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Ranolazine (used for angina) could potentially be repurposed for PCa. Only mouse studies so far.
“Treatment of cancer patients with lipid metabolic inhibitors like ranolazine could potentially re-activate the immune cells to restore and enhance cellular-mediated antitumor immunity and tumor regression.” Targeting Fat Oxidation in Mouse Prostate Cancer Decreases Tumor Growth and Stimulates Anti-Cancer
“Treatment of cancer patients with lipid metabolic inhibitors like ranolazine could potentially re-activate the immune cells to restore and enhance cellular-mediated antitumor immunity and tumor regression.” Targeting Fat Oxidation in Mouse Prostate Cancer Decreases Tumor Growth and Stimulates Anti-Cancer
Graham49
in
Advanced Prostate Cancer
6 months ago
Result of Liver Biopsy - Any Insights?
This is the result of my liver biposy. Any insights on the comment? ----- CLINICAL HISTORY>>:: Prostate Ca with hepatic mets ?Small cell transformation versus other. FINAL DIAGNOSIS>>:: LIVER NODULE, CORE BIOPSY: - POORLY DIFFERENTIATED PROSTATIC ADENOCARCINOMA WITH SMALL CELL TRANSFORMATION
This is the result of my liver biposy. Any insights on the comment? ----- CLINICAL HISTORY>>:: Prostate Ca with hepatic mets ?Small cell transformation versus other. FINAL DIAGNOSIS>>:: LIVER NODULE, CORE BIOPSY: - POORLY DIFFERENTIATED PROSTATIC ADENOCARCINOMA WITH SMALL CELL TRANSFORMATION
skiingfiend
in
Advanced Prostate Cancer
6 months ago
brachytherapy
my hubbie has just had brachytherapy for stage 3 prostate and has been in great pain since Thursday. He’s been told it’s normal and to suck it up but he’s not sleeping and is struggling to wee without great pain (tears) . Any advice as to what has worked for you to manage post op brachytherapy please
my hubbie has just had brachytherapy for stage 3 prostate and has been in great pain since Thursday. He’s been told it’s normal and to suck it up but he’s not sleeping and is struggling to wee without great pain (tears) . Any advice as to what has worked for you to manage post op brachytherapy please
bikebabe
in
Prostate Cancer Network
6 months ago
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High Testosterone Level Why?
It is nearly 2'years since I was admitted to hospital to discover I had decompensated liver disease. Now I am compensated with very good bloods, no meds, and healthy. except my testosterone level . It is constantly high around 40 nmol or approx 1135 :ng/dl .( Has been higher ) I'm 62 male and as
It is nearly 2'years since I was admitted to hospital to discover I had decompensated liver disease. Now I am compensated with very good bloods, no meds, and healthy. except my testosterone level . It is constantly high around 40 nmol or approx 1135 :ng/dl .( Has been higher ) I'm 62 male and as
Taffypaul
in
British Liver Trust
6 months ago
Now been advised cancer has spread to both lungs 😔
Spoke to my consultant yesterday, it seems my nurse specialist had not given me the correct information. Cancer signs are now on both lungs, in my peritoneal area, and under my spleen (not the spleen itself). I am getting some pain in my lung area and it's really worrying me 😔 Surgery is still
Spoke to my consultant yesterday, it seems my nurse specialist had not given me the correct information. Cancer signs are now on both lungs, in my peritoneal area, and under my spleen (not the spleen itself). I am getting some pain in my lung area and it's really worrying me 😔 Surgery is still
Kazzh
in
My Ovacome
6 months ago
Zometa
Insurance denied my Xgeva shot . Was told I had to do Zometa. Looking at the potential side effects ( stomach) Im not inclined. Been dealing with ibs and gerd for years and not really wanting to go with anything that will increase that situation. I've read that Zometa does nothing to prevent SRE events
Insurance denied my Xgeva shot . Was told I had to do Zometa. Looking at the potential side effects ( stomach) Im not inclined. Been dealing with ibs and gerd for years and not really wanting to go with anything that will increase that situation. I've read that Zometa does nothing to prevent SRE events
APK3
in
Advanced Prostate Cancer
6 months ago
The Results are in
Hello wonderful people. Just a quick update as I am so relieved I had to tell you. I have just put the phone down from my fabulous ENT Consultant. She had just received the results of the mass from the lab and wanted to tell me the good news. No cancer but an haemangioma. She confided that she had really
Hello wonderful people. Just a quick update as I am so relieved I had to tell you. I have just put the phone down from my fabulous ENT Consultant. She had just received the results of the mass from the lab and wanted to tell me the good news. No cancer but an haemangioma. She confided that she had really
CecilyParsley
in
LUPUS UK
6 months ago
AUS revision surgery?
