dopamine precursors, SuperDopa and SuperDopAmid as potential neuroprotective agents for slowing Parkinsons

Dopamine precursors, AcCys-L-Dopa-Cys-amide (SuperDopa) & N-acetylcysteine+DopAmide (SuperDopAmide), as potential neuroprotective agents for slowing Parkinsons

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from Yissum

yissum.co.il/technologies/p...

Our Innovation

Novel L-Dopa small molecular weight derivatives (“SuperDopa” molecules – SD1, SD2) designed to protect dopaminergic neurons from cell death concomitantly with a slow-release replenishing of the missing dopamine in the PD brain

Preliminary Results

SuperDopa (SD1) is very effective in reversing the oxidative stress induced by auranofin, an organo-gold compound that inhibits thioredoxin-reductase activity and elevates ROS in the cell

Increasing concentration of SD1 inhibits p38MAPK and ERK1/2 activity acting through the reversal of auranofin oxidizing effects in human neuronal SH-SY5Y cells

SD1 can also cross the blood brain barrier (BBB) and protect cognitive impairment following injury

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More on this.

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I-Red Pharma: Novel treatment for diseases with new small and multi-property molecules (Superdopa and Superdopamide)

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Thank you for this excellent find!

[Sydney75]

Exciting info! I do not think this is readily available for PD patients other than NAC.