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Diamine oxidase
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What are the worst drugs for Parkinson’s disease patients?
Patients may not be aware that some common drugs used for conditions such as headache or gastrointestinal dysmotility may also block dopamine, and concomitantly worsen Parkinson’s disease, or alternatively result in parkinsonism. These drugs include Prochlorperazine (Compazine), Promethazine (Phenergan
Patients may not be aware that some common drugs used for conditions such as headache or gastrointestinal dysmotility may also block dopamine, and concomitantly worsen Parkinson’s disease, or alternatively result in parkinsonism. These drugs include Prochlorperazine (Compazine), Promethazine (Phenergan
Kia17
in
Cure Parkinson's
2 years ago
P2B001 Shows Good Efficacy, Safety With Early Parkinson’s in Phase 3 Trial (combination of ER pramipexole and rasagiline)
A Phase 3 clinical trial assessing P2B001 in people with early Parkinson’s disease met its primary and a key secondary goal, with the investigative therapy showing superior efficacy to either of its two components, the approved medicines pramipexole and rasagiline, its developer, Pharma Two B, announced
A Phase 3 clinical trial assessing P2B001 in people with early Parkinson’s disease met its primary and a key secondary goal, with the investigative therapy showing superior efficacy to either of its two components, the approved medicines pramipexole and rasagiline, its developer, Pharma Two B, announced
Hidden
in
Cure Parkinson's
2 years ago
Dopamine agonist withdrawal syndrome
I recently changed antidepressant medications from cipralex to trintellix . during the process I have experienced nausea vomiting, fatigue, anxiety, increased tremors and generally feeling unwell. I take sinemet three times a day and after my noon dose I get relief from these symptoms for up to four
I recently changed antidepressant medications from cipralex to trintellix . during the process I have experienced nausea vomiting, fatigue, anxiety, increased tremors and generally feeling unwell. I take sinemet three times a day and after my noon dose I get relief from these symptoms for up to four
Hidden
in
Cure Parkinson's
2 years ago
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A theory, perhaps a warning
the short version: Excessive intake of dopamine enhancing supplements may knock serotonin out of balance resulting in a severe episode of depression. The longer version: Here's what happened to me and my guess as to why/how - I was anticipating a need for a little extra help with my Parkinsons symptoms
the short version: Excessive intake of dopamine enhancing supplements may knock serotonin out of balance resulting in a severe episode of depression. The longer version: Here's what happened to me and my guess as to why/how - I was anticipating a need for a little extra help with my Parkinsons symptoms
bassofspades
in
Cure Parkinson's
2 years ago
The Loss of Friendships post Parkinsons Diagnosis
(I did not write this but have the same experiences.) There was a pivotal, yet somewhat inevitable crossroads juncture that I encountered in my Parkinson’s "journey." The culling of my social connections. The enormity of the juggernaut diagnosis that I encountered led to a rude awakening and forced
(I did not write this but have the same experiences.) There was a pivotal, yet somewhat inevitable crossroads juncture that I encountered in my Parkinson’s "journey." The culling of my social connections. The enormity of the juggernaut diagnosis that I encountered led to a rude awakening and forced
beehive23
in
Cure Parkinson's
2 years ago
Oral Molecule PD13R Safely Eases Dyskinesia Tied to Levodopa in Primate Model
A newly discovered oral molecule, called PD13R, significantly lessened levodopa-induced dyskinesia, its involuntary and jerky movements, while maintaining the therapy’s benefits in a non-human primate model of Parkinson’s disease. Notably, in contrast to Gocovri (amantadine) — an approved therapy to
A newly discovered oral molecule, called PD13R, significantly lessened levodopa-induced dyskinesia, its involuntary and jerky movements, while maintaining the therapy’s benefits in a non-human primate model of Parkinson’s disease. Notably, in contrast to Gocovri (amantadine) — an approved therapy to
Hidden
in
Cure Parkinson's
2 years ago
How do you fight game addiction?
