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LATITUDE secondary analysis - Concurrent use of Abiraterone and NSAIDs - higher risk of Prostate Cancer Specific Mortality and inferior OS
https://doi.org/10.1200/JCO.2024.42.4_suppl.120 ”Conclusions: In this secondary analysis, concomitant exposure to 7 classes of medications was not associated with any statistically significant modification of abiraterone effect on OS in de novo high risk mHSPC. Men who received concurrent NSAIDs had
https://doi.org/10.1200/JCO.2024.42.4_suppl.120 ”Conclusions: In this secondary analysis, concomitant exposure to 7 classes of medications was not associated with any statistically significant modification of abiraterone effect on OS in de novo high risk mHSPC. Men who received concurrent NSAIDs had
Graham49
in
Advanced Prostate Cancer
8 months ago
A line of reasoning?
morning gang.As my disease progresses I seem to have more allergy symptoms (itchy nose, roof of mouth, eyes etc). I looked this up in conjunction with Parkinson’s. Apparently people who get hay fever are more likely to get PD than those who don’t. They both stem from brain inflammation. So I thought
morning gang.As my disease progresses I seem to have more allergy symptoms (itchy nose, roof of mouth, eyes etc). I looked this up in conjunction with Parkinson’s. Apparently people who get hay fever are more likely to get PD than those who don’t. They both stem from brain inflammation. So I thought
jeeves19
in
Cure Parkinson's
8 months ago
too many meds?
is anyone else on a large cocktail of meds like me? I’m thinking I might be on too many and I am going to have a chat to my GP next week as Cardiology have discharged me I currently take nicirandil 20mgx2 Ramipril 5mg x2 Ranolazine 750mg x2 Isosorbide 60mg x2 Amlodipine 10mg Bisoprolol 10mg
is anyone else on a large cocktail of meds like me? I’m thinking I might be on too many and I am going to have a chat to my GP next week as Cardiology have discharged me I currently take nicirandil 20mgx2 Ramipril 5mg x2 Ranolazine 750mg x2 Isosorbide 60mg x2 Amlodipine 10mg Bisoprolol 10mg
Jenzhearts
in
British Heart Foundation
8 months ago
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Exercise with mitral regurgitation
Posting for my husband in his words as he doesn't do 'tech'.I am 66 , after two strokes I now have mitral valve regurgitation and a dilated left aorta. My consultant just gives me a list of results, no interpretation or discussion and treatment is to continue the medication, along with the healthy
Posting for my husband in his words as he doesn't do 'tech'.I am 66 , after two strokes I now have mitral valve regurgitation and a dilated left aorta. My consultant just gives me a list of results, no interpretation or discussion and treatment is to continue the medication, along with the healthy
BlueDragonfly60
in
British Heart Foundation
8 months ago
Pegasys Update 1.0
Finally getting around to sharing my experiences of starting Pegasys. First a little background. Diagnosed with ET JAK2+ in 2019 after a decade of scintillating scotomas with increasing frequency at almost weekly. Aspirin cut this to approx. 90 days! Over the next three years increasingly struggled with
Finally getting around to sharing my experiences of starting Pegasys. First a little background. Diagnosed with ET JAK2+ in 2019 after a decade of scintillating scotomas with increasing frequency at almost weekly. Aspirin cut this to approx. 90 days! Over the next three years increasingly struggled with
Crossefield
in
MPN Voice
8 months ago
Platelets
Hi, me again.Jak2 positive ET. On aspirin since 2018, and HU since 2019. Platelets this week are down to 366 and HCT risen to 0.503 Last review three months ago, platelets were 450. My query is, how safe is it to allow the platelets to drop? My next haem opa was thus week, but cancelled by them and
Hi, me again.Jak2 positive ET. On aspirin since 2018, and HU since 2019. Platelets this week are down to 366 and HCT risen to 0.503 Last review three months ago, platelets were 450. My query is, how safe is it to allow the platelets to drop? My next haem opa was thus week, but cancelled by them and
Mcrg
in
MPN Voice
8 months ago
Aspirin and ET
Hi. I have E T and I’ve been on hydroxy and aspirin for 4 years. Saw the haematologist last week. She said that my spleen was a little enlarged but nothing to worry about. I questioned the aspirin that might giving me problems and wondered why I couldn’t take apixaban instead . She said that it didn
Hi. I have E T and I’ve been on hydroxy and aspirin for 4 years. Saw the haematologist last week. She said that my spleen was a little enlarged but nothing to worry about. I questioned the aspirin that might giving me problems and wondered why I couldn’t take apixaban instead . She said that it didn
Cokopops
in
MPN Voice
8 months ago
Worries about side effects of hydroxycarbamide - hair loss in particular
I was diagnosed with ET last July aged 66. I also have type 1 diabetes though this is well controlled. My consultant recommended I start taking hydroxycarbamide but I have resisted so far as I'm concerned about the side effects (particularly hair loss!), though I take daily aspirin as prescribed. I
I was diagnosed with ET last July aged 66. I also have type 1 diabetes though this is well controlled. My consultant recommended I start taking hydroxycarbamide but I have resisted so far as I'm concerned about the side effects (particularly hair loss!), though I take daily aspirin as prescribed. I
gardner99
in
MPN Voice
8 months ago
Enteric-coated Aspirin, anyone?
