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Results of a Phase 1b trial of MODAG's oligomer modulator anle138b evaluating the safety tolerability in healthy volunteers
Results of a Phase 1b randomised, double-blind, placebo-controlled clinical trial evaluating the safety, tolerability & pharmacokinetics of MODAG's oligomer modulator anle138b (which is being developed for #Parkinsons) have been published. Roll on Phase 2! healthy volunteers were screened and 68 participants
Results of a Phase 1b randomised, double-blind, placebo-controlled clinical trial evaluating the safety, tolerability & pharmacokinetics of MODAG's oligomer modulator anle138b (which is being developed for #Parkinsons) have been published. Roll on Phase 2! healthy volunteers were screened and 68 participants
Hidden
in
Cure Parkinson's
2 years ago
Therapeutic effects of oral liothyronine on aluminum phosphide poisoning as an adjuvant therapy: A clinical trial
Over the years, we have often seen thyroid hormones mentioned in fields of medicines other than endocrinology. In particular, cardiac medics have often seemed to understand some things better than others. This paper really surprised me as I don't remember any previous paper which even hinted at this
Over the years, we have often seen thyroid hormones mentioned in fields of medicines other than endocrinology. In particular, cardiac medics have often seemed to understand some things better than others. This paper really surprised me as I don't remember any previous paper which even hinted at this
helvella
Thyroid UK
in
Thyroid UK
2 years ago
CLL Society This Week (USA Support Organization) - With Online Resources Available to All CLL Patients Worldwide
Sign Up to have CLL Society’s newsletter: This Week! delivered to your email inbox every Tuesday!: https://cllsociety.org/newsletter-sign-up/
SPECIAL FEATURE: CLL Resources
CLL Society aims to provide all those living with CLL/SLL the resources they need to conquer their diagnosis
Sign Up to have CLL Society’s newsletter: This Week! delivered to your email inbox every Tuesday!: https://cllsociety.org/newsletter-sign-up/
SPECIAL FEATURE: CLL Resources
CLL Society aims to provide all those living with CLL/SLL the resources they need to conquer their diagnosis
lankisterguy
Volunteer
in
CLL Support
2 years ago
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Staying in bed against better judgment and experience while everything else is getting MUCH better (+ description of ACT therapy)
Hello! I hope everyone is as well as can be under your circumstances. Personally, I've been doing MUCH better lately. I can handle an increase in my work schedule (4 hours per day now). Not yet full time, but it's been getting better almost steadily. I've been able to go for walks AND ENJOY THEM! I've
Hello! I hope everyone is as well as can be under your circumstances. Personally, I've been doing MUCH better lately. I can handle an increase in my work schedule (4 hours per day now). Not yet full time, but it's been getting better almost steadily. I've been able to go for walks AND ENJOY THEM! I've
Eklektik
in
Anxiety and Depression Support
2 years ago
I know it's all lies but it feels so real
I feel like a burden and a horrible person. I am always about to start crying. I am a manager and supervisor, so I have to pretend to be a competent person during the day. I try to restrain my tears at night because I don't want to burden my husband. I have been under treatment for depression and
I feel like a burden and a horrible person. I am always about to start crying. I am a manager and supervisor, so I have to pretend to be a competent person during the day. I try to restrain my tears at night because I don't want to burden my husband. I have been under treatment for depression and
dreamingofmountains
in
Anxiety and Depression Support
2 years ago
Exelixis Clinical trial XL091 pill and Tecentriq (Atezolizumab)
Anyone with advanced breast cancer er/pr+, her2 neg, asked to do this trial? I am a bit concerned because I was dx with luminal A in 2016 and had a lumpdectumyin left breast. Found lymphnodes too. Had 12 rounds of chemo and 18 days of rads. Was on anastrozle until Dec of 2019 with progression, mets.
Anyone with advanced breast cancer er/pr+, her2 neg, asked to do this trial? I am a bit concerned because I was dx with luminal A in 2016 and had a lumpdectumyin left breast. Found lymphnodes too. Had 12 rounds of chemo and 18 days of rads. Was on anastrozle until Dec of 2019 with progression, mets.
Hopeful4Cure
in
SHARE Metastatic Breast Cancer
2 years ago
Low-Carb Diet, Gut Microbiome, Leaky Gut, etc.
