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Epigenetic therapy (decitabine) shows promise for endocrine-resistant breast cancer
Using a low dose of the epigenetic therapy drug decitabine, which is currently used to treat some blood cancers, the researchers significantly suppressed the growth of endocrine resistant breast tumours in mice and increased survival time by 90%. The finding, which will be tested in a future Phase I
Using a low dose of the epigenetic therapy drug decitabine, which is currently used to treat some blood cancers, the researchers significantly suppressed the growth of endocrine resistant breast tumours in mice and increased survival time by 90%. The finding, which will be tested in a future Phase I
Split
in
SHARE Metastatic Breast Cancer
6 months ago
results comparison - question around conversion…
hi there I have posted a few times in the past - more recently about my private dr suggesting T3 medication route. After getting advice on her I decided not to pursue that at this time and instead titrate my T4 / Levo up a step (from 50mcg to 75mcg daily) - have just done blood test after 8 weeks
hi there I have posted a few times in the past - more recently about my private dr suggesting T3 medication route. After getting advice on her I decided not to pursue that at this time and instead titrate my T4 / Levo up a step (from 50mcg to 75mcg daily) - have just done blood test after 8 weeks
Gosierunn
in
Thyroid UK
21 days ago
My introduction Hi
Hiya everyone. Here, as I have recently, by accident really, been to the doctor to see if I might qualify for weight loss drugs, having heard such good things about ozempic or the tablet version Rybelsus. Dr said no, I don't qualify for it. But BP was 185/172 which shows hypertensive crisis, heading
Hiya everyone. Here, as I have recently, by accident really, been to the doctor to see if I might qualify for weight loss drugs, having heard such good things about ozempic or the tablet version Rybelsus. Dr said no, I don't qualify for it. But BP was 185/172 which shows hypertensive crisis, heading
Halcyondaze
in
British Liver Trust
21 days ago
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Update
Hi following on from my post 2 months ago when my GP reduced my carbinmazole dose to 10mg daily as my levels had changed to hypothyroidismHere are the results of my latest blood test 4th June 2024TSH 0.01 T4 37.2 Serum free triidothyrimine 13.6 My T4 levels have never been this high but I'm hoping
Hi following on from my post 2 months ago when my GP reduced my carbinmazole dose to 10mg daily as my levels had changed to hypothyroidismHere are the results of my latest blood test 4th June 2024TSH 0.01 T4 37.2 Serum free triidothyrimine 13.6 My T4 levels have never been this high but I'm hoping
Maccao
in
Thyroid UK
21 days ago
Lft test confusion
Hi, Not my test but my brothers for family court.He's passed all his hair tests and blood tests. He's had issues with drink but has slowed down to mainly binge drinking for the last few years. He last had spirits 3 weeks before the tests were taken, his cdt came back within range at 1.4 however his lft
Hi, Not my test but my brothers for family court.He's passed all his hair tests and blood tests. He's had issues with drink but has slowed down to mainly binge drinking for the last few years. He last had spirits 3 weeks before the tests were taken, his cdt came back within range at 1.4 however his lft
Dolly101010
in
British Liver Trust
21 days ago
lost my brother to SADS
Hello, I recently lost my brother at Christmas, he was only 30 years old and was fit, active and health. Was studying at university to become a physiotherapist and had his whole life ahead of him. We recently got his cause of death which was due to SADS. I’m due to go for genetic testing and have
Hello, I recently lost my brother at Christmas, he was only 30 years old and was fit, active and health. Was studying at university to become a physiotherapist and had his whole life ahead of him. We recently got his cause of death which was due to SADS. I’m due to go for genetic testing and have
MeganR13
in
British Heart Foundation
21 days ago
niraparib
Hi everyone. I have sought your wonderful advices before so I hope you can help me again. My daughter is having trouble tolerating niraparib. Her haemoglobin is very low. She has had one blood transfusion (2 units) four weeks ago and halved her Niraparib from 200 to 100. Her bloods are still
Hi everyone. I have sought your wonderful advices before so I hope you can help me again. My daughter is having trouble tolerating niraparib. Her haemoglobin is very low. She has had one blood transfusion (2 units) four weeks ago and halved her Niraparib from 200 to 100. Her bloods are still
BrandyHorse
in
My Ovacome
21 days ago
Anyone had a symptom dip after upping levo or changing tablet size?