My GP changed my prescription from dispersible to Enteric-coated Gastro-resistant Aspirin to try to deal with morning queasiness, but there's no instructions from him or the dispensing pharmacy on the best time to take these. As they are absorbed differently, has anyone got any experiences, e.g. before
My GP changed my prescription from dispersible to Enteric-coated Gastro-resistant Aspirin to try to deal with morning queasiness, but there's no instructions from him or the dispensing pharmacy on the best time to take these. As they are absorbed differently, has anyone got any experiences, e.g. before
STEMI_Dave
in
British Heart Foundation
8 months ago
Unsure of treatment
My first post. I was told that I had an MPN 6-7 years ago and that I had too many platelets. My haematologist has never given me any details about my disorder and I have just presumed it was ET . I was put on aspirin which eventually gave severe stomach problems. I have now been told to start hydroxyurea
My first post. I was told that I had an MPN 6-7 years ago and that I had too many platelets. My haematologist has never given me any details about my disorder and I have just presumed it was ET . I was put on aspirin which eventually gave severe stomach problems. I have now been told to start hydroxyurea
Debinuk
in
MPN Voice
8 months ago
Help!! Severe aortic valve regurgitation
Hi there, I am a 53 year old lady with severe aortic valve regurgitation. I had decided to have the resilia tissue valve as I did not want to be on long term medication/blood thinners and I bruise very easily and am rather accident prone. When I saw the surgeon he said I would need to take aspirin
Hi there, I am a 53 year old lady with severe aortic valve regurgitation. I had decided to have the resilia tissue valve as I did not want to be on long term medication/blood thinners and I bruise very easily and am rather accident prone. When I saw the surgeon he said I would need to take aspirin
DancingSalsaIsFun
in
British Heart Foundation
8 months ago
MPN and secondary cancer
Hi Everyone, Diagnosed ET Nov 2023, currently taking daily aspirin and Hydroxy 500mg. I also have Hashimoto’s. Recently discovered lump in my breast, now have referral to hospital for further investigation. Fingers crossed it is a benign cyst. Just wondering if anyone else has experienced secondary
Hi Everyone, Diagnosed ET Nov 2023, currently taking daily aspirin and Hydroxy 500mg. I also have Hashimoto’s. Recently discovered lump in my breast, now have referral to hospital for further investigation. Fingers crossed it is a benign cyst. Just wondering if anyone else has experienced secondary
Vladimir1
in
MPN Voice
8 months ago
ET, platelets and stroke risk
Hello all from another new member. I was diagnosed with ET three months ago and as I am high-risk (over 60, JAK-2 positive, another mutation and a couple of TIA episodes) I have been prescribed daily aspirin and weekly Peg-interferon. I seem to have responded well to the interferon, as my platelets
Hello all from another new member. I was diagnosed with ET three months ago and as I am high-risk (over 60, JAK-2 positive, another mutation and a couple of TIA episodes) I have been prescribed daily aspirin and weekly Peg-interferon. I seem to have responded well to the interferon, as my platelets
Ginevra
in
MPN Voice
8 months ago
Tinnitus
I was diagnosed PV with positive Jak2 in November, 2022. Hydroxy and low dose aspirin has seemed to work for me. Good blood tests, only mild fatigue. But past few months, I developed a ringing in my ears and decided to have a hearing exam (at the urging of my PCP). It turns out that I have a condition
I was diagnosed PV with positive Jak2 in November, 2022. Hydroxy and low dose aspirin has seemed to work for me. Good blood tests, only mild fatigue. But past few months, I developed a ringing in my ears and decided to have a hearing exam (at the urging of my PCP). It turns out that I have a condition
Yanks7
in
MPN Voice
8 months ago
watchman after care meds
hi, everyone. I’ve been reading different conflicting things about lifetime aspirin vs stopping after the 6 months after the watchman procedure. I was wondering what those who had one’s protocol is. And how did you do? Thanks so much. Considering this.