New study from the CAPS2 (Carbohydrate and Prostate Study 2) team. led by Steve Freedland. "Accumulating evidence suggest a role of gut microbiota in urologic health including prostate cancer (PC), potentially via its impact on intestinal permeability (IP). When the gut microbiota community is disrupted
New study from the CAPS2 (Carbohydrate and Prostate Study 2) team. led by Steve Freedland. "Accumulating evidence suggest a role of gut microbiota in urologic health including prostate cancer (PC), potentially via its impact on intestinal permeability (IP). When the gut microbiota community is disrupted
pjoshea13
in
Advanced Prostate Cancer
2 years ago
Dipyridamole update
I have been on 100mg x2, one at about 4pm and one closer to 8pm. It is recommended to take Dipyridamole on an empty stomach. This is still lower than the effective dosage in the study and I intend to increase it. I have cut pregabalin from 300mg to 150mg. My goal is to cut it again when the 150mg
I have been on 100mg x2, one at about 4pm and one closer to 8pm. It is recommended to take Dipyridamole on an empty stomach. This is still lower than the effective dosage in the study and I intend to increase it. I have cut pregabalin from 300mg to 150mg. My goal is to cut it again when the 150mg
WideBody
in
Restless Legs Syndrome
2 years ago
Combined vitamin D, omega-3 fatty acids and a simple exercise program may reduce cancer risk among active adults aged 70 plus
In the "DO-HEALTH" randomized clinical trial with 2,157 relatively healthy participants aged 70 plus, supplementation with daily high-dose vitamin D3 plus omega-3s, combined with a simple home exercise program (SHEP), showed no significant improvement in systolic or diastolic blood pressure, nonvertebral
In the "DO-HEALTH" randomized clinical trial with 2,157 relatively healthy participants aged 70 plus, supplementation with daily high-dose vitamin D3 plus omega-3s, combined with a simple home exercise program (SHEP), showed no significant improvement in systolic or diastolic blood pressure, nonvertebral
bennevisplace
in
CLL Support
2 years ago
“The drug development landscape in Parkinson’s” by Dr Kevin McFarthing - video recording now available
Thank you to all of you who joined us on Monday to listen to Dr Kevin McFarthing talk to us about “The drug development landscape in Parkinson’s”. Kevin's presentation provides a comprehensive overview of Parkinson's research but also focuses specifically on: - ENT-01, derived from the liver of the
Thank you to all of you who joined us on Monday to listen to Dr Kevin McFarthing talk to us about “The drug development landscape in Parkinson’s”. Kevin's presentation provides a comprehensive overview of Parkinson's research but also focuses specifically on: - ENT-01, derived from the liver of the
Michel0220
in
Cure Parkinson's
2 years ago
High LDH and increasing
Hi, this is my first post. i have non cirrhotic portal hypertension (caused by sepsis,4 years ago) with varies in gut stomach and now also oesophagus. Last year, from around March I felt really unwell and I had blood tests taken privately. My LDH was 771. My NHS consultant arranged for further tests
Hi, this is my first post. i have non cirrhotic portal hypertension (caused by sepsis,4 years ago) with varies in gut stomach and now also oesophagus. Last year, from around March I felt really unwell and I had blood tests taken privately. My LDH was 771. My NHS consultant arranged for further tests
PiperAlfie
in
CLL Support
2 years ago
Diagnosed with Polyhydramnios at 27 weeks
Hi there, I went for a private 3D scan at 27+3 and they said my amniotic was 9cm (the most it should be is 8cm) and that I should call my midwife. Other than that the baby looked great and healthy albeit a bit bigger than average. The midwives got me in for an extra scan with them today and confirmed
Hi there, I went for a private 3D scan at 27+3 and they said my amniotic was 9cm (the most it should be is 8cm) and that I should call my midwife. Other than that the baby looked great and healthy albeit a bit bigger than average. The midwives got me in for an extra scan with them today and confirmed
PurpleCloud1
in
Pregnancy and Parenting Support
2 years ago
Mirtazapine
I have been on this drug for 2 months for anxiety and depression . I am now on the maximum dose and have just experienced a sleepless night . Has anyone else experienced this and what did you do ?
I have been on this drug for 2 months for anxiety and depression . I am now on the maximum dose and have just experienced a sleepless night . Has anyone else experienced this and what did you do ?
