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Proximity proteomic analysis of the NRF family reveals the Parkinson’s disease protein ZNF746/PARIS as a co-complexed repressor of NRF2
Proximity proteomic analysis of the NRF family reveals the Parkinson’s disease protein ZNF746/PARIS as a co-complexed repressor of NRF2
https://www.science.org/doi/10.1126/scisignal.adi9018 "Editor’s summary: The cell death that occurs in neurodegenerative diseases is due partly to decreased
Proximity proteomic analysis of the NRF family reveals the Parkinson’s disease protein ZNF746/PARIS as a co-complexed repressor of NRF2
https://www.science.org/doi/10.1126/scisignal.adi9018 "Editor’s summary: The cell death that occurs in neurodegenerative diseases is due partly to decreased
Bolt_Upright
in
Cure Parkinson's
7 months ago
Role of Luteolin in overcoming Parkinson's disease 2021
Role of Luteolin in overcoming Parkinson's disease 2021
https://sci-hub.ru/10.1002/biof.1706 "The incidence of life threating neurodegenerative diseases such as PD is increasing day by day. Sporadic as well as genetic causes are well documented. Due to the decline in the dopaminergic neurons,
Role of Luteolin in overcoming Parkinson's disease 2021
https://sci-hub.ru/10.1002/biof.1706 "The incidence of life threating neurodegenerative diseases such as PD is increasing day by day. Sporadic as well as genetic causes are well documented. Due to the decline in the dopaminergic neurons,
Bolt_Upright
in
Cure Parkinson's
7 months ago
Advice please?
Hi all. I just wanted to see if anybody has experienced the same as me. I am a 28 year old male. I used to drink very heavily for around 6-7 years. I drank vodka with lemonade and could get through a couple of litres a week following my dad's death (not an excuse but it is the reason I drank so much
Hi all. I just wanted to see if anybody has experienced the same as me. I am a 28 year old male. I used to drink very heavily for around 6-7 years. I drank vodka with lemonade and could get through a couple of litres a week following my dad's death (not an excuse but it is the reason I drank so much
Connorsw95
in
British Liver Trust
7 months ago
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Doing the rounds of doctors again.
Early last month I went to Japan and met my daughter who's living over there. As we set off I was getting quite short of breath and my daughter (who is a doctor) started quizzing me as to why I was short of breath. I did try to brush it off-saying I was old and unfit but she kept persisting and told
Early last month I went to Japan and met my daughter who's living over there. As we set off I was getting quite short of breath and my daughter (who is a doctor) started quizzing me as to why I was short of breath. I did try to brush it off-saying I was old and unfit but she kept persisting and told
Ozchick
in
Hughes Syndrome APS Forum
1 year ago
Lupus participants needed for a study with The University of Edinburgh!
Do you have Systemic Lupus and currently experience disordered eating? If you're 18+ years old, we want to hear about your experience. For more information, please contact: l.bruha@sms.ed.ac.uk by email or via Instagram @thelupusexperience Thank you for your time.
Do you have Systemic Lupus and currently experience disordered eating? If you're 18+ years old, we want to hear about your experience. For more information, please contact: l.bruha@sms.ed.ac.uk by email or via Instagram @thelupusexperience Thank you for your time.
michaellasmith
Administrator
in
LUPUS UK
4 months ago
Low BP
I've used Amlodipine for long time to help Raynauds, recently BP has become quite low so have stopped Amlodipine. Has anyone used Naftidrofuryl as it has been suggested as doesn't lower BP.
I've used Amlodipine for long time to help Raynauds, recently BP has become quite low so have stopped Amlodipine. Has anyone used Naftidrofuryl as it has been suggested as doesn't lower BP.
