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Terbium-161 instead of Lutetium-177
Here's an intriguing abstract from the ASCO conference that is going on right now (February 2023). Hofman and company in Australia are starting a clinical trial (NCT05521412) to evaluate using Tb-161 instead of Lu-177 linked to the PSMA-I&T targeting ligand. The hope is that the shorter range and higher
Here's an intriguing abstract from the ASCO conference that is going on right now (February 2023). Hofman and company in Australia are starting a clinical trial (NCT05521412) to evaluate using Tb-161 instead of Lu-177 linked to the PSMA-I&T targeting ligand. The hope is that the shorter range and higher
TeleGuy
in
Advanced Prostate Cancer
1 year ago
177LU-DTPA-SC16 attaching DLL3 for neuroendocrine cancer
25% of pCA develop into neuroendocrine variant. Research show good preclinical results. Has anyone information of a clinical trial at MSKCC using SC16 as a monoclonal antibody? https://pubmed.ncbi.nlm.nih.gov/35759660/
25% of pCA develop into neuroendocrine variant. Research show good preclinical results. Has anyone information of a clinical trial at MSKCC using SC16 as a monoclonal antibody? https://pubmed.ncbi.nlm.nih.gov/35759660/
Hidden
in
Advanced Prostate Cancer
1 year ago
đź“š Research 101: Who can take part in a clinical trial?
All clinical trials have guidelines about who can participate. Before joining a clinical trial, a participant must qualify for the study. The factors that allow someone to participate in a clinical trial are called "inclusion criteria" and those that disallow someone from participating are called "exclusion
All clinical trials have guidelines about who can participate. Before joining a clinical trial, a participant must qualify for the study. The factors that allow someone to participate in a clinical trial are called "inclusion criteria" and those that disallow someone from participating are called "exclusion
AnnaHU
HealthUnlocked
in
Research Opportunities
1 year ago
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Calquence and mouth issues?
I’m wondering if anyone taking Calquence has experienced white patches in their mouth? My dentist noticed I have one on my tongue side of gums. It doesn’t hurt and can’t be scraped off (fits the description of leukoplakia when I Google). My dentist thought it looked like trauma and said to call if it
I’m wondering if anyone taking Calquence has experienced white patches in their mouth? My dentist noticed I have one on my tongue side of gums. It doesn’t hurt and can’t be scraped off (fits the description of leukoplakia when I Google). My dentist thought it looked like trauma and said to call if it
CoCoLuna11
in
CLL Support
2 years ago
Focal Ablation doesn't work (again)
Cryo joins HIFU, FLA, and IRE as substandard focal thermoablation therapies. Aker et al. reported (below) that on biopsy 18 months post-treatment, 35% still had clinically significant prostate cancer (only 46% had no prostate cancer), and that neither MRI nor PSA were good indicators of treatment failure
Cryo joins HIFU, FLA, and IRE as substandard focal thermoablation therapies. Aker et al. reported (below) that on biopsy 18 months post-treatment, 35% still had clinically significant prostate cancer (only 46% had no prostate cancer), and that neither MRI nor PSA were good indicators of treatment failure
Tall_Allen
in
Prostate Cancer Network
1 year ago
Ambroxol
Would anyone share if you have participated in a clinical trial using the drug Ambroxol for PD? There have been several clinical trials which have published encouraging resusts, mostly in the UK. I am not formally in a trial but have been duplicating the dosage for about 12 months. My experience is favorable
Would anyone share if you have participated in a clinical trial using the drug Ambroxol for PD? There have been several clinical trials which have published encouraging resusts, mostly in the UK. I am not formally in a trial but have been duplicating the dosage for about 12 months. My experience is favorable
Badmouth
in
Cure Parkinson's
1 year ago
Any advice about future treatment?
