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Treatment After Progression in Metastatic Castration-Resistant Prostate Cancer: some options
https://www.onclive.com/view/piecing-the-puzzle-together-treatment-after-progression-in-metastatic-
castration
-resistant-prostate-cancer
https://www.onclive.com/view/piecing-the-puzzle-together-treatment-after-progression-in-metastatic-
castration
-resistant-prostate-cancer
Maxone73
in
Advanced Prostate Cancer
4 months ago
Interesting PSA observation
A PSA flare can be a side effect of this chemo & medications, not necessarily a sign of
castration
resistance.
A PSA flare can be a side effect of this chemo & medications, not necessarily a sign of
castration
resistance.
Nusch
in
Advanced Prostate Cancer
11 months ago
FDA Fast Track Designation for 225Ac-FL-020 for mCRPCa
https://www.morningstar.com/news/pr-newswire/20240702cn52116/full-life-technologies-granted-fda-fast-track-designation-for-225ac-fl-020-for-the-treatment-of-metastatic-
castration
-resistant-prostate-cancer
https://www.morningstar.com/news/pr-newswire/20240702cn52116/full-life-technologies-granted-fda-fast-track-designation-for-225ac-fl-020-for-the-treatment-of-metastatic-
castration
-resistant-prostate-cancer
Maxone73
in
Advanced Prostate Cancer
15 days ago
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In vivo/vitro: Dickkopf-1 (DKK1) drives growth and metastases in castration-resistant prostate cancer
https://communities.springernature.com/posts/dickkopf-1-dkk1-drives-growth-and-metastases-in-
castration
-resistant-prostate-cancer
https://communities.springernature.com/posts/dickkopf-1-dkk1-drives-growth-and-metastases-in-
castration
-resistant-prostate-cancer
Maxone73
in
Advanced Prostate Cancer
2 months ago
Hormonal injections and oral hormones
Hi guys, we talked so much about oral hormones like Casadox, Xtandi, etc. being
castration
resistant. 1. Can hormone injections like Lupron, Zoladex, etc. be also
castration
resistant?
Hi guys, we talked so much about oral hormones like Casadox, Xtandi, etc. being
castration
resistant. 1. Can hormone injections like Lupron, Zoladex, etc. be also
castration
resistant?
tarzantass
in
Advanced Prostate Cancer
1 year ago
here we go: JNJ-9414 phase 1
https://www.pharmaceutical-technology.com/data-insights/jnj-9414-johnson-johnson-metastatic-
castration
-resistant-prostate-cancer-mcrpc-likelihood-of-approval/
https://www.pharmaceutical-technology.com/data-insights/jnj-9414-johnson-johnson-metastatic-
castration
-resistant-prostate-cancer-mcrpc-likelihood-of-approval/
Maxone73
in
Advanced Prostate Cancer
27 days ago
ESMO 2023: PSMAfore Phase 3 Trial of [177Lu]Lu-PSMA-617 in Taxane-Naive Patients with Metastatic Castration Resistant Prostate Cancer
Apologies if this was already posted: https://www.urotoday.com/conference-highlights/esmo-2023/esmo-2023-prostate-cancer/147587-esmo-2023-psmafore-phase-3-trial-of-177lu-lu-psma-617-in-taxane-naive-patients-with-mcrpc.html
Apologies if this was already posted: https://www.urotoday.com/conference-highlights/esmo-2023/esmo-2023-prostate-cancer/147587-esmo-2023-psmafore-phase-3-trial-of-177lu-lu-psma-617-in-taxane-naive-patients-with-mcrpc.html
swwags
in
Advanced Prostate Cancer
9 months ago
Here we go.......
One percent of my adult life……Going with Orgovyx over Lupron as it avoids the testosterone spike, reached
castration
level suppression much faster, has less cardiac toxicity and testosterone levels return much more quickly at the termination of therapy.
