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Length of Treatment for Orgovyx (Relugolix) versus Lupron and other Longer Acting ADT drugs as Adjuvant to RT or Used for IADT?
I'm curious if anyone has had any discussion with their MO or Radiation Oncologist about having to take a longer course of Orgovyx compared to Lupron or other longer acting ADT drugs because Testosterone comes back so much quicker on Orgovyx? It would seem to me, 6 months of Orgovyx is like the equivalent
I'm curious if anyone has had any discussion with their MO or Radiation Oncologist about having to take a longer course of Orgovyx compared to Lupron or other longer acting ADT drugs because Testosterone comes back so much quicker on Orgovyx? It would seem to me, 6 months of Orgovyx is like the equivalent
jazj
in
Advanced Prostate Cancer
3 months ago
Xtandi side effect full body rash
Has anyone had a side effect when taking Xtandi. An allergic reaction of full body itchy burning unbearable rash after taking it a week. Took Abiraterone for 4 years with no side effects. PSA started to rise so was switched to Xtandi. They took me off the drug but the rash is horrible. taking prednisone
Has anyone had a side effect when taking Xtandi. An allergic reaction of full body itchy burning unbearable rash after taking it a week. Took Abiraterone for 4 years with no side effects. PSA started to rise so was switched to Xtandi. They took me off the drug but the rash is horrible. taking prednisone
Gern
in
Advanced Prostate Cancer
3 months ago
promising delivery technique for cancer drugs
we will attack you in any possible way from every direction you bastard (ok, I talk to my cancer, don’t call me crazy…I would be crazy if I heard him reply!) https://pubs.acs.org/doi/10.1021/acsbiomaterials.3c01540# from your one reference in the paper: Chondroitin sulfate-hybridized zein nanoparticles
we will attack you in any possible way from every direction you bastard (ok, I talk to my cancer, don’t call me crazy…I would be crazy if I heard him reply!) https://pubs.acs.org/doi/10.1021/acsbiomaterials.3c01540# from your one reference in the paper: Chondroitin sulfate-hybridized zein nanoparticles
Maxone73
in
Advanced Prostate Cancer
3 months ago
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Maybe an alternative to Nattokinase et al, though not yet
Free link to WSJ article https://www.wsj.com/health/pharma/blood-thinners-prevent-clots-bleeding-abd9fdae?st=ofx7h2a2im27x9c&reflink=desktopwebshare_permalink I will study later, but the chemistry is probably beyond me and, anyway, it is not yet available. Factor XI, it turns out, is crucial for
Free link to WSJ article https://www.wsj.com/health/pharma/blood-thinners-prevent-clots-bleeding-abd9fdae?st=ofx7h2a2im27x9c&reflink=desktopwebshare_permalink I will study later, but the chemistry is probably beyond me and, anyway, it is not yet available. Factor XI, it turns out, is crucial for
cigafred
in
Fight Prostate Cancer
3 months ago
SalllyJones
My husband was diagnosed in Jan. 2022 by his Urologist for Stage 3b Highly Aggressive (label they gave it) prostate cancer, Gleason score of 8, into seminal vessicles, but no mets seen on PET Scan. Received Lupron for 18 months and Casodex 50mg was initiated immediately and continued once a day
My husband was diagnosed in Jan. 2022 by his Urologist for Stage 3b Highly Aggressive (label they gave it) prostate cancer, Gleason score of 8, into seminal vessicles, but no mets seen on PET Scan. Received Lupron for 18 months and Casodex 50mg was initiated immediately and continued once a day
SallyJones
in
Advanced Prostate Cancer
3 months ago
Help with Results
I just updated my Bio and just received my PSMA Gallium scan results. Appointment is tomorrow to review but from what I see even with a low PSA of 0.052 a lymph node lit up which is rare. Is this correct and given this my guess SOC is whole pelvic adjuvant radiation and higher dose to lymph nodes or?
I just updated my Bio and just received my PSMA Gallium scan results. Appointment is tomorrow to review but from what I see even with a low PSA of 0.052 a lymph node lit up which is rare. Is this correct and given this my guess SOC is whole pelvic adjuvant radiation and higher dose to lymph nodes or?
