Proximity proteomic analysis of the NRF family reveals the Parkinson’s disease protein ZNF746/PARIS as a co-complexed repressor of NRF2

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Proximity proteomic analysis of the NRF family reveals the Parkinson’s disease protein ZNF746/PARIS as a co-complexed repressor of NRF2 science.org/doi/10.1126/sci...

"Editor’s summary: The cell death that occurs in neurodegenerative diseases is due partly to decreased function of the transcription factor NRF2, which mounts cellular responses to oxidative stress. LaPak et al. sought to identify binding partners for NRF2 and related family members with proximity proteomic analysis. They found that the transcription finger ZNF746 (also known as PARIS), which is increased in abundance in Parkinson’s disease, bound to and repressed the activity of NRF2. A neuronal cell line commonly used in Parkinson’s disease studies showed greater apoptosis and oxidative stress upon ZNF746 overexpression. These data reveal a potential mechanism that may contribute to the suppression of NRF2 activity in Parkinson’s disease. —Wei Wong"

I have a High School degree and no medical training, but I think my daily dose of broccoli sprouts are boosting NRF2, and if PD represses NRF2, then boosting it might be a good idea. Or not. I am not giving advice.

Exploring the anti-inflammatory activity of sulforaphane 2023 onlinelibrary.wiley.com/doi...

(This study has a Summary of studies on sulforaphane/glucoraphanin given to human volunteers in vivo) "The phytochemical sulforaphane, well established as an activator of NRF2 antioxidant signaling, has demonstrated broad anti-inflammatory effects."

I will continue my daily breakfast of a 1.5 cups of broccoli sprouts. rbd-pd-protocols.blogspot.c...