Dopamine precursors, AcCys-L-Dopa-Cys-amide (SuperDopa) & N-acetylcysteine+DopAmide (SuperDopAmide), as potential neuroprotective agents for slowing Parkinsons
nature.com/articles/s41419-...
twitter.com/ScienceofPD/sta...
from Yissum
yissum.co.il/technologies/p...
Our Innovation
Novel L-Dopa small molecular weight derivatives (“SuperDopa” molecules – SD1, SD2) designed to protect dopaminergic neurons from cell death concomitantly with a slow-release replenishing of the missing dopamine in the PD brain
Preliminary Results
SuperDopa (SD1) is very effective in reversing the oxidative stress induced by auranofin, an organo-gold compound that inhibits thioredoxin-reductase activity and elevates ROS in the cell
Increasing concentration of SD1 inhibits p38MAPK and ERK1/2 activity acting through the reversal of auranofin oxidizing effects in human neuronal SH-SY5Y cells
SD1 can also cross the blood brain barrier (BBB) and protect cognitive impairment following injury
Scratching your head for the origin of Parkinsons - is there a common link between Dandruff and PD ?
Ways various PD treatments deplete essential chemicals.
Why should not we increase L-Dopa bioavailability in the Brain
Harnessing Probiotics to Deliver Parkinson’s Disease Treatment
Somebody asked why I take Berberine. I figured it something good to share.
