we will attack you in any possible way from every direction you bastard (ok, I talk to my cancer, don’t call me crazy…I would be crazy if I heard him reply!)
pubs.acs.org/doi/10.1021/ac...
from your one reference in the paper:
Chondroitin sulfate-hybridized zein nanoparticles (zein/CS NPs) were developed for targeted delivery of docetaxel, which exhibited mean diams. of 157.8 ± 3.6 nm and docetaxel encapsulation efficiency of 64.2 ± 1.9%. Docetaxel was released from the NPs in a sustained manner (∼72 h), following first-order kinetics. The zein/CS NPs showed improved colloidal stability, maintaining the initial size in serum for 12 h. The pre-treatment of CS reduced the uptake efficiency of the NPs by 23% in PC-3 cells, suggesting the involvement of CD44-mediated uptake mechanism. The NPs showed 2.79-fold lower IC50 values than free docetaxel. Enhanced tumor accumulation of the NPs was confirmed in PC-3 xenograft mice by near-IR fluorescence imaging (35.3-fold, vs. free Cy5.5). The NPs exhibited improved pharmacokinetic properties (9.5-fold longer terminal half-life, vs. free docetaxel) and anti-tumor efficacy comparable to Taxotere with negligible systemic toxicity, suggesting zein/CS NPs could be a promising nanoplatform for targeted cancer therapy.
So, good pharmacokinetic and low toxicity…