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Diamine oxidase
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Nausea and pramipexole
Thanks to those who answered my cry for help getting off Pramipexole. Did anyone else who went into augmentation on that drug get severe nausea, vomiting, diarrhea, staggering, sweats, severe headache? l think I already said 600 mg gabapentin over 12 months gave me fits of anger, outbursts of inappropriate
Thanks to those who answered my cry for help getting off Pramipexole. Did anyone else who went into augmentation on that drug get severe nausea, vomiting, diarrhea, staggering, sweats, severe headache? l think I already said 600 mg gabapentin over 12 months gave me fits of anger, outbursts of inappropriate
Hidden
in
Restless Legs Syndrome
2 years ago
Starting medication
Hi all, I’m looking for advice on medication. I’m a 58 yo male. Non smoker, given up alcohol and caffeine (almost). Not on any meds or herbals Parents, Gparents and sister all have or had RLS. PLM stopping me get to sleep and leg movements continue when I am asleep. Legs often ache on a morning
Hi all, I’m looking for advice on medication. I’m a 58 yo male. Non smoker, given up alcohol and caffeine (almost). Not on any meds or herbals Parents, Gparents and sister all have or had RLS. PLM stopping me get to sleep and leg movements continue when I am asleep. Legs often ache on a morning
TDan
in
Restless Legs Syndrome
2 years ago
Teaching money habits
My 12 year old was diagnosed with ADHD hyperactivity last year and he’s on methylphenidate during the school day. He is really organized and gets straight A’s in school but struggles with math. His main struggles are impulsivity and constantly being on the go. He talks a lot, moves a lot, eats a lot
My 12 year old was diagnosed with ADHD hyperactivity last year and he’s on methylphenidate during the school day. He is really organized and gets straight A’s in school but struggles with math. His main struggles are impulsivity and constantly being on the go. He talks a lot, moves a lot, eats a lot
Bunny5689
in
CHADD's ADHD Parents Together
2 years ago
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New to ropinirole
My first time at a new neurologist. He started me on ropinirole 0.25mg 1/day at 7pm. I take 600mg gabapentin at 5pm and 9pm. He convinced me that I don't have CMT but have RLS. My feet are rather numb, and my ankles and shins hurt occasionally. I believe this is peripheral neuropathy, but he did not
My first time at a new neurologist. He started me on ropinirole 0.25mg 1/day at 7pm. I take 600mg gabapentin at 5pm and 9pm. He convinced me that I don't have CMT but have RLS. My feet are rather numb, and my ankles and shins hurt occasionally. I believe this is peripheral neuropathy, but he did not
fishinphil1946
in
Restless Legs Syndrome
2 years ago
A question about ashwagandha?
I was looking up this herb for interactions on the pharmacuetical database I subscribe to and read the following. I am concerned about any herb that could suppress dopamine, does the statement below mean that dopamine is also reduced which is not good effect for PD? I know many folks with and without
I was looking up this herb for interactions on the pharmacuetical database I subscribe to and read the following. I am concerned about any herb that could suppress dopamine, does the statement below mean that dopamine is also reduced which is not good effect for PD? I know many folks with and without
Sydney75
in
Cure Parkinson's
2 years ago
Role of the adrenals in my tremor and dopamine deficiency
I am wondering if I am alone in being aware of the connection between my adrenals and my dopamine deficiency and resulting tremors. I’d appreciate all feedback, whether academic or incidental. Firstly, I definitely have a dopamine deficiency because my dexterity can return to perfect for the small windows
I am wondering if I am alone in being aware of the connection between my adrenals and my dopamine deficiency and resulting tremors. I’d appreciate all feedback, whether academic or incidental. Firstly, I definitely have a dopamine deficiency because my dexterity can return to perfect for the small windows
Meg024
in
Cure Parkinson's
2 years ago
Methadone RLS RESULTS
hello, i was curious I have refractory rls and even buphenorphine and Methadone don’t do much it’s so strange my body hates me lol Has anyone taken opiates and had them not to much for u? it’s so weird how some people it saves their life some people can’t handle side effects and others it does nothing
hello, i was curious I have refractory rls and even buphenorphine and Methadone don’t do much it’s so strange my body hates me lol Has anyone taken opiates and had them not to much for u? it’s so weird how some people it saves their life some people can’t handle side effects and others it does nothing
RC723
in
Restless Legs Syndrome
2 years ago
Anyone want to share their story about going undiagnosed with ADHD until adulthood?
