There was a talk about dopamine levels and tolerance. How to avoid this by intermittent dosing. How the brain responds more strongly to surprise levels of dopamine. I've been trying this by dividing the dose of 3 madopar every 4 hours into 2s and 1s. And sometimes taking 2nd dose early before 1st catastrophically wears off.
I didn't finish listening and now can't find it. Does anyone know the link.
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Been trying something similar with Madopar. I take a 125mg capsule first thing to get over the therapeutic hump, then take a 62.5mg cap say two hours later to try and maintain the effective level. It sort of works, but often I feel it’s not quite enough and taking breakfast can defeat the process. I’ve also experimented by alternating the doses and this can work quite well but you have to find the ideal dosing interval.
What I haven’t done is try 6 half doses instead of 3 full ones but might give it a go.
One the members here, JohntPM, has come up with the attached to track likely changes to blood plasma of different drugs and different doses across the day. Have a play.
originalText
Hello,
That’s interesting. I would be keen to try it. I couldnt see the attachment?
Thanks
Only difficulty is avoiding protein if dividing it into too many doses.
Link here: parkinsonsmeasurement.org/t...
My theory:
If you function fairly well first thing in the morning before the first dose it probably means you are still producing of your own overnight if you haven’t taken any in the night. I think that means you will need less in the evening and more later in the morning as the natural cycle has a high point at midnight and low point at midday.
As you take each subsequent dose in the day the remains of the tail of the previous one underlies lies it so blood levels climb with each subsequent dose so you can feel worse in the evenings.
Taking some natural mucuna pruriens which has a peak of slightly different shape you can smoothe it out a bit too.
LAJ Nice visual picture, I think its going to be very useful
I’m not the words best artist 😅
Here’s one of schizophrenia and dopamine. I think the pushing the dose over the limit explains a lot of the overdosing symptoms lots of people are experiencing and overlaps with some of the symptoms of schizophrenia.
I tried to put link but it keeps removing it. To find it search “natural dopamine cycle schizophrenia”
Mannitol and Dopamine Levels
Niacin and Butyrate: Nutraceuticals Targeting Dysbiosis and Intestinal Permeability in Parkinson’s Disease
Thiamine and Dr Costantini, what we know and don't know
MRI with low dose radiation?
The Rational for High Dose Thiamine
