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Clinical depression
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I’m really really really upset
someone close to me got under my skin really well. I don’t know what to do after a fight I haven’t been in a fight in years I guess it’s gonna happen and I guess I’ll have to try to please the person since I have to live with him and try to calm down and try a bit harder in the work that I do that he
someone close to me got under my skin really well. I don’t know what to do after a fight I haven’t been in a fight in years I guess it’s gonna happen and I guess I’ll have to try to please the person since I have to live with him and try to calm down and try a bit harder in the work that I do that he
Starrlight
in
Anxiety and Depression Support
2 years ago
Lu-177 as SOC vs Clinical Trial
Many thanks to all contributors! Since I've now just had my 16th cabazitazel/carboplatin chemo treatment, we're looking at options and working on Lu-177. I'm curious that, since Lu-177 is now FDA approved and is Standard Of Care, is there an advantage to seeking a clinical trial vs receiving it as
Many thanks to all contributors! Since I've now just had my 16th cabazitazel/carboplatin chemo treatment, we're looking at options and working on Lu-177. I'm curious that, since Lu-177 is now FDA approved and is Standard Of Care, is there an advantage to seeking a clinical trial vs receiving it as
MechD
in
Advanced Prostate Cancer
2 years ago
Wilson’s Disease
Has anyone had their Cerebellar Ataxia re diagnosed as Wilson’s Disease? It’s apparently difficult to diagnose, but the neurological symptoms are similar.
Has anyone had their Cerebellar Ataxia re diagnosed as Wilson’s Disease? It’s apparently difficult to diagnose, but the neurological symptoms are similar.
Ostap
in
Ataxia UK
2 years ago
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New drug for treating hot flashes under FDA review
This article appeared in Natl Geographic's online daily. Because it is behind a paywall, I have copied it below. While the drug is primarily intended for menopausal women, the article notes that future beneficiaries could include men taking drugs for prostate cancer. Is it possible to cure hot
This article appeared in Natl Geographic's online daily. Because it is behind a paywall, I have copied it below. While the drug is primarily intended for menopausal women, the article notes that future beneficiaries could include men taking drugs for prostate cancer. Is it possible to cure hot
garyjp9
in
Advanced Prostate Cancer
2 years ago
Chemo/Pluvicto or Clinical Trial?
I have stage 4, mcrpc with mets to pelvic lymph nodes and prostate. ADT (Firmagon and Zytiga) kept PSA undetectable for ~2.5 years, then PSA started to rise. I had radiation to prostate in March of this year, which did not help. I started a clinical trial in October at NYU (LAVA 1207 immunotherapy)
I have stage 4, mcrpc with mets to pelvic lymph nodes and prostate. ADT (Firmagon and Zytiga) kept PSA undetectable for ~2.5 years, then PSA started to rise. I had radiation to prostate in March of this year, which did not help. I started a clinical trial in October at NYU (LAVA 1207 immunotherapy)
carguy
in
Advanced Prostate Cancer
2 years ago
Glycine : said to reduce symptoms and reduce aggregation
https://www.michaeljfox.org/grant/modulation-glycine-treatment-parkinsons-disease Glycine and N-acetylcysteine (GlyNAC) supplementation in older adults improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction, genotoxicity
https://www.michaeljfox.org/grant/modulation-glycine-treatment-parkinsons-disease Glycine and N-acetylcysteine (GlyNAC) supplementation in older adults improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction, genotoxicity
Little_apple
in
Cure Parkinson's
2 years ago
Details of Inhibikase Trial Suspension
Many of us have been following Inhibikase and the recent suspension of trials by the FDA. Inhibikase just issued a press release regarding the concerns expressed by the FDA. "The FDA raised several points, summarized below, in their explanation of the basis for the clinical hold: Further evaluation of
Many of us have been following Inhibikase and the recent suspension of trials by the FDA. Inhibikase just issued a press release regarding the concerns expressed by the FDA. "The FDA raised several points, summarized below, in their explanation of the basis for the clinical hold: Further evaluation of
jimcaster
in
Cure Parkinson's
2 years ago
Crushing depression
I am losing all energy to even try to get better. So sad, lifeless, barely functioning. And I don't care. Everything I try fails. It's misery to exist alone, isolated, no help in sight. So many problems that need attention but I have no motivation to do anything but sedate and sleep. My only escape
I am losing all energy to even try to get better. So sad, lifeless, barely functioning. And I don't care. Everything I try fails. It's misery to exist alone, isolated, no help in sight. So many problems that need attention but I have no motivation to do anything but sedate and sleep. My only escape
blue-green-purple
in
Anxiety and Depression Support
2 years ago
An exciting new clinical trial called STEM-PD is due to start in Sweden and the UK for Parkinson’s.
