Dopamine precursors, AcCys-L-Dopa-Cys-amide (SuperDopa) & N-acetylcysteine+DopAmide (SuperDopAmide), as potential neuroprotective agents for slowing Parkinsons
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from Yissum
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Our Innovation
Novel L-Dopa small molecular weight derivatives (“SuperDopa” molecules – SD1, SD2) designed to protect dopaminergic neurons from cell death concomitantly with a slow-release replenishing of the missing dopamine in the PD brain
Preliminary Results
SuperDopa (SD1) is very effective in reversing the oxidative stress induced by auranofin, an organo-gold compound that inhibits thioredoxin-reductase activity and elevates ROS in the cell
Increasing concentration of SD1 inhibits p38MAPK and ERK1/2 activity acting through the reversal of auranofin oxidizing effects in human neuronal SH-SY5Y cells
SD1 can also cross the blood brain barrier (BBB) and protect cognitive impairment following injury
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