Good morning sisters, I am at yet another crossroads and hoping for some advice. Diagnosed stage 4 high grade serous Jan 2020, had two surgeries, three courses of chemo (in total), short lived Niraparib, failed clinical trial (PICCOLO). So now having the 6th and final chemo of this third course ( Carboplatin
Good morning sisters, I am at yet another crossroads and hoping for some advice. Diagnosed stage 4 high grade serous Jan 2020, had two surgeries, three courses of chemo (in total), short lived Niraparib, failed clinical trial (PICCOLO). So now having the 6th and final chemo of this third course ( Carboplatin
Riverflo
in
My Ovacome
1 year ago
To those who replied to my question on clinical trials
To those who replied to my question on joining clinical trials, I am overwhelmed by your kindness in sending me emails. I will answer your emails soon but I am currently recovering from a cataract operation and though my eyesight has improved a lot I still have difficulty reading and writing. Bear
To those who replied to my question on joining clinical trials, I am overwhelmed by your kindness in sending me emails. I will answer your emails soon but I am currently recovering from a cataract operation and though my eyesight has improved a lot I still have difficulty reading and writing. Bear
MyMiracle13
in
SHARE Metastatic Breast Cancer
1 year ago
My life …
so I have been struggling with PTSD, Depression and Anxiety. I can’t stop crying because of my teams. Does anyone have any ideas??
so I have been struggling with PTSD, Depression and Anxiety. I can’t stop crying because of my teams. Does anyone have any ideas??
Isturgglewithptsd
in
Anxiety and Depression Support
2 years ago
Effect of Melatonin Administration on Mitochondrial Activity and Oxidative Stress Markers in Patients with Parkinson's Disease 2021
Effect of Melatonin Administration on Mitochondrial Activity and Oxidative Stress Markers in Patients with Parkinson's Disease 2021
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8545577/ Abstract Mitochondrial dysfunction and oxidative stress are extensively linked to Parkinson's disease (PD)
Effect of Melatonin Administration on Mitochondrial Activity and Oxidative Stress Markers in Patients with Parkinson's Disease 2021
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8545577/ Abstract Mitochondrial dysfunction and oxidative stress are extensively linked to Parkinson's disease (PD)
Bolt_Upright
in
Cure Parkinson's
1 year ago
IVIG after heart surgery and stopping IBRUTIMIB
12 months ago I was on an Ibrutinib clinical trial for my CLL. Ibrutinib worked great for me for years. I found out I needed a triple bypass due to 95% LAD artery blockage. Not good! A stent wasn’t an option in my case due to necessity for blood thinners. Can’t do blood thinners, aspirin and Irbutinib
12 months ago I was on an Ibrutinib clinical trial for my CLL. Ibrutinib worked great for me for years. I found out I needed a triple bypass due to 95% LAD artery blockage. Not good! A stent wasn’t an option in my case due to necessity for blood thinners. Can’t do blood thinners, aspirin and Irbutinib
misterbee
in
CLL Support
1 year ago
Depression?
Hello. Two years into PMR journey. I am at 3mg pred and physically feel well. I am having bouts of severe depression and have never been depressed before. I am 59 years old and started menopause at 57 years old. Could it be a flare , adrenals or "the menopause"? Any info from the ladies would help
Hello. Two years into PMR journey. I am at 3mg pred and physically feel well. I am having bouts of severe depression and have never been depressed before. I am 59 years old and started menopause at 57 years old. Could it be a flare , adrenals or "the menopause"? Any info from the ladies would help
paleolady
in
PMRGCAuk
2 years ago
“If Who is on First, What is on Second; No, He is on Third” (TTFD, Allithiamine, Fursultiamine)
TTFD is a B1 (Thiamine Tetrahydrofurfuryl Disulfide) The chemical Allithiamine (thiamine allyl disulfide or TAD) https://en.wikipedia.org/wiki/Allithiamine The product Allithiamine does not contain Allithiamine, it contains 50mg of TTFD https://www.walmart.com/ip/Allithiamine-Vitamin-B1-50-mg-250-Capsules-Ecological-Formulas
TTFD is a B1 (Thiamine Tetrahydrofurfuryl Disulfide) The chemical Allithiamine (thiamine allyl disulfide or TAD) https://en.wikipedia.org/wiki/Allithiamine The product Allithiamine does not contain Allithiamine, it contains 50mg of TTFD https://www.walmart.com/ip/Allithiamine-Vitamin-B1-50-mg-250-Capsules-Ecological-Formulas
Gcf51
in
Cure Parkinson's
2 years ago