I'm seeking advice on having a second AUS surgery. My background: I had a prostatectomy in 2016 and radiation a year later because the cancerous tumor had penetrated the sack. I have since had undetected PSA but have suffered with severe stress incontinence. I had AUS surgery in 2018 but it failed because
I'm seeking advice on having a second AUS surgery. My background: I had a prostatectomy in 2016 and radiation a year later because the cancerous tumor had penetrated the sack. I have since had undetected PSA but have suffered with severe stress incontinence. I had AUS surgery in 2018 but it failed because
allnewstuff
in
Advanced Prostate Cancer
6 months ago
Feasibility of someone from out of USA joining a clinical trial in USA?
My father has Prostate cancer (stage IV) and High Grade Neuro-endocrine cancer / Small Cell Carcinoma in liver. His six doses of Chemotherapy (carboplatin + etoposide) that ended seven weeks earlier. My understanding is that chemotherapy is the established regimen for High Grade NE Cancer/SCC. Are
My father has Prostate cancer (stage IV) and High Grade Neuro-endocrine cancer / Small Cell Carcinoma in liver. His six doses of Chemotherapy (carboplatin + etoposide) that ended seven weeks earlier. My understanding is that chemotherapy is the established regimen for High Grade NE Cancer/SCC. Are
RindaMan
in
Advanced Prostate Cancer
6 months ago
Nano Knife Surgery
I recently underwent a brand new surgical procedure called nano knife. Dr. Mayank Patel in Encino California, a da Vinci robotic and TULSA pro expert surgeon recommended this procedure after a panel of doctors examined my MRI and CT scans. The procedure was successful and five months post surgery
I recently underwent a brand new surgical procedure called nano knife. Dr. Mayank Patel in Encino California, a da Vinci robotic and TULSA pro expert surgeon recommended this procedure after a panel of doctors examined my MRI and CT scans. The procedure was successful and five months post surgery
HangIn66
in
Prostate Cancer Network
6 months ago
Moving on to hospice care
many of you have heard from me before at this point. My dad (68, diagnosed almost 2 years ago) had his last appointment with his MO two weeks ago or so. Radium 223 is out of the picture for him as he is just not well and it would not aid his survival at this point. They suggested some radiation for the
many of you have heard from me before at this point. My dad (68, diagnosed almost 2 years ago) had his last appointment with his MO two weeks ago or so. Radium 223 is out of the picture for him as he is just not well and it would not aid his survival at this point. They suggested some radiation for the
StayingSTRNG
in
Advanced Prostate Cancer
6 months ago
Next Steps
My brother was dDiagnosed in March 2023 with widespread prostate cancer metastasized to the spine, pelvic bones, ribs both left and right, and skull and lymph nodes. No progression to any organs. He had a orchiectomy, is on ABIRATERONE 500MG and has just completed six treatments of Doxetaxel .
My brother was dDiagnosed in March 2023 with widespread prostate cancer metastasized to the spine, pelvic bones, ribs both left and right, and skull and lymph nodes. No progression to any organs. He had a orchiectomy, is on ABIRATERONE 500MG and has just completed six treatments of Doxetaxel .
Sparlingo
in
Advanced Prostate Cancer
6 months ago
Prostate Biopsy / Ibrutinib
I am on Ibrutinib for my CLL. Do I stop taking my Ibrutinib for a few days prior and after the biopsy? Thank you.
I am on Ibrutinib for my CLL. Do I stop taking my Ibrutinib for a few days prior and after the biopsy? Thank you.