The symptoms of Parkinson’s are caused by the loss of dopamine-producing nerve cells or neurons in the brain; and researchers have long proposed using cell transplantation as a treatment option for replacing these lost dopamine cells. One challenge presented to research teams however has been generating
The symptoms of Parkinson’s are caused by the loss of dopamine-producing nerve cells or neurons in the brain; and researchers have long proposed using cell transplantation as a treatment option for replacing these lost dopamine cells. One challenge presented to research teams however has been generating
Farooqji
in
Cure Parkinson's
2 years ago
Bionic chip reveals how some antibiotics can harm kidneys
[i]
From left, Amir Livne, Dr. Gil Shamai and Prof. Ron Kimmel, the computer scientists who developed the neural network that examines breast cancer scans. Photo courtesy of the Technion – Israel Institute of Technology
[/i] Breakthrough technology blends sensors and human tissue in a smart kidney
[i]
From left, Amir Livne, Dr. Gil Shamai and Prof. Ron Kimmel, the computer scientists who developed the neural network that examines breast cancer scans. Photo courtesy of the Technion – Israel Institute of Technology
[/i] Breakthrough technology blends sensors and human tissue in a smart kidney
lupus-support1
Administrator
in
LUpus Patients Understanding and Support
2 years ago
Coaching misunderstood
Having coached allllllllll levels all ages for 45 years - people have NOOO concept of how personal coaching is.. they have to get up to the lesson prepare and are presenting and taking a risk that they aren t going to fail u or get mauled i know that... not easy riding for someone
Having coached allllllllll levels all ages for 45 years - people have NOOO concept of how personal coaching is.. they have to get up to the lesson prepare and are presenting and taking a risk that they aren t going to fail u or get mauled i know that... not easy riding for someone
Hidden
in
Anxiety and Depression Support
2 years ago
Anvils never cry, never get depression
Heard it seen it all my life from my Gen Patton super tough super lazy mother and her crowd....the head of the women liberation army....tough tough super tough women....only they do all the orders and we ..do all the work....hmm wonder why they ....alwys are fressh and never doubt never are tired always
Heard it seen it all my life from my Gen Patton super tough super lazy mother and her crowd....the head of the women liberation army....tough tough super tough women....only they do all the orders and we ..do all the work....hmm wonder why they ....alwys are fressh and never doubt never are tired always
Hidden
in
Anxiety and Depression Support
2 years ago
Irisin reduces AS aggregation
Amelioration of pathologic α-synuclein-induced Parkinson’s disease by irisin Irisin is an exercise-induced polypeptide secreted by skeletal muscle that crosses the blood–brain barrier and mediates certain effects of exercise. Here, we show that irisin prevents pathologic α-synuclein (α-syn)-induced
Amelioration of pathologic α-synuclein-induced Parkinson’s disease by irisin Irisin is an exercise-induced polypeptide secreted by skeletal muscle that crosses the blood–brain barrier and mediates certain effects of exercise. Here, we show that irisin prevents pathologic α-synuclein (α-syn)-induced
Little_apple
in
Cure Parkinson's
2 years ago
Has anyone benefitted from TMS?
I have recently been approved to receive 30 days (followed by 6 tapering treatments) of transcranial magnetic stimulation. It is giving me some "hope" that something might help me. My current episode of major depressive disorder and anxiety has disabled my in so many ways.
I have recently been approved to receive 30 days (followed by 6 tapering treatments) of transcranial magnetic stimulation. It is giving me some "hope" that something might help me. My current episode of major depressive disorder and anxiety has disabled my in so many ways.
