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Update on failing Calquence - Pirtobrutinib is Next
I spoke with my specialist from Upenn today and she wants to switch me to pirtobrutinib once it receives FDA approval for CLL in a few weeks. My questions are for those in clinical trials for pirtobrutinib. Any feedback is much appreciated as this will be my 5th treatment regimen and I’m a little
I spoke with my specialist from Upenn today and she wants to switch me to pirtobrutinib once it receives FDA approval for CLL in a few weeks. My questions are for those in clinical trials for pirtobrutinib. Any feedback is much appreciated as this will be my 5th treatment regimen and I’m a little
ReneeSusan
in
CLL America Support
1 year ago
hayfever medicstion
Hi there I need advice on hayfever med as I have open angle glaucoma . I’m allergic to blossom trees anc this usually starts end of feb I use to use Beconase but this is a steroid so a def no. I tried natural allergy inhalers last year but they don’t work. I need to take an oral med . Anybody who uses
Hi there I need advice on hayfever med as I have open angle glaucoma . I’m allergic to blossom trees anc this usually starts end of feb I use to use Beconase but this is a steroid so a def no. I tried natural allergy inhalers last year but they don’t work. I need to take an oral med . Anybody who uses
Salford49
in
Glaucoma UK
2 years ago
Depression
I have been feeling sad and bouts of crying. I’m in therapy and taking medication. Looking for support groups
I have been feeling sad and bouts of crying. I’m in therapy and taking medication. Looking for support groups
Musicpainting101
in
Anxiety and Depression Support
1 year ago
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Possible Uveitis
Hello all - I'd welcome your input regarding possible Uveitis. As you'll see from my profile, I have a diagnosis of lupus. My main problems are fatigue and brain fog, joint pain, generalised aches and pains, raynauds, mouth ulcers, and recurring anaemia. I have always had dry eyes. About a week ago
Hello all - I'd welcome your input regarding possible Uveitis. As you'll see from my profile, I have a diagnosis of lupus. My main problems are fatigue and brain fog, joint pain, generalised aches and pains, raynauds, mouth ulcers, and recurring anaemia. I have always had dry eyes. About a week ago
Ophelia1
in
LUPUS UK
2 years ago
Visual field deterioration 6 weeks after cataract and Hydrus stent surgery?
I think that the sight loss area below my right eye has got worse between 31 Dec and now , 15 Jan. Had surgery 1 Dec. Has anyone else experienced this? Background : I was diagnosed with normal tension open angle glaucoma in July this year. My visual fields got worse between August and November, and
I think that the sight loss area below my right eye has got worse between 31 Dec and now , 15 Jan. Had surgery 1 Dec. Has anyone else experienced this? Background : I was diagnosed with normal tension open angle glaucoma in July this year. My visual fields got worse between August and November, and
Iona57
in
Glaucoma UK
2 years ago
Sertraline and Pregabalin
Background story Hello, some of you might remember a while ago I was asking a few questions about pregabalin, which I did take for a short while. For a series of reasons, I stopped taking that when my GP suggested increasing the dose ( I won't go into details now). As my RLS is a bother, I discussed
Background story Hello, some of you might remember a while ago I was asking a few questions about pregabalin, which I did take for a short while. For a series of reasons, I stopped taking that when my GP suggested increasing the dose ( I won't go into details now). As my RLS is a bother, I discussed
Figar
in
Restless Legs Syndrome
1 year ago
Abiraterone vs Docetaxel
In the CHAARTED trial, metastatic burden was divided into low burden (4 lesions). CHAARTED’s criteria seems to have become the standard for evaluating how metastatic burden affects choices of treatment and outcome. I bring up the metastatic burden, because I could not find a clinical trial where ADT
In the CHAARTED trial, metastatic burden was divided into low burden (4 lesions). CHAARTED’s criteria seems to have become the standard for evaluating how metastatic burden affects choices of treatment and outcome. I bring up the metastatic burden, because I could not find a clinical trial where ADT
TMcgee
in
Advanced Prostate Cancer
1 year ago
Cancelled cycle
Hi everyone, just wanted to see if anyone had experienced a cycle cancellation due to the risk of OHSS. After 8 days of stimulation, I've been told that my cycle had to be cancelled as too many follicles have been developing (29 were seen on the scan) and my estrogen levels were way too high (3,500
Hi everyone, just wanted to see if anyone had experienced a cycle cancellation due to the risk of OHSS. After 8 days of stimulation, I've been told that my cycle had to be cancelled as too many follicles have been developing (29 were seen on the scan) and my estrogen levels were way too high (3,500
Gold00
in
Fertility Network UK
1 year ago
Help! Depression interrupted my parenting.. I am so so sad.
