Inositol hexaphosphate: A natural iron chelator that may protect dopamine neurons

[Bolt_Upright]

I saw this video today: youtu.be/2XxfH-VRaB8(Not working as expected?)

I have not figured out the dose. Not sure if you just need phytic acid or phytic acid plus inositol.

I found these documents:

Inositol hexaphosphate modulates the behavior of macrophages through alteration of gene expression involved in pathways of pro- and anti-inflammatory responses, and resolution of inflammation pathways 2021 onlinelibrary.wiley.com/doi...

Phytic Acid: From Antinutritional to Multiple Protection Factor of Organic Systems 2016 ift.onlinelibrary.wiley.com...

Neuroprotective effect of the natural iron chelator, phytic acid in a cell culture model of Parkinson's disease 2008 pubmed.ncbi.nlm.nih.gov/182...

Phytic Acid Protects against 6-Hydroxydopamine-Induced Dopaminergic Neuron Apoptosis in Normal and Iron Excess Conditions in a Cell Culture Model 2011 ncbi.nlm.nih.gov/labs/pmc/a...

Iron regulatory protein (IRP)-iron responsive element (IRE) signaling pathway in human neurodegenerative diseases 2017 molecularneurodegeneration....

Neuroprotection of inositol hexaphosphate and changes of mitochondrion mediated apoptotic pathway and α-synuclein aggregation in 6-OHDA induced parkinson's disease cell model pubmed.ncbi.nlm.nih.gov/267...

[Hidden]

Maybe this?

Iron chelation

[Bolt_Upright in reply to Hidden]

Interesting but not phytic acid:

Proprietary Enzyme/EDTA Blend 675 mg *

Providing the following active enzymes:

Polysaccharide Specific Enzymes

Glucoamylase (with isomaltase side chain activity) *

Chitosanase *

Cellulase *

Hemicellulase/Pectinase Complex *

Beta-Glucanase *

Protein and Peptide Specific Enzymes

Protease/Peptidase Complex with endopeptidase, exopeptidase, and DPP-IV activity *

Other Enzymes and EDTA

Lysozyme (from egg white) *

Serratia peptidase (enteric-coated)‡ *

EDTA (as disodium EDTA) *

[Hidden in reply to Bolt_Upright]

Yes, it’s not physic acid. I’m showing you another iron chelator you might want to consider.

I’ve been looking in to iron chelation as well. And calcium in the brain is another issue and of course glutamate.

EDTA

Iron chelator

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ncbi.nlm.nih.gov/labs/pmc/a...

[Bolt_Upright in reply to Hidden]

According to the video (and some of the links), Inositol hexaphosphate does more than Iron Chelation.

[Hidden in reply to Bolt_Upright]

Yes, a lot more. And phytic acid is friend not foe and I don’t have to soak (ruin) nuts!

[Hidden]

? But it has calcium (too much calcium is yet another problem) How are you going to chelate iron? Prior to knowing I have “it” I ate spinach smoothies almost daily. This is one of the many well intentioned but ill advised choices I made

Inositol

[Bolt_Upright in reply to Hidden]

I have not landed anywhere on Inositol hexaphosphate yet. I already take Myo-Inositol (and plan on increasing it. My head is spinning with all the new things under consideration.

[Hidden in reply to Bolt_Upright]

I’m trying to understand the difference if they are interchangeable

[Bolt_Upright in reply to Hidden]

Myo-inositol and Inositol hexaphosphate are different. Both seem to be helpful.

[Hidden in reply to Bolt_Upright]

Bolt, May I ask which one you are taking. I want to start too. I wonder how your current protocol is going? I am going to make a daily checklist to help free my mind from trying to remember what when and on what day. I do set timers for my supplements.

[Bolt_Upright in reply to Hidden]

Apologies CC. I still have not landed on this one. I am still trying to cut my stack. Still reviewing.

[Hidden in reply to Bolt_Upright]

I’m so grateful for all your work Bolt. 🌷

[Bolt_Upright in reply to Hidden]

And yours CC. I have made a list of supplements and am working out a grading method so I can separate theoretical benefits from "kind of" proven benefits. A confidence rating. So far I have just done Licorice Extract. Licorice Extract is a keeper.

[Hidden in reply to Bolt_Upright]

I’m essentially doing the same. I’m stuck on niacin in all its forms. I’m glad to hear licorice is a keeper!

[Discogs_discogs in reply to Hidden]

Just bear in mind (from what I have read, at least) that while DGL (the safe licorice supplement) is an iron-chelator, it is also a selective estrogen receptor agonist. Although there is a theory that elevated estrogen fends off PD (ie. one of the hypotheses for why PD affects men doubly more than women), it also causes erectile dysfunction in men and can raise the breast cancer risk for women. The same thing can be said about other "natural" iron chelators, including the following supplements: alfalfa, milk thistle extra, green tea and turmeric. Alpha-Lipoic Acid also supposed to be an iron chelator, but I have not read anything about it causing elevated estrogen levels. I have not read that IP-6 elevates estrogen levels either, but I have not read everything. In any case, I believe I have also read that people who have low ferritin should not take any iron chelator or else it will even lower their ferritin further.

[Bolt_Upright in reply to Discogs_discogs]

I can't find anything on DGL being an iron chelator. Do you have a link please?

[Discogs_discogs in reply to Bolt_Upright]

I stand corrected. I'm looking now and see nothing. Sorry, I don't know/recall where I got that from.

[Discogs_discogs in reply to Hidden]

Wait, are you implying that too much spinach triggers PD? I am referring to your comment that eating spinach smoothies before you had PD was ill-advised.

[Bolt_Upright]

Estimated Phytate Intake Is Associated with Improved Cognitive Function in the Elderly, NHANES 2013–2014 2021 mdpi.com/2076-3921/10/7/110...