Fishie1
in
Scleroderma & Raynaud's UK (SRUK)
2 months ago
Deuterium Depleted Water
OK guys, I've been looking at this for a while and thought I'd condense it down and share it with you guys.I'm really not interested in arguments with people. If you don't agree, get yourself a cup of coffee, chill out and move on. Water his made of hydrogen and oxygen. Deuterium is a hydrogen isotope
OK guys, I've been looking at this for a while and thought I'd condense it down and share it with you guys.I'm really not interested in arguments with people. If you don't agree, get yourself a cup of coffee, chill out and move on. Water his made of hydrogen and oxygen. Deuterium is a hydrogen isotope
MrG68
in
Advanced Prostate Cancer
7 months ago
PNT article on recent success in generating locus coeruleus (LC) norepinephrine (NE) neurons, to study their role in diseases such as PD.
"Nerve cells originating in the locus coeruleus extend throughout the brain and spinal cord via an extensive branching system, where they release norepinephrine to regulate heartbeat, blood pressure, arousal, memory, and attention." "In Parkinson’s, the locus coeruleus is one of the first brain regions
"Nerve cells originating in the locus coeruleus extend throughout the brain and spinal cord via an extensive branching system, where they release norepinephrine to regulate heartbeat, blood pressure, arousal, memory, and attention." "In Parkinson’s, the locus coeruleus is one of the first brain regions
jeffreyn
in
Cure Parkinson's
7 months ago
Hi everyone
Hi, it’s been a while but I’m still getting on with it , just out of hospital yet again with pericarditis again! I’m now on anti inflammatory medication and another 2 weeks of antibiotics for a kleibsom infection they haven’t cleared since December, I can’t remember the spelling but it’s a nasty bug.
Hi, it’s been a while but I’m still getting on with it , just out of hospital yet again with pericarditis again! I’m now on anti inflammatory medication and another 2 weeks of antibiotics for a kleibsom infection they haven’t cleared since December, I can’t remember the spelling but it’s a nasty bug.
Numptybrain
in
Lung Conditions Community Forum
4 months ago
Morning all!
woke this morning achey and bit shake.. not great night sleep lolmy question is please on Saturday I reduce from 9 pred down to 6...still no rheumatoid apps. how will I know if 6 is enough...Will the headaches return and if so..how long b4 they come back ? feel like opthalmology did good job but have
woke this morning achey and bit shake.. not great night sleep lolmy question is please on Saturday I reduce from 9 pred down to 6...still no rheumatoid apps. how will I know if 6 is enough...Will the headaches return and if so..how long b4 they come back ? feel like opthalmology did good job but have
Alliekat65
in
PMRGCAuk
4 months ago
psoriatic arthritis
Has anyone with psoriatic arthritis had pain in their calves and swelling in both ankles above the heels???
Has anyone with psoriatic arthritis had pain in their calves and swelling in both ankles above the heels???
Beata0102
in
NRAS
4 months ago
Update-Covid antiviral
This evening I finally got the call from a consultant from , Stoke Mandeville hospital.Booked in for liver and kidney blood test and infusion .... what a relief . Just want to feel better. Thank you all for your advice and care. 😊
This evening I finally got the call from a consultant from , Stoke Mandeville hospital.Booked in for liver and kidney blood test and infusion .... what a relief . Just want to feel better. Thank you all for your advice and care. 😊
Stavrou1
in
CLL Support
7 months ago
Declining psa #8
Gm folks, hope all is well during this Christmas season… I’ve just received my 8th psa test after getting off ADT, 9 months of using alternative meds ivermectin, cbd oil turmeric zinc ashwaganda n dim a natural estrogen blocker solely. Psa came in at .95 down from 1.29, 6 weeks ago and down from 1.95
Gm folks, hope all is well during this Christmas season… I’ve just received my 8th psa test after getting off ADT, 9 months of using alternative meds ivermectin, cbd oil turmeric zinc ashwaganda n dim a natural estrogen blocker solely. Psa came in at .95 down from 1.29, 6 weeks ago and down from 1.95
Nfler
in
Advanced Prostate Cancer
7 months ago
knocked sideways
Ive been reading all your posts but not actually written anything for a while because in my stupid head I thought we were plodding along even if it was at a plateau level. Kev was diagnosed with non alcoholic liver cirrhosis back in July. He also had sepsis twice and ended up in intensive care where
Ive been reading all your posts but not actually written anything for a while because in my stupid head I thought we were plodding along even if it was at a plateau level. Kev was diagnosed with non alcoholic liver cirrhosis back in July. He also had sepsis twice and ended up in intensive care where
Snips71
in
Liver4Life
7 months ago
Is this a lupus rash?
this is a rash on my leg it is appearing everywhere!
this is a rash on my leg it is appearing everywhere!