hi, everyone. I’ve been reading different conflicting things about lifetime aspirin vs stopping after the 6 months after the watchman procedure. I was wondering what those who had one’s protocol is. And how did you do? Thanks so much. Considering this.
Fblue
in
Atrial Fibrillation Support
8 months ago
Update: x-ray shock 😲
Just an update after my bood test shower hf.I am still waiting on the echo. I was to have a chest x-ray. I mentioned back pain so I got both done. Chest x-ray was fine. The back x-ray was late!! Mmm Turns out I have a blocked artery in my left hip. Along with the heart meds, I also now am given aspirin
Just an update after my bood test shower hf.I am still waiting on the echo. I was to have a chest x-ray. I mentioned back pain so I got both done. Chest x-ray was fine. The back x-ray was late!! Mmm Turns out I have a blocked artery in my left hip. Along with the heart meds, I also now am given aspirin
Kristi74
in
British Heart Foundation
8 months ago
Cholesterol targets are different if on medication?
I posted my recent cholesterol results a few weeks back and received some commee we ts about them being way better than “normal” My GP surgery sent them to me with a note to say they were “normal” without any context. my Serum cholesterol for example is 2.4 mmol/L , way below the normal target of
I posted my recent cholesterol results a few weeks back and received some commee we ts about them being way better than “normal” My GP surgery sent them to me with a note to say they were “normal” without any context. my Serum cholesterol for example is 2.4 mmol/L , way below the normal target of
DWizza
in
British Heart Foundation
8 months ago
Circulation
I have ET jak2-ve. I'm 53 and on aspirin with my platelets usually around 1300. The last 6/12 my circulation in my toes and fingers has been getting worse. My hands and feet get icy cold, blue, and sometimes even purple with a reduced capillary refill. My haematologist says this is nothing to do with
I have ET jak2-ve. I'm 53 and on aspirin with my platelets usually around 1300. The last 6/12 my circulation in my toes and fingers has been getting worse. My hands and feet get icy cold, blue, and sometimes even purple with a reduced capillary refill. My haematologist says this is nothing to do with
lynnieb
in
MPN Voice
8 months ago
increase of platelets
got my blood results back and my platelets are constantly increasing each time. I’m on aspirin daily. Anyone know what other action I can take to try reducing platelets.
got my blood results back and my platelets are constantly increasing each time. I’m on aspirin daily. Anyone know what other action I can take to try reducing platelets.
Chihuahua1505
in
MPN Voice
9 months ago
Bleeding gums
Does anyone else suffer bleeding ir swollen gums while taking heart meds ,I'm on bishopol,2.5 statin 80mg asprin 75mg lanzaprole 30mg allupromnol 300mg amloadpine 5mg 15 months after quad heart bypass Thanks for taking time to read this
Does anyone else suffer bleeding ir swollen gums while taking heart meds ,I'm on bishopol,2.5 statin 80mg asprin 75mg lanzaprole 30mg allupromnol 300mg amloadpine 5mg 15 months after quad heart bypass Thanks for taking time to read this
Charl70
in
British Heart Foundation
9 months ago
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