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Enzyme Replacement Therapy
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GnRH analogues
Hi all, I am due to be starting injectable GnRH analogues soon alongside a HRT, dose anyone have any advice/ guidance on them and their side effects and management? In the past I have had Nafarelin (Synarel). The plan is to have these before surgery as NHS wait is 50 weeks where I am. Thanks
Hi all, I am due to be starting injectable GnRH analogues soon alongside a HRT, dose anyone have any advice/ guidance on them and their side effects and management? In the past I have had Nafarelin (Synarel). The plan is to have these before surgery as NHS wait is 50 weeks where I am. Thanks
Foodman500
in
Endometriosis UK
9 months ago
Caffeic acid phenethyl ester (CAPE) is an ingredient in bee propolis. See below for invitro and mice evidence for inhibition AR-V7 by CAPE
Human studies needed. Caffeic acid phenethyl ester suppresses the expression of androgen receptor variant 7 via inhibition of CDK1 and AKT Ying-Yu Kuo, Chieh Huo, Chia-Yang Li & Chih-Pin Chuu Cancer Gene Therapy (2024) doi: 10.1038/s41417-024-00753-z Abstract Androgen receptor (AR) splice variant
Human studies needed. Caffeic acid phenethyl ester suppresses the expression of androgen receptor variant 7 via inhibition of CDK1 and AKT Ying-Yu Kuo, Chieh Huo, Chia-Yang Li & Chih-Pin Chuu Cancer Gene Therapy (2024) doi: 10.1038/s41417-024-00753-z Abstract Androgen receptor (AR) splice variant
Graham49
in
Advanced Prostate Cancer
30 days ago
I’m Coco & today Joolsg suggested I post re upcoming NHS Iron Infusion
Hello RLS people I’ve been here for a while reading & learning, getting the impression this is a very well informed serious & supportive community. You’ve helped me understand a lot…but am very aware there’s lots more to get my head around, so thanks for being here! now am about to have this IV
Hello RLS people I’ve been here for a while reading & learning, getting the impression this is a very well informed serious & supportive community. You’ve helped me understand a lot…but am very aware there’s lots more to get my head around, so thanks for being here! now am about to have this IV
Barnclown
in
Restless Legs Syndrome
1 month ago
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Adhd guidance
Hello everyone!! It has been 3 years since we started medication for my daughter who has adhd and we tried a lot of medications vyvanse, methylphenidate, guanfacine and the doctor was just increasing the dose but for her the first 2 weeks the medecine works and after that just stopped working. We went
Hello everyone!! It has been 3 years since we started medication for my daughter who has adhd and we tried a lot of medications vyvanse, methylphenidate, guanfacine and the doctor was just increasing the dose but for her the first 2 weeks the medecine works and after that just stopped working. We went
Purple008
in
CHADD's ADHD Parents Together
1 month ago
Not PCa related, but interesting new delivery techniques:
"It is a responsive therapy strategy towards the various cell states. This intelligent nanomachine with controlled release of anti-cancer drug in specific cancer cell subtypes can reduce the side effect to normal cells and facilitate the targeted therapy, which is promising as a theranostics nanoplatform
"It is a responsive therapy strategy towards the various cell states. This intelligent nanomachine with controlled release of anti-cancer drug in specific cancer cell subtypes can reduce the side effect to normal cells and facilitate the targeted therapy, which is promising as a theranostics nanoplatform
Maxone73
in
Advanced Prostate Cancer
1 month ago
EMG and NCT tests query
after over 2 years of waiting to be referred, i finally have an appt with neurophysology for EMG and NCT tests but they have booked the appt at 8.30 in the morning. thing is that the symptoms of awful burning/frozen sensation which iniatially were only in my right foot (started about 6 years ago at
after over 2 years of waiting to be referred, i finally have an appt with neurophysology for EMG and NCT tests but they have booked the appt at 8.30 in the morning. thing is that the symptoms of awful burning/frozen sensation which iniatially were only in my right foot (started about 6 years ago at
Crochet_fan
in
Neuropathy Support
1 month ago
Rhinitis Medicamentosa/A.F./Hip Replacement
Hi, I am about to have a consultation assessment for a hip replacement and having already posted about my concern with having to stop my Flecainide (150mg x 2) pre-op and being scared of going into A.F. prior or during the op. -my other big problem is having used Otrivine type nasal decongestant sprays
Hi, I am about to have a consultation assessment for a hip replacement and having already posted about my concern with having to stop my Flecainide (150mg x 2) pre-op and being scared of going into A.F. prior or during the op. -my other big problem is having used Otrivine type nasal decongestant sprays
Fib36
in
AF Association
6 months ago
Group Therapy #3
Got a group meeting today and i'm nervous because I feel that people can pick up on my body language and read into it and notice, i'm nervous. Also afraid that I wont be able to stop observing the people around me and what they're doing and that will be noticed as well. I'd like some advice please.