Jolevans
in
LUPUS UK
4 months ago
combining standard PCA care with alternative care
In a three month period my PSA went from 58 to 70. Obviously my testosterone was producing more new cancer cells than my alternative treatment. I started the combination treatment on Dec 1 by taking 2 ORGOVYX. Dec 15 my PSA is 27.5 and I will take one more ORGOVYX today hoping to reduce PSA to 10
In a three month period my PSA went from 58 to 70. Obviously my testosterone was producing more new cancer cells than my alternative treatment. I started the combination treatment on Dec 1 by taking 2 ORGOVYX. Dec 15 my PSA is 27.5 and I will take one more ORGOVYX today hoping to reduce PSA to 10
agnut
in
Fight Prostate Cancer
7 months ago
HRT anyone?
Hi all, I was diagnosed with Lupus last June. Luckily my symptoms are mild - and my rhumatologist agreed that i didn't need to start hydroxyholorquine if I didn't want to. I'm definitely peri-menopausal and a lot of "symptoms" of lupus overlap with perimenopause and my rhumatologist agreed it's
Hi all, I was diagnosed with Lupus last June. Luckily my symptoms are mild - and my rhumatologist agreed that i didn't need to start hydroxyholorquine if I didn't want to. I'm definitely peri-menopausal and a lot of "symptoms" of lupus overlap with perimenopause and my rhumatologist agreed it's
NewLupusdiag
in
LUPUS UK
4 months ago
⏰Do you have 15 minutes to spare?⏰
🌟 PARTICIPATE IN A RESEARCH STUDY EXPLORING THE CONNECTIONS BETWEEN PVCS 🫀, MENTAL WELL-BEING 🧠, HEALTH BEHAVIOURS🚶♂️, AND QUALITY OF LIFE! 🌟 🔍 What's Involved? 🔍 Complete two online surveys on Qualtrics. The first is a 15-minute exploration of your PVC journey; the second is a quick 5-minute
🌟 PARTICIPATE IN A RESEARCH STUDY EXPLORING THE CONNECTIONS BETWEEN PVCS 🫀, MENTAL WELL-BEING 🧠, HEALTH BEHAVIOURS🚶♂️, AND QUALITY OF LIFE! 🌟 🔍 What's Involved? 🔍 Complete two online surveys on Qualtrics. The first is a 15-minute exploration of your PVC journey; the second is a quick 5-minute
TracyAdmin
ArrhythmiaAlliance
in
Heart Rhythm Disorders Support
2 months ago
14 months post Successful Ablation & increasing Arrythmias.
Hi I am getting Arrythmias with increasing regularity after ablation Feb 23.Last talk with Arrythmia Nurse was Atrial ectopics with pause.My readings now seem to have chucked in a couple of premature beats. It feels like I am having AFib symptoms.Light headed,dizzy, exhausted but not all the time. Where
Hi I am getting Arrythmias with increasing regularity after ablation Feb 23.Last talk with Arrythmia Nurse was Atrial ectopics with pause.My readings now seem to have chucked in a couple of premature beats. It feels like I am having AFib symptoms.Light headed,dizzy, exhausted but not all the time. Where
kkatz
in
Atrial Fibrillation Support
2 months ago
PSA on the rise
Good morning everyone, my PSA has been undectable, {<.01} since July 2022. Not real long, but it has been a good time. Felt good, no pain, can look on my profile for more details. I am on Xtandi and Lupron--(3 months). (I had taxetere in 2021) I get my PSA checked every three months right before
Good morning everyone, my PSA has been undectable, {<.01} since July 2022. Not real long, but it has been a good time. Felt good, no pain, can look on my profile for more details. I am on Xtandi and Lupron--(3 months). (I had taxetere in 2021) I get my PSA checked every three months right before
JD-guy
in
Advanced Prostate Cancer
7 months ago
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