Dyba
in
CLL Support
6 months ago
First Post for husband and need advice please
This is our basic history. We have appt. with RO tomorrow to talk about next steps. Any advice and questions to ask is much appreciated. PSA- 12/2020 3.3 - 11/2021 4.83 - 04/2022 5.3 Biopsy-06/22- Gleason 3+4, RARP-09/26/2022, Pathology, JH -pT3apN1pM Gleason 3+4 grade 2, 20% pattern 4 of dominant
This is our basic history. We have appt. with RO tomorrow to talk about next steps. Any advice and questions to ask is much appreciated. PSA- 12/2020 3.3 - 11/2021 4.83 - 04/2022 5.3 Biopsy-06/22- Gleason 3+4, RARP-09/26/2022, Pathology, JH -pT3apN1pM Gleason 3+4 grade 2, 20% pattern 4 of dominant
MikeLa08
in
Prostate Cancer Network
6 months ago
radiation or no radiation
I Just updated my profile and am G-9 with PNI, IDC and lymphovascular invasion. Check 2 mutation as well but Decipher at .41. RP Dr V Patel march 2020 (T3b, negative margins and negative lymph nodes) and PSA undetectable until Sept 2023. Started at 0.021 and now Feb 22nd 2024 at 0.052. Seeing Dr
I Just updated my profile and am G-9 with PNI, IDC and lymphovascular invasion. Check 2 mutation as well but Decipher at .41. RP Dr V Patel march 2020 (T3b, negative margins and negative lymph nodes) and PSA undetectable until Sept 2023. Started at 0.021 and now Feb 22nd 2024 at 0.052. Seeing Dr
Peppertree602
in
Advanced Prostate Cancer
6 months ago
Dustasteride (avodart)
My doc has prescribed this drug for benign prostatic hyperplasia. I need help with urinary frequency, urgency, and frequent night time urination. It is too early to tell if the drug is helping. It can three to six months to have the desired effect of reducing prostate swelling. I am posting because
My doc has prescribed this drug for benign prostatic hyperplasia. I need help with urinary frequency, urgency, and frequent night time urination. It is too early to tell if the drug is helping. It can three to six months to have the desired effect of reducing prostate swelling. I am posting because
Parrsboro
in
Sensitive Issues for Men
6 months ago
Allergic reaction to Doxil, my first ever chemo infusion
Hi everyone, Has anyone experienced an allergic reaction to Doxil? Almost three years ago, I was diagnosed with stage 4 MBC. After being on hormone therapy for over two years, mostly IBrance and Letrozole, and then oral chemo for six months, my most recent petscan showed the cancer is still spreading
Hi everyone, Has anyone experienced an allergic reaction to Doxil? Almost three years ago, I was diagnosed with stage 4 MBC. After being on hormone therapy for over two years, mostly IBrance and Letrozole, and then oral chemo for six months, my most recent petscan showed the cancer is still spreading
penpen18
in
SHARE Metastatic Breast Cancer
6 months ago
infusion Side Effects
good morning fellow warriors. My PSA continues to move up so my oncologist ordered 20 sessions of radiation. The radiation was a walk in the park compared to the 1030-1048 Zometa infused Wednesday morning. Holy cow ! Peed (a few dribbles) every half hour. Chills then sweats. Bone ache throughout and
good morning fellow warriors. My PSA continues to move up so my oncologist ordered 20 sessions of radiation. The radiation was a walk in the park compared to the 1030-1048 Zometa infused Wednesday morning. Holy cow ! Peed (a few dribbles) every half hour. Chills then sweats. Bone ache throughout and
3putt
in
Advanced Prostate Cancer
6 months ago
Doing well on Taxol. TM down by half!
I'm a long timer (20 years on 3/1/24, with bone mets since first diagnosis) and have done extremely well. Lobular bc, E + P + her2neu - at diagnosis. In 2023, it became triple negative and I was on Xeloda for a few months. It stopped working and I've been on Taxol for about 5 or 6 infusions. CA 27
I'm a long timer (20 years on 3/1/24, with bone mets since first diagnosis) and have done extremely well. Lobular bc, E + P + her2neu - at diagnosis. In 2023, it became triple negative and I was on Xeloda for a few months. It stopped working and I've been on Taxol for about 5 or 6 infusions. CA 27
PJBinMI
in
SHARE Metastatic Breast Cancer
6 months ago
New to the form
hello, My mum sent me this information with the hopes that I can find support and information as I’m starting out my journey. I had been having irregular periods and lower back pain for a few months. I would take medication and just push on. In December, I had such severe pain I called my husband
hello, My mum sent me this information with the hopes that I can find support and information as I’m starting out my journey. I had been having irregular periods and lower back pain for a few months. I would take medication and just push on. In December, I had such severe pain I called my husband
Trixie-boo
in
My Ovacome
6 months ago
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