Got a group meeting today and i'm nervous because I feel that people can pick up on my body language and read into it and notice, i'm nervous. Also afraid that I wont be able to stop observing the people around me and what they're doing and that will be noticed as well. I'd like some advice please.
EricJones
in
Anxiety and Depression Support
1 month ago
Any successful treatment with red light therapy for peripheral neuropathy?
Hello, I am wondering whether or not it’s worth pursuing some sort of photobiomodulation (red light) therapy as a way of addressing idiopathic peripheral neuropathy which, in my case, means numb feet with burning soles at night. Has anybody had any success with these types of intervention, either through
Hello, I am wondering whether or not it’s worth pursuing some sort of photobiomodulation (red light) therapy as a way of addressing idiopathic peripheral neuropathy which, in my case, means numb feet with burning soles at night. Has anybody had any success with these types of intervention, either through
1jay
in
Neuropathy Support
1 month ago
Can people with hypothyroidism suffer with sweats and heat intolerance?
Before I was diagnosed with hypothyroidism and put on medication, I suffered with dreadful sweating for years; eating hot food or drinks would being it on as would housework and sitting in a stuffy office environment. This would be the type that would soak on hair and clothing. For a long time I thought
Before I was diagnosed with hypothyroidism and put on medication, I suffered with dreadful sweating for years; eating hot food or drinks would being it on as would housework and sitting in a stuffy office environment. This would be the type that would soak on hair and clothing. For a long time I thought
Upanddownlady15
in
Thyroid UK
9 months ago
t3 Monotherapy
Hello everyone, I have been a reader of the forum for a while now and it is nice to know so many other people are struggling with un-resolved thyroid problems. This forum was the first place where I thought wow, these guys get it. I have hypermobile ehlers danlos syndrome, I was diagnosed with MS
Hello everyone, I have been a reader of the forum for a while now and it is nice to know so many other people are struggling with un-resolved thyroid problems. This forum was the first place where I thought wow, these guys get it. I have hypermobile ehlers danlos syndrome, I was diagnosed with MS
Jimjamio
in
Thyroid UK
1 month ago
help with results please
I’d be grateful if anyone could help with results please. I’m on combined therapy 50mg T4 and 35mg T3 TFT 0.02 (0.35-4.94) FT3 4.5 (2.4-6.00) FT4 8.1 (9.00-19.00) B12 433 (187-883) Vit D 126.1 >50 Thank you :)
I’d be grateful if anyone could help with results please. I’m on combined therapy 50mg T4 and 35mg T3 TFT 0.02 (0.35-4.94) FT3 4.5 (2.4-6.00) FT4 8.1 (9.00-19.00) B12 433 (187-883) Vit D 126.1 >50 Thank you :)
Bollieforme
in
Thyroid UK
1 month ago
Any advice welcome on latest blood tests
I've been tinkering around with Hydrocortisone and thyroid replacement for over a year now and been symptomatic for almost 4 years with low tsh and frees. I recently stopped all thyroid and HC and felt awful after around a month, so asked my GP for help (big mistake). They only do email consults and
I've been tinkering around with Hydrocortisone and thyroid replacement for over a year now and been symptomatic for almost 4 years with low tsh and frees. I recently stopped all thyroid and HC and felt awful after around a month, so asked my GP for help (big mistake). They only do email consults and
Jamima
in
Thyroid UK
9 months ago
back again - people saying I have thyroid issues - I don’t know what to do?