I'm in my second year of university - I have a lot of assignments. I created a routine or system that I can manage my tasks, my daily stuff that needs to be done. In the first days, I follow that system so well. But in the following days, I often got stressed or something that causes me anxiety and I
I'm in my second year of university - I have a lot of assignments. I created a routine or system that I can manage my tasks, my daily stuff that needs to be done. In the first days, I follow that system so well. But in the following days, I often got stressed or something that causes me anxiety and I
raccoon_
in
CHADD's Adult ADHD Support
2 years ago
Online relationship (please don't judge)
Hi. This is really uncomfortable to talk about but it's eating me alive. It's really killing me. I can't do anything. I even started fainting. I talked to my therapist but she was silent. I take my meds. Okay so i better finally spill it. This year has been a nightmare for me. My whole life was a nightmare
Hi. This is really uncomfortable to talk about but it's eating me alive. It's really killing me. I can't do anything. I even started fainting. I talked to my therapist but she was silent. I take my meds. Okay so i better finally spill it. This year has been a nightmare for me. My whole life was a nightmare
Against_the_current
in
Anxiety and Depression Support
2 years ago
Vitamin B1 and B3 question
Hi, I am seeing all the posts about Vitamin B1 and Niacin. I currently take a dopamine agonist mirapexin and a MAOI Selegeline low dose plus vitamin E, CoenzymQ as prescribed by my neurologist. I also recently started taking vitamin D. Could someone advise how much B1 and B3 to try and what time of day
Hi, I am seeing all the posts about Vitamin B1 and Niacin. I currently take a dopamine agonist mirapexin and a MAOI Selegeline low dose plus vitamin E, CoenzymQ as prescribed by my neurologist. I also recently started taking vitamin D. Could someone advise how much B1 and B3 to try and what time of day
louise2Rookery
in
Cure Parkinson's
2 years ago
The results of the Phase 2 trial: Mevidalen improves motor symptoms
The results of the Phase 2 safety/efficacy, randomized, placebo-controlled trial of Mevidalen (selective PAM of dopamine D1 receptor) in Lewy Body Dementia; N = 344 randomly assigned (1:1:1:1) to daily doses of 10, 30, or 75 mg; Improves motor symptoms. "LY3154207 is a small-molecule, positive allosteric
The results of the Phase 2 safety/efficacy, randomized, placebo-controlled trial of Mevidalen (selective PAM of dopamine D1 receptor) in Lewy Body Dementia; N = 344 randomly assigned (1:1:1:1) to daily doses of 10, 30, or 75 mg; Improves motor symptoms. "LY3154207 is a small-molecule, positive allosteric
Hidden
in
Cure Parkinson's
2 years ago
Desire to view disturbing images
Hi community, I have a strange habit I've never divulged to anyone. Trigger Warning: mention of suicide and graphic material For reasons I do not understand, when I am feeling understimulated, I search for graphic and disturbing images and videos. These include car accidents, suicide, shootings
Hi community, I have a strange habit I've never divulged to anyone. Trigger Warning: mention of suicide and graphic material For reasons I do not understand, when I am feeling understimulated, I search for graphic and disturbing images and videos. These include car accidents, suicide, shootings
Daffodileyes
in
CHADD's Adult ADHD Support
2 years ago
Does Levodopa cause your brain to produce less of "its own" dopamine?
Does anyone know if there is research on this topic? Does taking C/L actually discourage the brain from producing its own dopamine because it's being fed dopamine from an external source? I just wondered if this question had ever been explored because the human body is lazy. For example, if you
Does anyone know if there is research on this topic? Does taking C/L actually discourage the brain from producing its own dopamine because it's being fed dopamine from an external source? I just wondered if this question had ever been explored because the human body is lazy. For example, if you
Discogs_discogs
in
Cure Parkinson's
2 years ago
Ecopipam and Dr. Ondo.
Can anyone spot the flaw in his reasoning? See last 6 paragraphs after his name in center. As far as I can tell Ecopipam’s closest cousin is cannabis, but that’s neither here nor there New Study Will Test Treatment for Augmentation The RLS Foundation Research Grant Program has awarded $37,000 to William
Can anyone spot the flaw in his reasoning? See last 6 paragraphs after his name in center. As far as I can tell Ecopipam’s closest cousin is cannabis, but that’s neither here nor there New Study Will Test Treatment for Augmentation The RLS Foundation Research Grant Program has awarded $37,000 to William
Hidden
in
Restless Legs Syndrome
2 years ago
Neuroscientist Andrew Huberman 'not a fan' of melatonin since it can reduce baseline dopamine production
https://youtu.be/QmOF0crdyRU?t=7520
https://youtu.be/QmOF0crdyRU?t=7520
Rhyothemis
in
Cure Parkinson's
2 years ago
Ellfindoe and LotteM please ....
