My wife was borderline cushing's disease back in fall. For years she had a nodule on her adrenal gland that was creating significant health issues. Had surgery to remove the one gland back in November, and then was on a course of hydrocortisone for about 4 months (gradually decreasing dosage until done). At her recent bloodtest, it shows that the BUN - which has always been in the normal range - went from 18 in early January to 35 by end of January, with the most recent blood test being 39. We were shocked to see a diagnosis of CKD3 on her recent results, being that it was never discussed before. What happened to stage 1 and 2 ?! Bloodwork was done in preparation for hernia surgery in a few weeks, so the doctor told me that she needed to list all possible diseases, etc. for the pre-surgery. I was also told that kidney disease "was already on her chart". I looked back and prior visits and not a thing is mentioned.
Her creatinine - which also was always normal - went from .78 in early January to .94 by the end of the month, and now is 1.09.
Likewise, eGFR - also always normal - was 82 beginning of Jan. and 66 by the end, and now 55.
My suspicion is that the whole adrenal issue really is a probably link. I consulted with her endocrinologist and he indicates that taking the cortef would not cause kidney damage. So I guess the big question is - is there actual impairment or are we seeing weird numbers that have been generated as a result of whatever the adrenal / hydrocortisone issue caused. Her GP, at this point, doesn't seem all that concerned and simply says they should keep monitoring her bloodwork. BP at the recent visit last week was 126/82 -and has been around that range. All her other bloodwork is normal.
How concerned should we be with all this? We need to get through the hernia surgery first, and then we can address the kidneys. I have read some things that point to adrenal issues affecting kidney function, so have to wonder if we fixed one issue only to create another! The adrenalectomy had to be done. Following that November surgery, there were also some severe UTIs for which she was hospitalized in December. A referral was given to see a urologist but then we never followed up on it since everything resolved after two rounds of antibiotics.
Any advice or helpful feedback appreciated.
Best,
Keith