Dopaminergic deficit in amyotrophic later... - Cure Parkinson's

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Dopaminergic deficit in amyotrophic lateral sclerosis assessed with SPECT

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Similarities between (ALS) and Parkinson’s disease suggest possible common traits in their pathogenesis. The underlying pathological process is thought in both cases to begin before the appearance of clinical symptoms, and there are indications of a shared genetic susceptibility. A cocaine analogue that selectively binds to the dopamine transporter located on dopaminergic nerve terminals showed that striatal IPT binding was moderately but significantly reduced in the ALS group compared with controls. Studies have provided evidence for an involvement of the dopaminergic system in ALS. The purpose of this study was to investigate whether patients with ALS show presynaptic nigrostriatal dopaminergic deficits detectable by single photon emission computed tomography (SPECT). These data indicate that nigrostriatal dopaminergic neurons are subclinically affected in a subset of patients with sporadic ALS.

jnnp.bmj.com/content/65/2/263

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