I'm in my 30s and was just diagnosed a couple months ago. I was going through a tough time a while back and I didn't know what was wrong. I was craving sugar like a fiend and completely lost my appetite. I spent days googling what may be the problem. I randomly stumbled across an article about how the
I'm in my 30s and was just diagnosed a couple months ago. I was going through a tough time a while back and I didn't know what was wrong. I was craving sugar like a fiend and completely lost my appetite. I spent days googling what may be the problem. I randomly stumbled across an article about how the
Sunshinegrl25
in
CHADD's Adult ADHD Support
2 years ago
ADHD career advice
After working in property management for 15 years I decided to quit and become a stay at home mom. I felt overwhelmed trying to run a house, kids,marriage, and career so I quit my job. Now at home I am restless so I started taking college classes to help with the lack of dopamine. However I'm not
After working in property management for 15 years I decided to quit and become a stay at home mom. I felt overwhelmed trying to run a house, kids,marriage, and career so I quit my job. Now at home I am restless so I started taking college classes to help with the lack of dopamine. However I'm not
Khyson2019
in
CHADD's Adult ADHD Support
2 years ago
Pioneering stem-cell trials in Japan report promising early results
Professor Jun Takahashi is involved in one trial expected to report results soon, in which researchers used donor-derived iPS cells to generate neurons that produce dopamine. They implanted these into the brains of seven people with Parkinson’s disease between 2018 and 2021. Takahashi says that no severe
Professor Jun Takahashi is involved in one trial expected to report results soon, in which researchers used donor-derived iPS cells to generate neurons that produce dopamine. They implanted these into the brains of seven people with Parkinson’s disease between 2018 and 2021. Takahashi says that no severe
Farooqji
in
Cure Parkinson's
2 years ago
Dividing the dose
There was a talk about dopamine levels and tolerance. How to avoid this by intermittent dosing. How the brain responds more strongly to surprise levels of dopamine. I've been trying this by dividing the dose of 3 madopar every 4 hours into 2s and 1s. And sometimes taking 2nd dose early before 1st
There was a talk about dopamine levels and tolerance. How to avoid this by intermittent dosing. How the brain responds more strongly to surprise levels of dopamine. I've been trying this by dividing the dose of 3 madopar every 4 hours into 2s and 1s. And sometimes taking 2nd dose early before 1st
Johnmo
in
Cure Parkinson's
2 years ago
dopamine
https://healthunlocked.com/cure-parkinsons/posts/write
https://healthunlocked.com/cure-parkinsons/posts/write
kaypeeoh
in
Cure Parkinson's
2 years ago
Recent preprint by Jeff Kordower et al. suggests tau (not alpha-syn) is the initial pathology in nigrostriatal dopamine neuron degeneration
"These data should change our thinking of PD pathology and therapies directed towards reducing pathological tau might be a better strategy than those directed at α-syn." Research paper preprint (not yet peer-reviewed): Is Tau the Initial Pathology in Dopaminergic Nigrostriatal Degeneration? Studies
"These data should change our thinking of PD pathology and therapies directed towards reducing pathological tau might be a better strategy than those directed at α-syn." Research paper preprint (not yet peer-reviewed): Is Tau the Initial Pathology in Dopaminergic Nigrostriatal Degeneration? Studies
jeffreyn
in
Cure Parkinson's
2 years ago
Depression
I wrote the following in response to a member on this sight and thought I would share with everyone. "I am taking the very small amount of Bupropian. I was prescribed 300mg daily but if I go over 12 mg the anxiety and headaches are unbearable. I was on prozac for 25 years. For me it was calming and
I wrote the following in response to a member on this sight and thought I would share with everyone. "I am taking the very small amount of Bupropian. I was prescribed 300mg daily but if I go over 12 mg the anxiety and headaches are unbearable. I was on prozac for 25 years. For me it was calming and
Birdland
in
Restless Legs Syndrome
2 years ago
B12-supplement causing restlessness, brain fog, anhedonia and sexual dysfunction
Hi! I made a post a while ago about reaction to B12. I still keep reacting badly. I dont understand what is happening and How.I keep getting restless and have bad sleep. Also get bad brain fog, concentration and anhedonia. The new symtom is sexual dysfunction.I had taken small doses B12 because of
Hi! I made a post a while ago about reaction to B12. I still keep reacting badly. I dont understand what is happening and How.I keep getting restless and have bad sleep. Also get bad brain fog, concentration and anhedonia. The new symtom is sexual dysfunction.I had taken small doses B12 because of
Sofa00
in
Pernicious Anaemia Society
2 years ago
Creativity as therapy?
