anyone else going thru a similar situation? Im scared
This pelvic floor tightness came out of nowhere several weeks ago. I never ever knew this existed. Now Im in on baclofen/valium suppositories, HRT therapy 3x a week. I go for hrs where I have no pain and then the spasms and throbbing begins. Is there anyone else going thru a similar situation? Im scared
QueenVic1952
in
Pelvic Pain Support Network
1 year ago
High PSA upon diagnosis, treatment , and outcome
Hello, Diagnosed 9 months ago with Gleason 7 unfavorable… 2 4+3 ,2 3+4, and 1 3+3 ..on one side only ..I guess my high PSA score made it unfavorable , PSA 18. As a result had aggressive tri modality treatment .. brachytherapy seeds, 15 linac radiation sessions, and 9 months o ADT ..just stopped
Hello, Diagnosed 9 months ago with Gleason 7 unfavorable… 2 4+3 ,2 3+4, and 1 3+3 ..on one side only ..I guess my high PSA score made it unfavorable , PSA 18. As a result had aggressive tri modality treatment .. brachytherapy seeds, 15 linac radiation sessions, and 9 months o ADT ..just stopped
Yokohama2023
in
Prostate Cancer Network
3 months ago
First MO visit
Prostectomy in 2017 and radiation in 2020 with no further treatment. PSMA test in November 2023 was negative with PSA of 0.14 at that time. My PSA has now increased to 0.34. I have my first visit with an MO in a couple weeks. Any suggestions or hints as to what to expect for treatments following
Prostectomy in 2017 and radiation in 2020 with no further treatment. PSMA test in November 2023 was negative with PSA of 0.14 at that time. My PSA has now increased to 0.34. I have my first visit with an MO in a couple weeks. Any suggestions or hints as to what to expect for treatments following
RedBird713
in
Advanced Prostate Cancer
3 months ago
My experience with mental health and First Episode Psychosis.
The way in which acute Psychosis can affect your life is so overwhelming that I thought I’d write a piece to spread awareness and combat the stigmatization that this symptom of mental health illness has in our society. I have had a few years of struggles with anxiety, panic attacks and depression,
The way in which acute Psychosis can affect your life is so overwhelming that I thought I’d write a piece to spread awareness and combat the stigmatization that this symptom of mental health illness has in our society. I have had a few years of struggles with anxiety, panic attacks and depression,
shawshankred
in
Anxiety and Depression Support
3 months ago
up date
hi I will try and not write to much The nerve pain in my leg, I wrote about months ago, was caused by my hip Now going to have a hip replacement, followed by knee replacement and maybe other hip I am having these done at my local hospital and will bridge with clexane if still on Warfarin I am also
hi I will try and not write to much The nerve pain in my leg, I wrote about months ago, was caused by my hip Now going to have a hip replacement, followed by knee replacement and maybe other hip I am having these done at my local hospital and will bridge with clexane if still on Warfarin I am also
daisyd
in
Hughes Syndrome APS Forum
11 months ago
NGS Test/Next-Generation Sequencing Important to have done.
Hello friends. I just wanted to make sure that if you are able to have this testing done, it is really important for your health and treatments that are given for your TYPE of BC. I was dx in 2016 and MBC in 2019. Ibrance and Fasoldex lated aobut 2 years. I was and still am ER/PR + and HER2low, but
Hello friends. I just wanted to make sure that if you are able to have this testing done, it is really important for your health and treatments that are given for your TYPE of BC. I was dx in 2016 and MBC in 2019. Ibrance and Fasoldex lated aobut 2 years. I was and still am ER/PR + and HER2low, but
Hopeful4Cure
in
SHARE Metastatic Breast Cancer
3 months ago
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