Peppertree602
in
Advanced Prostate Cancer
3 months ago
Concern about having more radiation to prostate after 43 external beam treatments 15 years ago
15 years ago my husband had 43 radiation treatments after PSA reached 50 & his 3rd biopsy showed 1 core to have cancer., Gleason was 3-3. He has had Lupron injections since then. He was on 250mg of Zytiga with food and 5 mg Prednisone for 3 years until a year ago because PSA was creeping up & he was
15 years ago my husband had 43 radiation treatments after PSA reached 50 & his 3rd biopsy showed 1 core to have cancer., Gleason was 3-3. He has had Lupron injections since then. He was on 250mg of Zytiga with food and 5 mg Prednisone for 3 years until a year ago because PSA was creeping up & he was
Pickleball38
in
Advanced Prostate Cancer
3 months ago
Meeting with our oncologist for castrate resistance metastatic prostate cancer
We met with my Dad's MO yesterday. (Diagnosed 10/22 with advanced metastatic cancer, became castrate resistant about a year ago.) He shared that the Xtandi is still blocking some cancer growth, but not all of it. His PSA is 2.8 (currently doubling every four weeks.) His PetScan shows some growth (
We met with my Dad's MO yesterday. (Diagnosed 10/22 with advanced metastatic cancer, became castrate resistant about a year ago.) He shared that the Xtandi is still blocking some cancer growth, but not all of it. His PSA is 2.8 (currently doubling every four weeks.) His PetScan shows some growth (
lgutman
in
Advanced Prostate Cancer
3 months ago
Treatment Plan
To update my journey, diagnosed on Oct. 2023 with pc, psa of 24.6. PSMA scan showed one met to sacrum, everything else clear. Did 28 rounds radiation and am currently on Lupron and Xtandi. Urologist yesterday said Lupron for one year then off and watch PSA with new PSMA scan also. Medical oncologist
To update my journey, diagnosed on Oct. 2023 with pc, psa of 24.6. PSMA scan showed one met to sacrum, everything else clear. Did 28 rounds radiation and am currently on Lupron and Xtandi. Urologist yesterday said Lupron for one year then off and watch PSA with new PSMA scan also. Medical oncologist
Jeffdanger
in
Advanced Prostate Cancer
3 months ago
Short-term tactics to keep PSA in check
Good morning fellow warriors. My docetaxel adventure was without side effects but gave an ineffective response. The cabazitaxel/carboplatin combo was effective but brutal in its attack on my immune system. Having had no treatment at all while my body tries to recover, I'm currently being considered by
Good morning fellow warriors. My docetaxel adventure was without side effects but gave an ineffective response. The cabazitaxel/carboplatin combo was effective but brutal in its attack on my immune system. Having had no treatment at all while my body tries to recover, I'm currently being considered by
CrocodileShoes
in
Advanced Prostate Cancer
3 months ago
Chemo or no/not yet?
59 years old. Metastatic/high volume. PSA hit 366 before starting Abiraterone and Degarelix. Start Lupron next week. Negative on DNA test. Will see what PSA looks like next week after a month of ADT. My question chemo, no chemo or wait on chemo? Onco and Rad Onco both seemed to have a very soft attitude
59 years old. Metastatic/high volume. PSA hit 366 before starting Abiraterone and Degarelix. Start Lupron next week. Negative on DNA test. Will see what PSA looks like next week after a month of ADT. My question chemo, no chemo or wait on chemo? Onco and Rad Onco both seemed to have a very soft attitude
4tunate1
in
Advanced Prostate Cancer
3 months ago
PSA increasing
My Dad’s PSA started increasing 2.5 years after diagnosis. It was 0.008 in December, 0.024 at the beginning of March and 0.029 on yesterday. Please advise. Any suggestions are greatly appreciated. He is still taking Lupron, Abiraterone and Prednisone 10 mg that were started back in September of 2021.
My Dad’s PSA started increasing 2.5 years after diagnosis. It was 0.008 in December, 0.024 at the beginning of March and 0.029 on yesterday. Please advise. Any suggestions are greatly appreciated. He is still taking Lupron, Abiraterone and Prednisone 10 mg that were started back in September of 2021.
Simonapo
in
Advanced Prostate Cancer
3 months ago
Was there ever really a chance for a cure?
