Phase I/II Trial Evaluation of Radioligand Treatment in Patients with Metastatic Castration-Resistant PCa with [161Tb]Tb-PSMA-I&T

[Maxone73]

and it's supposed to do a better job than Lutetium (Pluvicto)

But keep an eye also on 64 Cu SAR Bispsma, which had some incredible results, and of course Actinium....honestly on paper they all seem to be better than Lutetium, well, after all we are evolving...

urotoday.com/recent-abstrac...

[Cenerus]

TB-161 does look really interesting. Unlike Lutetium-177 it gives off high LET auger electrons that can act over short distances that should kill micromets which is the main reason lutetium isn't durable and is just a palliative. It's also much easier to produce than lutetium, so should be cheaper and more plentiful. I'm kind of surprised that it didn't get looked at before lutetium-177 given its better overall performance. If this or Actinium or Astatine finally reach the market, they'll make lutetium obsolete.

[Maxone73 in reply to Cenerus]

I know that there are always exceptiona responders...but here is a gift for you (in case you haven't read about this before): guoncologynow.com/post/comp... 😀

[Cenerus in reply to Maxone73]

I saw that about CU-67. And when you look at CU-67 next to TB-161, the numbers for TB-161 look much more impressive at the level of small volumes down around 5-10 microns where single cells in micrometastasis live.

[Maxone73 in reply to Cenerus]

Even better then!

[rfgaus]

With low SE's and high efficacy to destroy cancer at the cellular level, it would be nice to see these novel Radiogland treatments approved for earlier use in Standard of Care Protocols. Having to go through and fail palliative ADT and Chemo treatments with all their physically destructive SE's to get to something effective is frustrating.

[V10fanatic]

"positive disease on [68Ga]Ga-PSMA-11 or [18F]DCFPyL PET/CT (SUVmax ≥ 20); no sites of discordance on [18F]FDG PET/CT"

Yet another new treatment path that won't work for me

[Maxone73 in reply to V10fanatic]

Why???

[V10fanatic in reply to Maxone73]

My last round of PSMA-PETs came back clear, yet an FDG-PET showed 4 mets.