Thank you to Ellfindoe for being patient and explaining so well. I hope you don’t mind, but I have taken what you have said and put it in my own words to try to ensure that I understand what you have said. Here goes ….. The latest model of RLS is that there is a series of factors which lead to RLS
Thank you to Ellfindoe for being patient and explaining so well. I hope you don’t mind, but I have taken what you have said and put it in my own words to try to ensure that I understand what you have said. Here goes ….. The latest model of RLS is that there is a series of factors which lead to RLS
67Waterman
in
Restless Legs Syndrome
2 years ago
Increasing Dopamine receptor density?
Found randomly on the net : "There is a very powerful way to upregulate your dopamine receptor density, among other things, and it involves abstaining from sexual behaviours of any kind. Particularly self-pleasure and pornography watching. Fasting is another way. Any prolonged reduction of dopamine release
Found randomly on the net : "There is a very powerful way to upregulate your dopamine receptor density, among other things, and it involves abstaining from sexual behaviours of any kind. Particularly self-pleasure and pornography watching. Fasting is another way. Any prolonged reduction of dopamine release
Xenos
in
Cure Parkinson's
2 years ago
Parkinson's is not all in your head: Frozen Shoulder
I saw this picture the other day while researching frozen shoulder. It really hit me that PD is always described as problems being caused by dopamine cells dying in your brain and the subsequent lack of dopamine affecting your body. If you look at this picture and see the difference between the normal
I saw this picture the other day while researching frozen shoulder. It really hit me that PD is always described as problems being caused by dopamine cells dying in your brain and the subsequent lack of dopamine affecting your body. If you look at this picture and see the difference between the normal
Bolt_Upright
in
Cure Parkinson's
2 years ago
Parkinson's Disease - Hydrogen & Dopamine discussion with Dr. Joerg Birkmeyer and Mark Kent 11/26/2021
Parkinson's Disease - Hydrogen & Dopamine discussion with Dr. Joerg Birkmeyer and Mark Kent 11/26/2021 - https://youtu.be/py20sLqHeFs We discuss the relationship between hydrogen gas, L-Dopa, Dopamine and and how hydrogen producing bacteria can be the root cause of Parkinson's Disease and potential new
Parkinson's Disease - Hydrogen & Dopamine discussion with Dr. Joerg Birkmeyer and Mark Kent 11/26/2021 - https://youtu.be/py20sLqHeFs We discuss the relationship between hydrogen gas, L-Dopa, Dopamine and and how hydrogen producing bacteria can be the root cause of Parkinson's Disease and potential new
Bolt_Upright
in
Cure Parkinson's
2 years ago
Clarification needed please Ellfindoe, Joolsg and others
I still struggle with the fact that RLS absolutely responds to Ropinirole, which is a dopamine-receptor agonist, but then we are told no to that, and are advised to take Gabapentin, which is an anticonvulsant medication. Stupid question but is that telling me that lack of dopamine causes the nerves
I still struggle with the fact that RLS absolutely responds to Ropinirole, which is a dopamine-receptor agonist, but then we are told no to that, and are advised to take Gabapentin, which is an anticonvulsant medication. Stupid question but is that telling me that lack of dopamine causes the nerves
67Waterman
in
Restless Legs Syndrome
2 years ago
The Ultimate Guide to Increasing Dopamine Naturally
Saw this link on FB. Seems like solid foundational advice: The Ultimate Guide to Increasing Dopamine Naturally https://www.vitamonk.com/blogs/health/natural-ways-to-boost-dopamine It's not geared towards PD. Lot's of reference links at the end.
Saw this link on FB. Seems like solid foundational advice: The Ultimate Guide to Increasing Dopamine Naturally https://www.vitamonk.com/blogs/health/natural-ways-to-boost-dopamine It's not geared towards PD. Lot's of reference links at the end.
Bolt_Upright
in
Cure Parkinson's
2 years ago
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