This is a question from a forum newbie, I wonder if any others have found arts and crafts can help with RLS. I've had RLS for many years, Ropinirole lets me sleep (been taking for years; lucky, no augmentation yet) but is no help during the day. I find if I do painting, drawing, mosaic, sewing... even
This is a question from a forum newbie, I wonder if any others have found arts and crafts can help with RLS. I've had RLS for many years, Ropinirole lets me sleep (been taking for years; lucky, no augmentation yet) but is no help during the day. I find if I do painting, drawing, mosaic, sewing... even
Ouchagain
in
Restless Legs Syndrome
2 years ago
what else is deficient in PD? Norepinephrine?
should PD patients be supplementing other chemicals, neurotransmitters such as norepinephrine (NE) as well as dopamine? How would one supplement NE?
should PD patients be supplementing other chemicals, neurotransmitters such as norepinephrine (NE) as well as dopamine? How would one supplement NE?
Usufruct
in
Cure Parkinson's
2 years ago
If you're suffering from RLS, ead this. I suffered for 20 yrs before finding a solution.
I've dealt with symptoms of RLS for 20yrs & it's the worst torture I've ever endured. I got tired of masking my symptoms and never finding the underlying cause or a cure. After years or research I came across an article that gave me all the answers I'd been seeking and my life hasnt been the same.
I've dealt with symptoms of RLS for 20yrs & it's the worst torture I've ever endured. I got tired of masking my symptoms and never finding the underlying cause or a cure. After years or research I came across an article that gave me all the answers I'd been seeking and my life hasnt been the same.
Caruso1us
in
Restless Legs Syndrome
2 years ago
ECOPIPAM for AugmentationUPDATE
Some of you may remember that small trials of Ecopipam, a D1 antagonist were carried out by William Ondo inTexas in 2019 and showed encouraging initial results in treating Augmentation on Dopamine Agonists. https://www.tandfonline.com/doi/full/10.1080/00207454.2020.1838515 Dr Stefan Clements at
Some of you may remember that small trials of Ecopipam, a D1 antagonist were carried out by William Ondo inTexas in 2019 and showed encouraging initial results in treating Augmentation on Dopamine Agonists. https://www.tandfonline.com/doi/full/10.1080/00207454.2020.1838515 Dr Stefan Clements at
Joolsg
in
Restless Legs Syndrome
2 years ago
Cerebral dopamine neurotrophic factor protects and repairs dopamine neurons by novel mechanism
Since ER stress is thought to be one of the pathophysiological mechanisms contributing to the dopaminergic degeneration in PD, CDNF, and its small-molecule derivatives that are under development may provide useful tools for experimental medicine and future therapies for the treatment of PD and other
Since ER stress is thought to be one of the pathophysiological mechanisms contributing to the dopaminergic degeneration in PD, CDNF, and its small-molecule derivatives that are under development may provide useful tools for experimental medicine and future therapies for the treatment of PD and other
House2
in
Cure Parkinson's
2 years ago
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