One percent of my adult life……Going with Orgovyx over Lupron as it avoids the testosterone spike, reached
castration
level suppression much faster, has less cardiac toxicity and testosterone levels return much more quickly at the termination of therapy.
ToolBeltZia
in
Prostate Cancer Network
8 months ago
Oligomets and SBRT: "Whack a Mole"?
Then clinicians will be considering agents approved in the metastatic
castration
sensitive prostate cancer (mCSPC) such as docetaxel, apalutamide, enzalutamide, or abiraterone.
Then clinicians will be considering agents approved in the metastatic
castration
sensitive prostate cancer (mCSPC) such as docetaxel, apalutamide, enzalutamide, or abiraterone.
FrankyB4
in
Advanced Prostate Cancer
10 months ago
Was Chemo "Successful"?
Also my testosterone is virtually undetectable due to
castration
. So it looks like the rise is due at least in part to castrate resistant PC cells.
Also my testosterone is virtually undetectable due to
castration
. So it looks like the rise is due at least in part to castrate resistant PC cells.
spencoid2
in
Advanced Prostate Cancer
11 months ago
New blood test to detect neuroendocrine PCa
Summary: Researchers have developed a blood test that can reliably detect neuroendocrine prostate cancer and differentiate it from
castration
-resistant prostate cancer-adenocarcinoma (CRPC-adeno). https://www.sciencedaily.com/releases/2024/01/240110120221.htm
Summary: Researchers have developed a blood test that can reliably detect neuroendocrine prostate cancer and differentiate it from
castration
-resistant prostate cancer-adenocarcinoma (CRPC-adeno). https://www.sciencedaily.com/releases/2024/01/240110120221.htm
HikerWife
in
Advanced Prostate Cancer
6 months ago
UBX-103: potentially first in class AR degrader
arsi is no longer working (Enza, Daro,…) you still have the option to use this new drug for metastatic prostate cancer https://www.biospace.com/article/releases/ubix-therapeutics-and-yuhan-announce-exclusive-license-agreement-for-ubx-103-an-oral-small-molecule-ar-degrader-for-treatment-of-metastatic-
castration
-resistant-prostate-cancer
arsi is no longer working (Enza, Daro,…) you still have the option to use this new drug for metastatic prostate cancer https://www.biospace.com/article/releases/ubix-therapeutics-and-yuhan-announce-exclusive-license-agreement-for-ubx-103-an-oral-small-molecule-ar-degrader-for-treatment-of-metastatic-
castration
-resistant-prostate-cancer
Maxone73
in
Advanced Prostate Cancer
7 days ago
Slight PSA increase
Any idea if slightly increased PSA could also be a result of treatment (found studies that certain medications can elevate PSA serum level) or this is the first sign of
castration
resistance? Your feedback is very welcomed.
Any idea if slightly increased PSA could also be a result of treatment (found studies that certain medications can elevate PSA serum level) or this is the first sign of
castration
resistance? Your feedback is very welcomed.