When I began the Stampede protocol 1 1/2 yrs ago, it was my understanding that two years of Zytiga/Prednisone and three years of Lupon with radiation to the pelvic area at the 7 mo - 1 yr mark gave a chance for a "cure" under my conditions (3+4 gleason, etc). Now, my non-medical view of things is convincing
When I began the Stampede protocol 1 1/2 yrs ago, it was my understanding that two years of Zytiga/Prednisone and three years of Lupon with radiation to the pelvic area at the 7 mo - 1 yr mark gave a chance for a "cure" under my conditions (3+4 gleason, etc). Now, my non-medical view of things is convincing
duxlubber
in
Advanced Prostate Cancer
3 months ago
Xtandi worked great
After radiation to prostate bed and to one pelvic metastasis, I was on xtandi and Lupton for three years and now have been on "vacation " for a year with PSA of 0.02 and testosterone at 4. No meds at all for last11 months!Had a heart attack in May '23 (which I attribute to covid shots) , doctors told
After radiation to prostate bed and to one pelvic metastasis, I was on xtandi and Lupton for three years and now have been on "vacation " for a year with PSA of 0.02 and testosterone at 4. No meds at all for last11 months!Had a heart attack in May '23 (which I attribute to covid shots) , doctors told
JAK2243
in
Advanced Prostate Cancer
3 months ago
Big company buys a clinical research company focused on Actinium 225 (and others) FPI-2265
astra-something buys a Canadian company because they hate Canadians...no, sorry...ok, I will sound like a financial advisor, but here it is: Astra-something has been working on other approaches to develop more targeted cancer treatments, including antibody-drug conjugates and RCs. "The deal has solid
astra-something buys a Canadian company because they hate Canadians...no, sorry...ok, I will sound like a financial advisor, but here it is: Astra-something has been working on other approaches to develop more targeted cancer treatments, including antibody-drug conjugates and RCs. "The deal has solid
Maxone73
in
Advanced Prostate Cancer
3 months ago
Brain Fog or Dimentia?
Hey warriors! So how do you know if you have brain fog or the beginning of dementia? Is it possible to blame ADT and Zytiga? My husband has been on Ellegaard for five years and Zytiga for 2 1/2. Years, he seems to have a lot of memory issues lately, and I fear it’s only getting worse Any thoughts or
Hey warriors! So how do you know if you have brain fog or the beginning of dementia? Is it possible to blame ADT and Zytiga? My husband has been on Ellegaard for five years and Zytiga for 2 1/2. Years, he seems to have a lot of memory issues lately, and I fear it’s only getting worse Any thoughts or
Keeper70
in
Advanced Prostate Cancer
3 months ago
PSA Bounce After Radiation Therapy
I am trying to understand PSA bounce or change in PSA levels after RT and have found two studies useful. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7465291/ https://www.nature.com/articles/s41391-021-00387-4 Some analysts distinguish between PSA bounce and biological recurrence, and see a possibility
I am trying to understand PSA bounce or change in PSA levels after RT and have found two studies useful. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7465291/ https://www.nature.com/articles/s41391-021-00387-4 Some analysts distinguish between PSA bounce and biological recurrence, and see a possibility
kainasar
in
Advanced Prostate Cancer
3 months ago
PSA on the way up again
I am getting a little concerned about a increase in my PSA, and not just the increase, but also the increase in the rate of increase. Short history. Diagnosed March 2021 by MRI and biopsy Gleason 4 + 3, Stage T3B, ISUP 3 ADT (Zoladex) started June 2021 EBRT 60Gy in 20 fractions December 2021 Last
I am getting a little concerned about a increase in my PSA, and not just the increase, but also the increase in the rate of increase. Short history. Diagnosed March 2021 by MRI and biopsy Gleason 4 + 3, Stage T3B, ISUP 3 ADT (Zoladex) started June 2021 EBRT 60Gy in 20 fractions December 2021 Last
ParrotY
in
Prostate Cancer Network
3 months ago
Dutasteride Monotherapy is effective for Newly Diagnosed PCa men not on ADT
This plot shows men that either don't have PCa (Group A) or newly diagnosed men with PCa by biopsy (Group B). Neither group is on ADT. Dutasteride monotherapy (0.5 mg/day) causes an average drop in PSA of about 50% in both Groups, and an average drop of about 20% in prostate volume. In one man, his
This plot shows men that either don't have PCa (Group A) or newly diagnosed men with PCa by biopsy (Group B). Neither group is on ADT. Dutasteride monotherapy (0.5 mg/day) causes an average drop in PSA of about 50% in both Groups, and an average drop of about 20% in prostate volume. In one man, his
janebob99
in
Prostate Cancer Network
3 months ago
HIPEC
Hello everyone, I was diagnosed with stage 3 ovarian cancer in December, I’ve since had 3 cycles of chemo (to which I’ve had a good response) and will be having debulking surgery soon. My surgeon has said I am suitable for HIPEC. The treatment sounds quite intensive and I’m keen to hear from anyone
Hello everyone, I was diagnosed with stage 3 ovarian cancer in December, I’ve since had 3 cycles of chemo (to which I’ve had a good response) and will be having debulking surgery soon. My surgeon has said I am suitable for HIPEC. The treatment sounds quite intensive and I’m keen to hear from anyone
Oaklake
in
My Ovacome
3 months ago
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