After my elated post which I was finally upped to 75mg and all the pain I had vanished and energy & brain fog improved, I have taken a dip. Just wondering if anyone had experienced this? Upped 75mcg from 50mcg end of March and had been feeling brilliant until 25th May. What's interesting is this
After my elated post which I was finally upped to 75mg and all the pain I had vanished and energy & brain fog improved, I have taken a dip. Just wondering if anyone had experienced this? Upped 75mcg from 50mcg end of March and had been feeling brilliant until 25th May. What's interesting is this
CherryPie2
in
Thyroid UK
21 days ago
Giving levo another go...
Hi thyroid community, I have been diagnosed with 'sub clinical' hypothyroidism (due to autoimmune condition) in the last few years and my life has been shit ever since as I'm sure many can relate. I didn't get on very well with levothyroxine during my first trial, but I decided to persist giving it
Hi thyroid community, I have been diagnosed with 'sub clinical' hypothyroidism (due to autoimmune condition) in the last few years and my life has been shit ever since as I'm sure many can relate. I didn't get on very well with levothyroxine during my first trial, but I decided to persist giving it
rainbowcabbage
in
Thyroid UK
21 days ago
Very high cholesterol is it linked to an under active Thyroid?
I have asked for a blood test and it's come out at 9,5. I have been getting palpitations lately they hay checked my Thyroid and my levels are fine. I am just concerned because I can't understand why it is so high. I know I'm over weight but I don't have a high fat diet and I walk between 3 and 4 miles
I have asked for a blood test and it's come out at 9,5. I have been getting palpitations lately they hay checked my Thyroid and my levels are fine. I am just concerned because I can't understand why it is so high. I know I'm over weight but I don't have a high fat diet and I walk between 3 and 4 miles
Kathy6
in
Thyroid UK
21 days ago
Indapamide & Potassium
Hi guys, i had a blood test on Monday as doctor wanted to test U&Es. Was born with one kidney & have high blood pressure also underactive thyroid Serum sodium level 135 mmol/L [133.0 - 146.0] Serum potassium level 3.5 mmol/L [3.5 - 5.3] Serum urea level 3.2 mmol/L [2.5 - 7.8] Serum creatinine level 74
Hi guys, i had a blood test on Monday as doctor wanted to test U&Es. Was born with one kidney & have high blood pressure also underactive thyroid Serum sodium level 135 mmol/L [133.0 - 146.0] Serum potassium level 3.5 mmol/L [3.5 - 5.3] Serum urea level 3.2 mmol/L [2.5 - 7.8] Serum creatinine level 74
yewotc23
in
Thyroid UK
21 days ago
Indapamide & Potassium
Hi guys, i had a blood test on Monday to as doctor wanted to test U&Es. Was born with one kidney & have high blood pressure Serum sodium level 135 mmol/L [133.0 - 146.0] Serum potassium level 3.5 mmol/L [3.5 - 5.3] Serum urea level 3.2 mmol/L [2.5 - 7.8] Serum creatinine level 74 umol/L [45.0 - 84.0
Hi guys, i had a blood test on Monday to as doctor wanted to test U&Es. Was born with one kidney & have high blood pressure Serum sodium level 135 mmol/L [133.0 - 146.0] Serum potassium level 3.5 mmol/L [3.5 - 5.3] Serum urea level 3.2 mmol/L [2.5 - 7.8] Serum creatinine level 74 umol/L [45.0 - 84.0
yewotc23
in
Early CKD Support
21 days ago
Indapamide & Potassium
Hi guys, i had a blood test on Monday to as doctor wanted to test U&Es Serum sodium level 135 mmol/L [133.0 - 146.0] Serum potassium level 3.5 mmol/L [3.5 - 5.3] Serum urea level 3.2 mmol/L [2.5 - 7.8] Serum creatinine level 74 umol/L [45.0 - 84.0] It's been marked as satisfactory no further action,
Hi guys, i had a blood test on Monday to as doctor wanted to test U&Es Serum sodium level 135 mmol/L [133.0 - 146.0] Serum potassium level 3.5 mmol/L [3.5 - 5.3] Serum urea level 3.2 mmol/L [2.5 - 7.8] Serum creatinine level 74 umol/L [45.0 - 84.0] It's been marked as satisfactory no further action,
yewotc23
in
High Blood Pressure Support
21 days ago
urgent help with T3 problem
I started taking T3 13 weeks ago from a private endo. I increased it gradually and am currently on 10mcg twice per day and lowered my levo from 175mg to 150mg. My problem is I actually feel worse than I did before! My last blood test showed that my T3 levels had gone up but could be better but I feel