KmarieG
in
Anxiety and Depression Support
2 years ago
Pluvicto increases radiographic progression-free survival (rPFS) before chemo
This is the early topline results from the
PSMAfore
trial. https://clinicaltrials.gov/ct2/show/NCT04689828 It tested whether giving Pluvicto increases radiographic progression-free survival (rPFS) in men who: (1) have failed one of the second-line hormonals (abiraterone, enzalutamide, darolutamide
This is the early topline results from the
PSMAfore
trial. https://clinicaltrials.gov/ct2/show/NCT04689828 It tested whether giving Pluvicto increases radiographic progression-free survival (rPFS) in men who: (1) have failed one of the second-line hormonals (abiraterone, enzalutamide, darolutamide
Tall_Allen
in
Advanced Prostate Cancer
2 years ago
On goin results on bomedemstat (LSD1 Inhibitor)
Hi All, I have been part of this great group for the last year or so, and although I wish none of us were here, I’m glad to have found an online community that shares the same concerns as myself. I’m 37 years old now and I was diagnosed with ET in 2009 when I was 24, so it was kind of a shock, but
Hi All, I have been part of this great group for the last year or so, and although I wish none of us were here, I’m glad to have found an online community that shares the same concerns as myself. I’m 37 years old now and I was diagnosed with ET in 2009 when I was 24, so it was kind of a shock, but
jafar09
in
MPN Voice
2 years ago
Naringenin (NAR), a natural flavonoid, exhibits neuroprotection against PD-related pathology.
https://www.sciencedirect.com/science/article/abs/pii/S0028390821003865 Naringenin: A prospective therapeutic agent for Alzheimer's and Parkinson's disease https://onlinelibrary.wiley.com/doi/abs/10.1111/jfbc.14415 of substantial evidence for naringenin's neuroprotective efficacy in several experimental
https://www.sciencedirect.com/science/article/abs/pii/S0028390821003865 Naringenin: A prospective therapeutic agent for Alzheimer's and Parkinson's disease https://onlinelibrary.wiley.com/doi/abs/10.1111/jfbc.14415 of substantial evidence for naringenin's neuroprotective efficacy in several experimental
Little_apple
in
Cure Parkinson's
2 years ago
Broccoli Sprout Beverage can clear Acrolein
I am doing a deep dive on the benefits of Broccoli Sprouts and/or Sulforaphane. There seem to be a lot of benefits, so I am posting on them one benefit at a time. As I post more information, I will add the new information to a master document on Broccoli Sprouts - Sulforaphane so we end up with a cohesive
I am doing a deep dive on the benefits of Broccoli Sprouts and/or Sulforaphane. There seem to be a lot of benefits, so I am posting on them one benefit at a time. As I post more information, I will add the new information to a master document on Broccoli Sprouts - Sulforaphane so we end up with a cohesive
Bolt_Upright
in
Cure Parkinson's
2 years ago
Antipsychotics
my daughter who is 44 has had personality disorder problems since the age of 16. However she has managed a marriage and bringing up two teenage boys . She is now divorced but has a good friendly relationship with her ex. I hate to see some of the meds she seemingly has to take but the latest prescription
my daughter who is 44 has had personality disorder problems since the age of 16. However she has managed a marriage and bringing up two teenage boys . She is now divorced but has a good friendly relationship with her ex. I hate to see some of the meds she seemingly has to take but the latest prescription
m1946
in
Restless Legs Syndrome
2 years ago
Chronic lymphocytic leukemia treatment algorithm 2022
This 29 November 2022 review article published in the [i]Blood Cancer Journal[/i] presents an up-to-date treatment algorithm for CLL. https://www.nature.com/articles/s41408-022-00756-9 [i]"The treatment landscape for patients with chronic lymphocytic leukemia (CLL) has changed considerably with the
This 29 November 2022 review article published in the [i]Blood Cancer Journal[/i] presents an up-to-date treatment algorithm for CLL. https://www.nature.com/articles/s41408-022-00756-9 [i]"The treatment landscape for patients with chronic lymphocytic leukemia (CLL) has changed considerably with the
CLLerinOz
Administrator
in
CLL Support
2 years ago
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