people keep saying my mood etc could be thyroid related and weight gain. here are my trackers of thyroid… I’ll post the rest below this. I don’t know what to do as I think my HRT is doing this. GPs won’t listen. I have no relationship with them at all. What are your thoughts?
people keep saying my mood etc could be thyroid related and weight gain. here are my trackers of thyroid… I’ll post the rest below this. I don’t know what to do as I think my HRT is doing this. GPs won’t listen. I have no relationship with them at all. What are your thoughts?
Kath2022
in
Thyroid UK
9 months ago
Group Therapy #2
So i went to my second group therapy. It went well, know seemed to be paying much attention to my body language (like I'm afraid of) no one seemed to see me see them carrying on and being themselves. (hyper focusing on them). But the one thing I cant stop from happening is hearing background sounds such
So i went to my second group therapy. It went well, know seemed to be paying much attention to my body language (like I'm afraid of) no one seemed to see me see them carrying on and being themselves. (hyper focusing on them). But the one thing I cant stop from happening is hearing background sounds such
EricJones
in
Anxiety and Depression Support
1 month ago
Update on me
Before I go to visit Ralph this morning, thought I'd write a bit about me. I rang this morning to see how his first night was, he'd vomited a little which she said was due to the stress of the move, but then he was fine and slept well. Last night was the first decent sleep I've had since his operation
Before I go to visit Ralph this morning, thought I'd write a bit about me. I rang this morning to see how his first night was, he'd vomited a little which she said was due to the stress of the move, but then he was fine and slept well. Last night was the first decent sleep I've had since his operation
Castleview
in
British Heart Foundation
1 month ago
HRT patches
Hello 👋 beautiful family, can Evorel Conti patches cause stomach pain please? I will be happy if someone help me with the question thanks
Hello 👋 beautiful family, can Evorel Conti patches cause stomach pain please? I will be happy if someone help me with the question thanks
ceenana
in
Endometriosis UK
9 months ago
Tips for knee pain at 68
Hi everyone, I'm Lyndon. I Woke up Saturday morning with a horrible surprise - knee pain. It's centered on the front left side of my right knee, a dull ache that's been keeping me up at night and making it tough to move around. At 68, I've had my fair share of aches and pains, but this is new territory
Hi everyone, I'm Lyndon. I Woke up Saturday morning with a horrible surprise - knee pain. It's centered on the front left side of my right knee, a dull ache that's been keeping me up at night and making it tough to move around. At 68, I've had my fair share of aches and pains, but this is new territory
LyndonH
in
Pain Concern
1 month ago
When does it go?!
Hey everyone. Would really love some positive replies 🤞 My story so far…. I had hip replacement in Feb 22…by Oct 22 I could not get out of bed….had to roll off onto the floor and loosen those muscles for around an hour or so. Tired all the time, sore in the glutes, hip area, neck and shoulders
Hey everyone. Would really love some positive replies 🤞 My story so far…. I had hip replacement in Feb 22…by Oct 22 I could not get out of bed….had to roll off onto the floor and loosen those muscles for around an hour or so. Tired all the time, sore in the glutes, hip area, neck and shoulders
Poly1975
in
PMRGCAuk
6 months ago
Endo back after surgical menopause - anyone else?
It's a long story so I shall keep it short - I had TLH/BSO with excision at a BSGE centre in 2017, putting me in surgical meno. Things were generally OK for a while but about 18 months ago I started to get symptoms again (pain, cystitis, then the unpredictable guts started). Gave up on the wait for an
It's a long story so I shall keep it short - I had TLH/BSO with excision at a BSGE centre in 2017, putting me in surgical meno. Things were generally OK for a while but about 18 months ago I started to get symptoms again (pain, cystitis, then the unpredictable guts started). Gave up on the wait for an
Hidden
in
Endometriosis UK
9 months ago
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