19jane
in
Anxiety and Depression Support
2 years ago
Never before anxiety symptoms
Hello, I am a 49 year old who has dealt with anxiety, depression since I was a teen. I have managed for many years with exercise when I was younger and meds as I get older and exercise less. The last two years have been super stressful as I became a teacher and started remote teaching. I had a nervous
Hello, I am a 49 year old who has dealt with anxiety, depression since I was a teen. I have managed for many years with exercise when I was younger and meds as I get older and exercise less. The last two years have been super stressful as I became a teacher and started remote teaching. I had a nervous
Shellover
in
Anxiety Support
2 years ago
What do you think of Low-Dose Lithium?
1) How long have you taken? [Since 1/6/22 (18 days)] 2) What improvements have you noticed? [Positive effect on Mood, Less Anxiety, more Social.] 3) What improvements in PD have you noticed? [I feel very positive, but too early to tell for sure. I have cut back on on l-dopa (5 to 4 a day).] 4) What
1) How long have you taken? [Since 1/6/22 (18 days)] 2) What improvements have you noticed? [Positive effect on Mood, Less Anxiety, more Social.] 3) What improvements in PD have you noticed? [I feel very positive, but too early to tell for sure. I have cut back on on l-dopa (5 to 4 a day).] 4) What
Gcf51
in
Cure Parkinson's
2 years ago
Stem Cell Delivery Routes
amykp got me looking to answer the question of why Hope Biosciences was not using intracranial deliver for their stem cell trial for PD. I found this: Stem Cells: Innovative Therapeutic Options for Neurodegenerative Diseases? 2021 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8391848/ "3. Routes
amykp got me looking to answer the question of why Hope Biosciences was not using intracranial deliver for their stem cell trial for PD. I found this: Stem Cells: Innovative Therapeutic Options for Neurodegenerative Diseases? 2021 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8391848/ "3. Routes
Bolt_Upright
in
Cure Parkinson's
2 years ago
Salmon Protein Hydrolysate
New study below [1]. Anyone here using
Salmon Protein Hydrolysate
? FWIW: "A growing body of evidence implicates iron dysmetabolism in prostate cancer progression. A bioactive peptide-rich salmon protein hydrolysate (SPH) has previously been demonstrated to modulate iron homeostatic mechanisms.
New study below [1]. Anyone here using
Salmon Protein Hydrolysate
? FWIW: "A growing body of evidence implicates iron dysmetabolism in prostate cancer progression. A bioactive peptide-rich salmon protein hydrolysate (SPH) has previously been demonstrated to modulate iron homeostatic mechanisms.
pjoshea13
in
Advanced Prostate Cancer
2 years ago
Feeling sad for no reason
I’ll come straight to the point. I was watching a movie a few minutes ago when out of nowhere I started feeling really really low. It was so overwhelming that I stopped the film, changed my chair to one where I can lean back and have been listening to podcasts of mental health and some comedy. As I’m
I’ll come straight to the point. I was watching a movie a few minutes ago when out of nowhere I started feeling really really low. It was so overwhelming that I stopped the film, changed my chair to one where I can lean back and have been listening to podcasts of mental health and some comedy. As I’m
Joeyman
in
Anxiety and Depression Support
2 years ago
Was finally happy again
A while ago I was off my meds and felt terrible, started taking my zoloft again with l-methylfolate since my psychiatrist suggested it and felt great. . well now I’m pregnant and my gyno said not to take the l methylfolate - my depression is coming back, not as hard as it was without the zoloft but holy
A while ago I was off my meds and felt terrible, started taking my zoloft again with l-methylfolate since my psychiatrist suggested it and felt great. . well now I’m pregnant and my gyno said not to take the l methylfolate - my depression is coming back, not as hard as it was without the zoloft but holy
stressedndepressed
in
Anxiety and Depression Support
2 years ago
Signed up for Living beyond Breast Cancer symposium, sharing info.
Saw this clinical trial for TNBC https://www.gileadclinicaltrials.com/study/?id=GS-US-586-6144 IF I come across any interesting info. I will share. Hope that is ok!
Saw this clinical trial for TNBC https://www.gileadclinicaltrials.com/study/?id=GS-US-586-6144 IF I come across any interesting info. I will share. Hope that is ok!
DDIL1
in
SHARE Metastatic Breast Cancer
2 years ago
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