Hi guys, we talked so much about oral hormones like Casadox, Xtandi, etc. being castration resistant. 1. Can hormone injections like Lupron, Zoladex, etc. be also castration resistant? 2) if Lupron or Zoledex can be castration resistant, how do we know which one — hormonal injections or oral hormones— is castration restriction? 3) let’s say Xtandi I am taking now is no longer effective, if I change to Zoladex from Lupron I am currently using can Xtandi can be effective again ? Appreciate all your responses and thanks.
Hormonal injections and oral hormones - Advanced Prostate...
Hormonal injections and oral hormones
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No! Both deprive cancerous cells from their energy source T. They accomplish this via different paths, but the end result is the same. When the new cells are independent of T castrate resistance sets in. There are two ways to gain extra time. Both are NOT SoC though. First is BAT. You fight the T independent cells by a storm of T and squeeze them by an army of T sensitive cells that can be deactivated later. Second is to use only as much of the medicine as necessary to establish an equilibrium. The hope is that by not overdoing it it will last longer. I am doing it with Bicalutamide user Stoneartist does it with Enzelutamide. Not possible with depot injectable substances. Your call.
1. Yes, of course. Castration resistance means rising PSA or metastases while taking Lupron, Zoladex, etc.
2. If the cancer is castration resistant to a second-line hormonal taken along with Lupron, etc., it is resistant to both.
3. If your cancer is castration resistant, it is resistant to all means of physical or chemical castration, Lupron, Zoladex, orchiectomy, etc. They continue to lower testosterone. But it is more important than ever that you continue to use them. Your cancer has become super-sensitive to even the smallest amount of testosterone.
Thanks Tall Allen. Could you please explain Point 3 again Thanks
What part don't you understand?
“But it is more important than ever that you continue to use them.”
One of the reasons for castration resistance is that the androgen receptor multiplies, so that even the smallest amount of androgen can activate it and cause replication. It is more important than ever to minimize testosterone.
So you are trying to say despite the castration resistance, Lupron or others still has to be administered, right?
Our MO explained that some cancer cells remain sensitive to lower testosterone, they don't all make the jump to castrate resistant at once. Maintaining ADT keeps those cells at bay, which helps the overall situation.
Thank you so much.