I started taking T3 13 weeks ago from a private endo. I increased it gradually and am currently on 10mcg twice per day and lowered my levo from 175mg to 150mg. My problem is I actually feel worse than I did before! My last blood test showed that my T3 levels had gone up but could be better but I feel
sugarlove1
in
Thyroid UK
21 days ago
Heart Attack- 1 year review of medication
Good Morning, It will be coming up to a year soon of having my HA & Stent fitting. I will get a review of all medication I currently take, I would like not to be on any! But I feel anxiety of coming off them and having another HA. I guess this is normal. I’m just looking for any advice or your experience
Good Morning, It will be coming up to a year soon of having my HA & Stent fitting. I will get a review of all medication I currently take, I would like not to be on any! But I feel anxiety of coming off them and having another HA. I guess this is normal. I’m just looking for any advice or your experience
Hjb83
in
British Heart Foundation
21 days ago
still anxious about pancreatic cancer
hey, so I've been told I have Gilbert syndrome as although my bloods have shown elevated bilirubin (23 u/mol and then 2nd blood test 32 u/mol) my liver function is fine, I have also had a clear ultrasound. have been having middle to upper back ache on and off for months and I'm now worried again that
hey, so I've been told I have Gilbert syndrome as although my bloods have shown elevated bilirubin (23 u/mol and then 2nd blood test 32 u/mol) my liver function is fine, I have also had a clear ultrasound. have been having middle to upper back ache on and off for months and I'm now worried again that
Megaaalee
in
British Liver Trust
21 days ago
Pain under right rib following increased levothyroxine dose
I started levothyroxine 3 months ago at 50mg following a slightly high TSH count resulting in an ultrasound which found a benign thyroid nodule. My TSH was good for the first following up, but raised above the threshold in my last blood test. My last test also showed high cholesterol. So, I had my levo
I started levothyroxine 3 months ago at 50mg following a slightly high TSH count resulting in an ultrasound which found a benign thyroid nodule. My TSH was good for the first following up, but raised above the threshold in my last blood test. My last test also showed high cholesterol. So, I had my levo
sarahmlawton
in
Thyroid UK
22 days ago
I just popped this on Thyroid Uk but thought I would lift your day too.
I sure did put the cat amongst the pigeons with my letter to my endocrinologist. I just recieved this email from my surgery.......... Thank you for discussing your concerns today. I am sorry we were not able to provide the timely care you indicated you needed on the phone. As next steps we will: -
I sure did put the cat amongst the pigeons with my letter to my endocrinologist. I just recieved this email from my surgery.......... Thank you for discussing your concerns today. I am sorry we were not able to provide the timely care you indicated you needed on the phone. As next steps we will: -
Jillymo
in
Pernicious Anaemia Society
22 days ago
Just to lift your day...... 😂
I sure did put the cat amongst the pigeons with my letter to my endocrinologist, I just recieved this email from my surgery.......... Thank you for discussing your concerns today. I am sorry we were not able to provide the timely care you indicated you needed on the phone. As next steps we will:
I sure did put the cat amongst the pigeons with my letter to my endocrinologist, I just recieved this email from my surgery.......... Thank you for discussing your concerns today. I am sorry we were not able to provide the timely care you indicated you needed on the phone. As next steps we will:
Jillymo
in
Thyroid UK
22 days ago
B12 deficiency and night sweats query
Hi - I don't have a diagnosis but I hope you don't mind if I pick your expert brains 🙏 I (Female, 45) have fairly regular blood tests due to medication I take for inflammatory arthritis. My MCV has been a little bit high for years (up to 102). Early on doctors would question it and because of a family
Hi - I don't have a diagnosis but I hope you don't mind if I pick your expert brains 🙏 I (Female, 45) have fairly regular blood tests due to medication I take for inflammatory arthritis. My MCV has been a little bit high for years (up to 102). Early on doctors would question it and because of a family
rmros
in
Pernicious Anaemia Society
22 days ago
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