I have a particular problem these last few years well 6 years now. I raised my daughter as a single mother for 14 years I did a very good job I gave my daughter a lot of the things that my parents weren't able to provide for me emotionally. I know I did a really good job.. considering my parents were
I have a particular problem these last few years well 6 years now. I raised my daughter as a single mother for 14 years I did a very good job I gave my daughter a lot of the things that my parents weren't able to provide for me emotionally. I know I did a really good job.. considering my parents were
Montana136
in
Anxiety and Depression Support
1 year ago
embarrassed, and depressed
I was feeling depressed/lonely. I went on Facebook dating. And I responded to someone 11 years younger than me and he works for the military. I was in the military, so I thought we’d have common interest. Anyway, He text me why are you so nice one moment and so mean the next, and he said my name. I
I was feeling depressed/lonely. I went on Facebook dating. And I responded to someone 11 years younger than me and he works for the military. I was in the military, so I thought we’d have common interest. Anyway, He text me why are you so nice one moment and so mean the next, and he said my name. I
ElephantsHear
in
Anxiety and Depression Support
1 year ago
Targeting Glutamine Metabolism
New paper below [1a]. Full text: [1b]. First, a few notes. "Studies have indicated the importance of glutamine in certain tumors. For example, the inhibition of glutamine metabolism was reported to prevent growth of several tumors such as breast, liver, kidney and T-cell lymphoblastic leukemia." Wiki
New paper below [1a]. Full text: [1b]. First, a few notes. "Studies have indicated the importance of glutamine in certain tumors. For example, the inhibition of glutamine metabolism was reported to prevent growth of several tumors such as breast, liver, kidney and T-cell lymphoblastic leukemia." Wiki
pjoshea13
in
Fight Prostate Cancer
1 year ago
Relapse with blurred vison
Hi all All was going pretty well, managed to taper from 80 mg to 6 mg after almost 2 years (in april) after initial blurred vision/AF. Have not had any serious side affects or major relapses, one incident with raised CRP/ESR while tapering at 40 but markers settled. Then out of the blue today had
Hi all All was going pretty well, managed to taper from 80 mg to 6 mg after almost 2 years (in april) after initial blurred vision/AF. Have not had any serious side affects or major relapses, one incident with raised CRP/ESR while tapering at 40 but markers settled. Then out of the blue today had
Gilmor
in
PMRGCAuk
2 years ago
Ambroxol: Experimental treatment for PD
Does anyone know anything about the clinical trials going on in the UK with Ambroxol as a treatment for PD (a repurposed cough medicine)? The preliminary results look good. I understand that results have been released but I can't find It. Please reply if you have info. Thanks
Does anyone know anything about the clinical trials going on in the UK with Ambroxol as a treatment for PD (a repurposed cough medicine)? The preliminary results look good. I understand that results have been released but I can't find It. Please reply if you have info. Thanks
Badmouth
in
Cure Parkinson's
1 year ago
New Clinical Trial for Non-diabetic CKD
Researchers are looking for a better way to treat people who have nondiabetic chronic kidney disease (non-diabetic CKD). The trial treatment, finerenone, is being developed to help people who have chronic kidney disease (CKD). It works by blocking a certain hormone called aldosterone that causes injury
Researchers are looking for a better way to treat people who have nondiabetic chronic kidney disease (non-diabetic CKD). The trial treatment, finerenone, is being developed to help people who have chronic kidney disease (CKD). It works by blocking a certain hormone called aldosterone that causes injury
Bassetmommer
NKF Ambassador
in
Kidney Disease
