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Vitamin D metabolism in cancer: potential feasibility of vitamin D metabolism blocking therapy
New paper below [1]. Vitamin D circulates in the blood as inactive 25-D. The kidneys will convert 25-D to the active hormone 1,25-D, as needed, to maintain circulating calcium levels. Elsewhere, cells that need 1,25-D first produce the enzyme that performs the conversion of 25-D. It is normal for
New paper below [1]. Vitamin D circulates in the blood as inactive 25-D. The kidneys will convert 25-D to the active hormone 1,25-D, as needed, to maintain circulating calcium levels. Elsewhere, cells that need 1,25-D first produce the enzyme that performs the conversion of 25-D. It is normal for
pjoshea13
in
Fight Prostate Cancer
1 year ago
Collagen Peptide supplements and bone quality
Y'all are familiar by now that ADT leads to accelerated BMD (bone mineral density) loss. There are a series of things that can be done -- 1, Get a DEX scan now 2, Supplement with Calcium, K2, D3 and magnesium 3, Have your MO or whoever put you on BMD medication (eg denosumab, et al) Now comes
Y'all are familiar by now that ADT leads to accelerated BMD (bone mineral density) loss. There are a series of things that can be done -- 1, Get a DEX scan now 2, Supplement with Calcium, K2, D3 and magnesium 3, Have your MO or whoever put you on BMD medication (eg denosumab, et al) Now comes
Derf4223
in
Advanced Prostate Cancer
1 year ago
Groundhog Year
Another year passes and the annual blood test causes its usual issues. I did get retested because of an abnormal result serum calcium concentration 2.19 mmol/L (2.20-2.60) They did the test uncuffed and I crept into range. TSH <0.01miu/L (0.49 - 5.23) like this since starting Liothyronine in
Another year passes and the annual blood test causes its usual issues. I did get retested because of an abnormal result serum calcium concentration 2.19 mmol/L (2.20-2.60) They did the test uncuffed and I crept into range. TSH <0.01miu/L (0.49 - 5.23) like this since starting Liothyronine in
tzracer
in
Thyroid UK
1 year ago
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Update and Advice please
Happy Monday everyone. Please can I ask for more advice from this wonderful group. So I started on the 75 Levo on the 19 January. 50 (Accord) 25(Teva). My first few days on the extra 25 Levo I had bad headaches. Still having them but they are manageable. My moods have got much better over the weeks
Happy Monday everyone. Please can I ask for more advice from this wonderful group. So I started on the 75 Levo on the 19 January. 50 (Accord) 25(Teva). My first few days on the extra 25 Levo I had bad headaches. Still having them but they are manageable. My moods have got much better over the weeks
Pooty
in
Thyroid UK
1 year ago
Update 7.4
Just met with my regular hematologist for a follow up. The CBC looks good, with HCT dropping a bit more to 43.0%. All the other numbers look good. We will carry on with the current plan, Besremi 150mcg and monitor labs every 8 weeks. I am very pleased that the three more doses of Besremi + a single
Just met with my regular hematologist for a follow up. The CBC looks good, with HCT dropping a bit more to 43.0%. All the other numbers look good. We will carry on with the current plan, Besremi 150mcg and monitor labs every 8 weeks. I am very pleased that the three more doses of Besremi + a single
hunter5582
in
MPN Voice
1 year ago
Calcium and other bone needs
Decided not to take the 500 g of calcium built into the triple pill containing K2 and D3. It was also a huge pill which is off putting. I’ve purchased the K2 and D3 combination but picked a separate one for the calcium which contains 250 g. Good thing is it has other goodies included like manganese and
Decided not to take the 500 g of calcium built into the triple pill containing K2 and D3. It was also a huge pill which is off putting. I’ve purchased the K2 and D3 combination but picked a separate one for the calcium which contains 250 g. Good thing is it has other goodies included like manganese and
MWZ3
in
Bone Health and Osteoporosis UK
1 year ago
Does anyone take NDT at night?