Nusch
in
Advanced Prostate Cancer
1 year ago
Phase I/II Trial Evaluation of Radioligand Treatment in Patients with Metastatic Castration-Resistant PCa with [161Tb]Tb-PSMA-I&T
https://www.urotoday.com/recent-abstracts/urologic-oncology/prostate-cancer/153459-clinical-trial-protocol-for-violet-a-single-center-phase-i-ii-trial-evaluation-of-radioligand-treatment-in-patients-with-metastatic-
castration
-resistant-prostate-cancer-with-161tb-tb-psma-i-t.html
https://www.urotoday.com/recent-abstracts/urologic-oncology/prostate-cancer/153459-clinical-trial-protocol-for-violet-a-single-center-phase-i-ii-trial-evaluation-of-radioligand-treatment-in-patients-with-metastatic-
castration
-resistant-prostate-cancer-with-161tb-tb-psma-i-t.html
Maxone73
in
Advanced Prostate Cancer
2 days ago
Phase 1 trial shows promising results for fractionated dose of 225Ac-J591 in PCa treatment
https://www.urotoday.com/conference-highlights/aua-2024/aua-2024-prostate-cancer/151713-aua-2024-phase-i-dose-escalation-trial-of-multiple-and-fractionated-dose-psma-targeted-alpha-radionuclide-225ac-j591-for-metastatic-
castration
-resistant-prostate-cancer.html
https://www.urotoday.com/conference-highlights/aua-2024/aua-2024-prostate-cancer/151713-aua-2024-phase-i-dose-escalation-trial-of-multiple-and-fractionated-dose-psma-targeted-alpha-radionuclide-225ac-j591-for-metastatic-
castration
-resistant-prostate-cancer.html
Maxone73
in
Advanced Prostate Cancer
3 months ago
177Lu-PNT2002 Significantly Improves rPFS Vs ARPI in Metastatic Castration-Resistant Prostate Cancer
https://www.onclive.com/view/177lu-pnt2002-significantly-improves-rpfs-vs-arpi-in-metastatic-
castration
-resistant-prostate-cancer Lutetium seems to be a radiological miracle! Or maybe is the pr2002
https://www.onclive.com/view/177lu-pnt2002-significantly-improves-rpfs-vs-arpi-in-metastatic-
castration
-resistant-prostate-cancer Lutetium seems to be a radiological miracle! Or maybe is the pr2002
Maxone73
in
Advanced Prostate Cancer
7 months ago
AUA 2023: PSA Response and Time-to-Castration Resistance Among Patients with mCSPCa Initiated on Apalutamide, Enzalutamide, or Abiraterone
The objective of this study was to describe a “real-world” experience of mCSPC patients treated with apalutamide, enzalutamide, and abiraterone acetate, with a focus on PSA response and development of
castration
resistance outcomes.
The objective of this study was to describe a “real-world” experience of mCSPC patients treated with apalutamide, enzalutamide, and abiraterone acetate, with a focus on PSA response and development of
castration
resistance outcomes.
skiingfiend
in
Advanced Prostate Cancer
11 months ago
Perineural invasion increases soft tissue progression risk in metastatic castration-resistant prostate cancer post-abiraterone resistance
Patients with PNI showed shorter
castration
-resistant progression free survival (median, 23.73 months vs 25.59 months) and STP progression free survival (median, 19.7 months vs not reached) compared with patients without PNI.
Patients with PNI showed shorter
castration
-resistant progression free survival (median, 23.73 months vs 25.59 months) and STP progression free survival (median, 19.7 months vs not reached) compared with patients without PNI.
God_Loves_Me
in
Advanced Prostate Cancer
2 months ago
Again Actinium 225 - J591 alpha emitter
https://ascopost.com/news/november-2023/metastatic-
castration
-resistant-prostate-cancer-efficacy-of-anti-psma-antibody-with-alpha-emitter/
https://ascopost.com/news/november-2023/metastatic-
castration
-resistant-prostate-cancer-efficacy-of-anti-psma-antibody-with-alpha-emitter/
Maxone73
in
Advanced Prostate Cancer
8 months ago
Clinical trial news
Saruparib (AZD5305) vs Placebo in Men with Metastatic
Castration
-Sensitive Prostate Cancer Receiving Physician's Choice New Hormonal Agents - EvoPAR-PR01 This is looking at whether adding a new drug on top of taking an Androgen Receptor Target Therapy (ARAT; such as abiraterone, darolutamide, enzalutamide
Saruparib (AZD5305) vs Placebo in Men with Metastatic
Castration
-Sensitive Prostate Cancer Receiving Physician's Choice New Hormonal Agents - EvoPAR-PR01 This is looking at whether adding a new drug on top of taking an Androgen Receptor Target Therapy (ARAT; such as abiraterone, darolutamide, enzalutamide
Max24
in
Advanced Prostate Cancer
3 months ago
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