1 year ago
[i][b]Evaluation of FT4 Levels by Immunoassay Requires Specific Reference Intervals in Pregnant Women[/b][/i]
[i]
Evaluation of FT4 Levels by Immunoassay Requires Specific Reference Intervals in Pregnant Women
[/i] [i][/i] [i]Eijun Nishihara and Takashi Akamizu[/i] [i]Published Online:14 Mar 2023https://doi.org/10.1089/ct.2023;35.93-95[/i] https://www.liebertpub.com/doi/10.1089/ct.2023%3B35.93-95
[i]
Evaluation of FT4 Levels by Immunoassay Requires Specific Reference Intervals in Pregnant Women
[/i] [i][/i] [i]Eijun Nishihara and Takashi Akamizu[/i] [i]Published Online:14 Mar 2023https://doi.org/10.1089/ct.2023;35.93-95[/i] https://www.liebertpub.com/doi/10.1089/ct.2023%3B35.93-95
helvella
Thyroid UK
in
Thyroid UK
1 year ago
cold face
I have systemic sclerosis, Raynaud’s, and fibromyalgia (plus other stuff). I also have stiffness and aching on the right side of my face neck and shoulder which I think is myofascial pain syndrome. However, those areas also feel very cold as though I am sitting in a draught . It can last for several
I have systemic sclerosis, Raynaud’s, and fibromyalgia (plus other stuff). I also have stiffness and aching on the right side of my face neck and shoulder which I think is myofascial pain syndrome. However, those areas also feel very cold as though I am sitting in a draught . It can last for several
Oleander1
in
Scleroderma & Raynaud's UK (SRUK)
2 years ago
A study record is now available on the Clinical Trials website for the big (N=330) Ambroxol Phase 3 trial (NCT05778617)
Recruitment Status: Not yet recruiting Estimated Study Start Date: September 2023 Estimated Study Completion Date: September 2028 Each participant will be taking ambroxol [or placebo] for two years, and it is estimated that it will take two years to recruit 330 PwPs. Ambroxol to Slow Progression
Recruitment Status: Not yet recruiting Estimated Study Start Date: September 2023 Estimated Study Completion Date: September 2028 Each participant will be taking ambroxol [or placebo] for two years, and it is estimated that it will take two years to recruit 330 PwPs. Ambroxol to Slow Progression
jeffreyn
in
Cure Parkinson's
1 year ago
Using modified virus to awaken your immune system to attack tumor
This is a promising future therapy for many cancers. The reason that we (I am) should be open to join clinical trial when possible: https://youtu.be/FEA6BQARqE8
This is a promising future therapy for many cancers. The reason that we (I am) should be open to join clinical trial when possible: https://youtu.be/FEA6BQARqE8
Cmdrdata
in
Advanced Prostate Cancer
1 year ago
chemotherapy
I had 3 round of taxol developed neuropathy and discontinued treatment but completed the 6 rounds of carboplatin. Neither treatments helped my cancer. Did Keytruda infusion with Lenvima pills not working. No approved therapists left, except for a clinical trial if I qualify and am accepted? Good luck
I had 3 round of taxol developed neuropathy and discontinued treatment but completed the 6 rounds of carboplatin. Neither treatments helped my cancer. Did Keytruda infusion with Lenvima pills not working. No approved therapists left, except for a clinical trial if I qualify and am accepted? Good luck
blondiec
in
British Heart Foundation
1 year ago
Possibly Failing Calquence - what’s next?
Turning to this very informative group for answers while waiting for my follow up visit after recent pet scan. Long story short hopefully… diagnosed in 2008 with cll, Started treatment in 2011 after biopsy of mass in nasopharynx turned out to be CLL related. Had 6 cycles of B& R, then maintenance Rituxan
Turning to this very informative group for answers while waiting for my follow up visit after recent pet scan. Long story short hopefully… diagnosed in 2008 with cll, Started treatment in 2011 after biopsy of mass in nasopharynx turned out to be CLL related. Had 6 cycles of B& R, then maintenance Rituxan
ReneeSusan
in
CLL Support
1 year ago
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