Hi I’m thinking about swapping my meds to nighttime. I currently take a combination of ERFA and thyroxine first thing, and then another 1/2 grain of ERFA at lunch. But my calcium is very low and I need to take multiple doses at the moment which is tricky with thyroid meds. So I’ve been thinking
Hi I’m thinking about swapping my meds to nighttime. I currently take a combination of ERFA and thyroxine first thing, and then another 1/2 grain of ERFA at lunch. But my calcium is very low and I need to take multiple doses at the moment which is tricky with thyroid meds. So I’ve been thinking
Spangle15
in
Thyroid UK
1 year ago
Do you think ivf treatment abroad is better and why?
Hi everyone, I would like to get some advice regarding treatments abroad, please. We are with a great private clinic in London, but our last attempt was disastrous. Would you please be able to share your treatment plan or protocol and how it was different from the one received here in Uk? According
Hi everyone, I would like to get some advice regarding treatments abroad, please. We are with a great private clinic in London, but our last attempt was disastrous. Would you please be able to share your treatment plan or protocol and how it was different from the one received here in Uk? According
ourbundleofjoy
in
Fertility Network UK
1 year ago
Advice about monitor my health results please.
Hello everyone, Just a brief history first.Diagnosed with graves disease and TED in 2018.Tried titration and block and replace for 4 years.Chose to have a total thyroidectomy in June 2022.Been feeling well and having no problems, apart from low calcium which looks to have resolved itself( one more blood
Hello everyone, Just a brief history first.Diagnosed with graves disease and TED in 2018.Tried titration and block and replace for 4 years.Chose to have a total thyroidectomy in June 2022.Been feeling well and having no problems, apart from low calcium which looks to have resolved itself( one more blood
Cavapoochonowner
in
Thyroid UK
1 year ago
just been prescribed AA & Adcal D3?
a big shout out to all you wonderful people. Diag early Oct 2022 with GCA, started on 40mg, now on 15mg. Had my Rheumy follow up appt a couple of weeks ago where she seems to have passed me back to my GP to continue the pred. I had a tele appt a week ago with GP and she has prescribed some more pred
a big shout out to all you wonderful people. Diag early Oct 2022 with GCA, started on 40mg, now on 15mg. Had my Rheumy follow up appt a couple of weeks ago where she seems to have passed me back to my GP to continue the pred. I had a tele appt a week ago with GP and she has prescribed some more pred
Cfmad298601
in
PMRGCAuk
1 year ago
calcium deposit on my face
calcium deposits
calcium deposits
bobst
in
Scleroderma & Raynaud's UK (SRUK)
1 year ago
BONE HELP
I have done so many hours of research on osteoporosis drugs and the natural route. Our bodies fight anything you put into your body that is not of natural substance. Too many people have had terrible results from all these prescriptions. Doctors do not have the time to stay up with research on these
I have done so many hours of research on osteoporosis drugs and the natural route. Our bodies fight anything you put into your body that is not of natural substance. Too many people have had terrible results from all these prescriptions. Doctors do not have the time to stay up with research on these
TWEETYCAT
in
Osteoporosis Support
1 year ago
Third Update, Triple Threat and still no Buzzards Above. Now, why Ibrance?