Volunteer Opportunity - Prostate Cancer Patient Advocate with SWOG for Genitourinary Cancer Committee
I have served as a volunteer Patient Advocate representing the LGBTQ+ Community with the Southwest Oncology Group (SWOG) for the past two years. As such I am serving as a member of the Patient Advocacy Committee (PAC) and the Diversity, Equality, and Inclusion Committee. I attend monthly zoom meetings
I have served as a volunteer Patient Advocate representing the LGBTQ+ Community with the Southwest Oncology Group (SWOG) for the past two years. As such I am serving as a member of the Patient Advocacy Committee (PAC) and the Diversity, Equality, and Inclusion Committee. I attend monthly zoom meetings
JRPnSD
in
Advanced Prostate Cancer
1 year ago
HAS ANYONE PARTICIPATED IN CLINICAL TRIALS
Hello everyone. Has anybody on this forum ever joined in a clinical trial? I have been invited to join a Phase 1 clinical trial for LOXO-783. The new drug is for those who have the PIK3CA mutation. At first I was very excited to join but when I was looking at the screening requirements, I don’t
Hello everyone. Has anybody on this forum ever joined in a clinical trial? I have been invited to join a Phase 1 clinical trial for LOXO-783. The new drug is for those who have the PIK3CA mutation. At first I was very excited to join but when I was looking at the screening requirements, I don’t
MyMiracle13
in
SHARE Metastatic Breast Cancer
1 year ago
response to clinical trial application?
A couple of months ago, I applied for a clinical trial that had just started recruiting. They are still recruiting and have begun administering the trial drug to participants. I never heard from trial staff. Has anyone applied for a trial and received notice whether they were rejected? Thank you. Sashay
A couple of months ago, I applied for a clinical trial that had just started recruiting. They are still recruiting and have begun administering the trial drug to participants. I never heard from trial staff. Has anyone applied for a trial and received notice whether they were rejected? Thank you. Sashay
Sashay2020
in
My Ovacome
1 year ago
B12 levels
I thought it was my
clinical
depression
to blame and my meds have been increased. Dr says my B12 levels are ok and I don’t have to adjust the timing of 12 weeks. Still no better. Does anybody have any suggestions to why I’m still very tired.
I thought it was my
clinical
depression
to blame and my meds have been increased. Dr says my B12 levels are ok and I don’t have to adjust the timing of 12 weeks. Still no better. Does anybody have any suggestions to why I’m still very tired.
Diamonds_
in
Pernicious Anaemia Society
2 years ago
Interesting video with active ongoing clinical trial. Maybe on option for some!!
https://www.urotoday.com/video-lectures/asco-2022/video/2853-the-future-of-radiopharmaceuticals-in-the-treatment-of-prostate-cancer-philip-kantoff.html
https://www.urotoday.com/video-lectures/asco-2022/video/2853-the-future-of-radiopharmaceuticals-in-the-treatment-of-prostate-cancer-philip-kantoff.html
Bkraus1
in
Advanced Prostate Cancer
1 year ago
More on the biomarker NFL
The identification of disease-modifying therapies is the Holy Grail of PD research, but to date no drug has been approved as such a therapy.1 Â There are numerous disease-modifying therapies currently in the pipeline attempting to modify the underlying pathomechanisms. In recent years, the results of
The identification of disease-modifying therapies is the Holy Grail of PD research, but to date no drug has been approved as such a therapy.1 Â There are numerous disease-modifying therapies currently in the pipeline attempting to modify the underlying pathomechanisms. In recent years, the results of
House2
in
Cure Parkinson's
1 year ago
Annovis Bio Announces Approval for EU Clinical Trial Sites for the Phase 3 Study of Buntanetap for the Treatment of Parkinson's Disease
This trial is already open in the United States, and I believe some on this forum are participating. This announcemment indicates that the company is also opening clinical trial sites across the EU. I checked clnicaltrials.gov but they have not listed the EU sites yet. https://www.prnewswire.com/news-releases
This trial is already open in the United States, and I believe some on this forum are participating. This announcemment indicates that the company is also opening clinical trial sites across the EU. I checked clnicaltrials.gov but they have not listed the EU sites yet. https://www.prnewswire.com/news-releases
Canddy
in
Cure Parkinson's
1 year ago
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