Glycine : said to reduce symptoms and reduce aggregation

[Little_apple]

michaeljfox.org/grant/modul...

Glycine and N-acetylcysteine (GlyNAC) supplementation in older adults improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction, genotoxicity, muscle strength, and cognition: Results of a pilot clinical trial

onlinelibrary.wiley.com/doi...

sciencedirect.com/science/a...

Should I / we , supplement with glycine?

[Kia17]

Because of contradictory research about glycine inhibitory effects in the spinal cord and brainstem and it’s excitatory roles on the CNS , I stopped taking glycine supplement assuming that we take enough glycine from our diet but I am continuing taking NAC.

[Little_apple in reply to Kia17]

Glycine accomplishes several functions as a transmitter in the central nervous system (CNS). As an inhibitory neurotransmitter, it participates in the processing of motor and sensory information that permits movement, vision, and audition.

pubmed.ncbi.nlm.nih.gov/113...

It’s both excitatory and inhibitory

I’m looking for info regarding what you said.

[Kia17 in reply to Little_apple]

l used to take Glycine for its “inhibitory” effects on the CNS but later learnt it has excitatory role on some areas of brain instead and its inhibitory effect are limited to spinal cord and brainstem.

[Bolt_Upright]

Thank you for getting me to re-review my stance on Glycine!

So I was taking Glycine (and Taurine and NAC) together up until a year ago, when I made this post (you should read through it): Time to Cut Glycine from my Stack? (this would include GlyNAC) healthunlocked.com/cure-par...

Without re-reading all the documents in my first post, the mayor points seemed to be

A) The ability of homocisteine to do neurological harm depends on glycine levels. Without the glycine the homocisteine can only do a fraction of the damage: The Controversial Role of Homocysteine in Neurology: From Labs to Clinical Practice 2019 ncbi.nlm.nih.gov/pmc/articl...

B) Glycine has also been implicated in demyelination: The Inhibitory Neurotransmitter Glycine Modulates Macrophage Activity by Activation of Neutral Amino Acid Transporters 2009 sci-hub.se/10.1002/jnr.22395

I stopped Glycine cold.

Then about two months ago I added Glycine back to my stack. I probably added it back because A) I have a lot of Glycine in my cupboard leftover from when I was taking it, and B) I had forgotten the bad things I read about Glycine.

This is one of the pages you linked to. This is the full article: Glycine and N-acetylcysteine (GlyNAC) supplementation in older adults improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction, enotoxicity, muscle strength, and cognition: Results of a pilot clinical trial 2021 sci-hub.se/10.1002/ctm2.372

"This study found that compared to healthy young adults, older humans have severely elevated oxidative stress, glutathione deficiency, impaired mitochondrial function, increased inflammation, insulin resistance and endothelial dysfunction, and lower muscle strength and mental cognition. We tested and found that supplementing GlyNAC (combination of glycine and N-acetylcysteine) improved all these defects, and that stopping GlyNAC resulted in a loss of benefits. The results of this trial suggests that GlyNAC supplementation could be a simple, safe and effective nutritional strategy to boost cellular defenses to protect against oxidative stress, correct mitochondrial defects to improve energy availability, increase muscle strength and cognition, and thereby promote healthy aging in humans."

"CONCLUSIONS: The results of this trial suggest that GlyNAC supplementation in OA is well tolerated and could play a novel role in improving healthy aging in OA by correcting GSH deficiency, OxS, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction, body fat, muscle strength, gait speed, and cognitive function. GlyNAC supplementation also appears to improve hallmark defects in aging, which could be an exciting discovery and needs to be confirmed in future studies. Dietary supplementation of GlyNAC could improve the cellular, mitochondrial, and metabolic health of OA, improve strength and cognition, and thereby promote healthy aging. No side-effects of GlyNAC supplementation were detected during 36-week duration of the study. The results of this study support the need for future trials to assess the effects of GlyNAC supplementation in a larger population of OAs receiving GlyNAC supplementation for a longer duration."

There were only 8 older people in the trial, but the results looked really good. Especially table 4 and table 6.

The thing about evaluating treatments when you have PD, or any disease, is that it is not like nothing bad is going to happen to you if you don't take the treatment. There is hopefully a reward to go along with the risk and maybe (maybe) you can avoid the status quo risk. Or maybe you will make things worse.

It is still a coin toss. To win this game I need to move the needle, so for now I am in on Glycine. Personally, I take 1200 mg NAC, 1000 mg Taurine, and 1000 mg of Glycine together about 30 minutes before bed. There are articles showing combinations of these supplements work better together than separately.

[Little_apple in reply to Bolt_Upright]

thank you. I need to revisit taurine.

[gaga1958 in reply to Bolt_Upright]

what does taurine benefit?

is this combination helpful for sleep and that's why you take at night?

[Little_apple in reply to gaga1958]

Taurine is a type of amino acid that aids in calming anxiety levels by supporting the function of the neurotransmitter GABA, which allows the brain to shut off and encourages rest. Supplements containing 1 to 3 grams of taurine should be taken before bedtime to see full benefits

everwellrx.com/blog/8-sleep...

[ssrs in reply to Bolt_Upright]

Which brand of glycine do you use? I am thinking about having my husband try it to possibly help him sleep longer than an hour at a time.

Thanks!

[Bolt_Upright in reply to ssrs]

This is the Glycine I was taking (I stopped taking it again. I can't find notes on why I stopped): Life Extension Glycine 1000 mg – Promotes Relaxation, Healthy Sleep, Glucose + Fructose Metabolism – Gluten-Free, Non-GMO, Vegetarian – 100 Vegetarian Capsules amazon.com/gp/product/B00B3...

[ssrs in reply to Bolt_Upright]

Thank you! I also meant to ask which taurine do you use? Do you use the Solgar B1? Amazon doesn’t have it and the Solgar website is out of it as well….

Thanks Bolt!!

[Bolt_Upright in reply to ssrs]

I have kinks to all of my sources on my stack page: rbd-pd-protocols.blogspot.c...

[Sun_and_flowers]

I found this yesterday, with lots of references:

theepochtimes.com/health/gl...

[Sun_and_flowers in reply to Sun_and_flowers]

Although I disagree with what they say at the very end about ingesting collagen. Collagen is a protein, like other types of proteins; proteins are made up of amino acids, and when you ingest a protein, of any kind, the body breaks it down into the amino acids that make it up, to make use of them as it sees fit, to make up new proteins with them, but not necessarily the protein it was when you first ingested it, so basically, an ingested protein is a pack of amino acids that we can buy depending on our needs, in this particular case, glycine.