HEART: The message from the heart surgeon at Columbia PresbyterianHospital is that although the aortic heart valve is thick with calcium and has stenosis, the opening has not got small enough for surgery. So, I will have to be monitored and wait till I get sick enough for surgery. No time frame is given
HEART: The message from the heart surgeon at Columbia PresbyterianHospital is that although the aortic heart valve is thick with calcium and has stenosis, the opening has not got small enough for surgery. So, I will have to be monitored and wait till I get sick enough for surgery. No time frame is given
jersey-jazz
in
SHARE Metastatic Breast Cancer
1 year ago
Roller Coaster Ride
I haven’t been very present in the group this last week. It’s been a very up and down time. Briefly I’ve had an awful time, feeling confused, exhausted and abandoned. One doctor on a telephone call upped my pred dose from 15 to 30, increased my painkillers for the better. After several bad nights both
I haven’t been very present in the group this last week. It’s been a very up and down time. Briefly I’ve had an awful time, feeling confused, exhausted and abandoned. One doctor on a telephone call upped my pred dose from 15 to 30, increased my painkillers for the better. After several bad nights both
BigEric
in
PMRGCAuk
1 year ago
Valium RLS
Is anyone using Valium/diazepam or any other benzo to treat RLS? The Horizant that I’ve been using for the last year and a half isn’t working as well as it used to.
Is anyone using Valium/diazepam or any other benzo to treat RLS? The Horizant that I’ve been using for the last year and a half isn’t working as well as it used to.
tagaxel
in
Restless Legs Syndrome
1 year ago
Calcium citrate
I can’t take calcium carbonate so take this instead but I’m having trouble finding it in a tablet/capsule size I can easily swallow. Citracal Petites are recommended but I can’t find anywhere that sells them in the UK that doesn’t have dreadful reviews on Trustpilot. Any recommendations?
I can’t take calcium carbonate so take this instead but I’m having trouble finding it in a tablet/capsule size I can easily swallow. Citracal Petites are recommended but I can’t find anywhere that sells them in the UK that doesn’t have dreadful reviews on Trustpilot. Any recommendations?
Nuthatch
in
Bone Health and Osteoporosis UK
1 year ago
FET prep
Sorry for the long post. i started my fertility journey last year in October after being on folic acid, Menopur75 mg *3, Duphaston and then decapeptyl 36hrs before the egg collection (nov 3) 2 matured eggs fertilised and only 1 made it to day 6 blast. It is a 3BB and when I went for my scan the following
Sorry for the long post. i started my fertility journey last year in October after being on folic acid, Menopur75 mg *3, Duphaston and then decapeptyl 36hrs before the egg collection (nov 3) 2 matured eggs fertilised and only 1 made it to day 6 blast. It is a 3BB and when I went for my scan the following
KediT
in
Fertility Network UK
1 year ago
Abdominal MRI
good morning. I’m curious for those who have had an MRI, did you have to take something for anxiety? My hep has suggested Valium but I prefer not to be loop legged.
good morning. I’m curious for those who have had an MRI, did you have to take something for anxiety? My hep has suggested Valium but I prefer not to be loop legged.
gwillistexas
in
PBC Foundation
1 year ago
AFIB, Besremi refused by insurance, and more
On December 1, I felt breathless, climbing stairs quickly and caring for my husband (who had open heart surgery in November). I felt like my heart was beating fast, and I was winded. But it got worse: My apple watch said I was in AFIB. AFIB??? I have no heart issues. I went to the emergency room
On December 1, I felt breathless, climbing stairs quickly and caring for my husband (who had open heart surgery in November). I felt like my heart was beating fast, and I was winded. But it got worse: My apple watch said I was in AFIB. AFIB??? I have no heart issues. I went to the emergency room
Elizka
in
MPN Voice
1 year ago
Update 7.3 Good news this time
My HCT had been creeping up over time as my iron levels improved. 12/19 HCT=47.9% and HGB=15.5. Since it was now consistently above target for PV, time to do something. Unfortunately, the liver enzymes were close to 3x/upper limit of normal ALT=157, AST=94.0, ALP=211. We were all in agreement that
My HCT had been creeping up over time as my iron levels improved. 12/19 HCT=47.9% and HGB=15.5. Since it was now consistently above target for PV, time to do something. Unfortunately, the liver enzymes were close to 3x/upper limit of normal ALT=157, AST=94.0, ALP=211. We were all in agreement that
hunter5582
in
MPN Voice
1 year ago
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