I have not figured out the dose. Not sure if you just need phytic acid or phytic acid plus inositol.
I found these documents:
Inositol hexaphosphate modulates the behavior of macrophages through alteration of gene expression involved in pathways of pro- and anti-inflammatory responses, and resolution of inflammation pathways 2021 onlinelibrary.wiley.com/doi...
Neuroprotective effect of the natural iron chelator, phytic acid in a cell culture model of Parkinson's disease 2008 pubmed.ncbi.nlm.nih.gov/182...
Phytic Acid Protects against 6-Hydroxydopamine-Induced Dopaminergic Neuron Apoptosis in Normal and Iron Excess Conditions in a Cell Culture Model 2011 ncbi.nlm.nih.gov/labs/pmc/a...
Iron regulatory protein (IRP)-iron responsive element (IRE) signaling pathway in human neurodegenerative diseases 2017 molecularneurodegeneration....
Neuroprotection of inositol hexaphosphate and changes of mitochondrion mediated apoptotic pathway and α-synuclein aggregation in 6-OHDA induced parkinson's disease cell model pubmed.ncbi.nlm.nih.gov/267...
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Bolt_Upright
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Yes, a lot more. And phytic acid is friend not foe and I don’t have to soak (ruin) nuts!
? But it has calcium (too much calcium is yet another problem) How are you going to chelate iron? Prior to knowing I have “it” I ate spinach smoothies almost daily. This is one of the many well intentioned but ill advised choices I made
I have not landed anywhere on Inositol hexaphosphate yet. I already take Myo-Inositol (and plan on increasing it. My head is spinning with all the new things under consideration.
Bolt, May I ask which one you are taking. I want to start too. I wonder how your current protocol is going? I am going to make a daily checklist to help free my mind from trying to remember what when and on what day. I do set timers for my supplements.
And yours CC. I have made a list of supplements and am working out a grading method so I can separate theoretical benefits from "kind of" proven benefits. A confidence rating. So far I have just done Licorice Extract. Licorice Extract is a keeper.
Just bear in mind (from what I have read, at least) that while DGL (the safe licorice supplement) is an iron-chelator, it is also a selective estrogen receptor agonist. Although there is a theory that elevated estrogen fends off PD (ie. one of the hypotheses for why PD affects men doubly more than women), it also causes erectile dysfunction in men and can raise the breast cancer risk for women. The same thing can be said about other "natural" iron chelators, including the following supplements: alfalfa, milk thistle extra, green tea and turmeric. Alpha-Lipoic Acid also supposed to be an iron chelator, but I have not read anything about it causing elevated estrogen levels. I have not read that IP-6 elevates estrogen levels either, but I have not read everything. In any case, I believe I have also read that people who have low ferritin should not take any iron chelator or else it will even lower their ferritin further.
Wait, are you implying that too much spinach triggers PD? I am referring to your comment that eating spinach smoothies before you had PD was ill-advised.
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Mucuna Puriens or natural Dopamine and Grapefruit juice
