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Enzalutamide or Darolutamide
Hi, I have advanced metastatic hormone sensitive prostate cancer and as well as my usual three monthly ADT (Lucrin-Depot) injection, I have been offered either Enzalutamide (Xtandi) or Darolutamide (Nubeqa). My PSA is currently below 0.1 due to the Lucrin-Depot. I am a bit nervous at taking additional
Hi, I have advanced metastatic hormone sensitive prostate cancer and as well as my usual three monthly ADT (Lucrin-Depot) injection, I have been offered either Enzalutamide (Xtandi) or Darolutamide (Nubeqa). My PSA is currently below 0.1 due to the Lucrin-Depot. I am a bit nervous at taking additional
x-rays1
in
Advanced Prostate Cancer
1 year ago
If all treatment has failed do you continue with ADT?
Now that all treatment has failed to stop the beast do you continue ADT ? Husband has failed out of 6 pluvicto and now 6 Jevtana. No further treatment is planned. Any reason to continue?
Now that all treatment has failed to stop the beast do you continue ADT ? Husband has failed out of 6 pluvicto and now 6 Jevtana. No further treatment is planned. Any reason to continue?
Cynthgob
in
Advanced Prostate Cancer
1 year ago
Followup on friend I mentioned.
He just got biopsy back. Lotta 4+3. His wife however, is telling me the Doc is saying it's Stage 1., which is absurd unless I'm woefully ill-informed. There is a good chance of miscommunication here. They go back to Urologist Thursday, so perhaps I'm posting this prematurely. (I have their permission
He just got biopsy back. Lotta 4+3. His wife however, is telling me the Doc is saying it's Stage 1., which is absurd unless I'm woefully ill-informed. There is a good chance of miscommunication here. They go back to Urologist Thursday, so perhaps I'm posting this prematurely. (I have their permission
WhatHump
in
Prostate Cancer Network
1 year ago
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Can you really end all ADT?
Hello all warriors! My husband is on 23 of 44 IG/IMRT treatments. Radiology Oncologist has suggested he stop all Elligard & Zytiga ehen he finishes his radiation treatments His 2nd opinion radiologist determined that bone Mets at dx were likely” over called “ What’s your opinion? He hates how he
Hello all warriors! My husband is on 23 of 44 IG/IMRT treatments. Radiology Oncologist has suggested he stop all Elligard & Zytiga ehen he finishes his radiation treatments His 2nd opinion radiologist determined that bone Mets at dx were likely” over called “ What’s your opinion? He hates how he
Keeper70
in
Advanced Prostate Cancer
1 year ago
PSA after 4-5 months on Lupron (Scholz)?
Just watched a Scholz (PCRI) video posted last week about PSA. He said multiple times that PSA should reach a nadir of <0.1 after 4-5 months on 1st generation ADT and that if it didn't "[i]something's wrong, that is an unusual type of prostate cancer that has some hormone resistance and studies over
Just watched a Scholz (PCRI) video posted last week about PSA. He said multiple times that PSA should reach a nadir of <0.1 after 4-5 months on 1st generation ADT and that if it didn't "[i]something's wrong, that is an unusual type of prostate cancer that has some hormone resistance and studies over
Gl448
in
Advanced Prostate Cancer
1 year ago
Triple Therapy
I started with Lupron+Abiraterone + Docetaxel. As I mentioned before elevated liver enzymes caused MO to place me on an Abiraterone vacation after cycle 1 of Docetaxel. Docetaxel was reduced to 3/4 dosage. Yesterday, I received my 3rd cycle of 3/4 dosage of Docetaxel, my 3 month injection of Lupron
I started with Lupron+Abiraterone + Docetaxel. As I mentioned before elevated liver enzymes caused MO to place me on an Abiraterone vacation after cycle 1 of Docetaxel. Docetaxel was reduced to 3/4 dosage. Yesterday, I received my 3rd cycle of 3/4 dosage of Docetaxel, my 3 month injection of Lupron
TMcgee
in
Advanced Prostate Cancer
1 year ago
Almost forgot I have PC
I have been off the grid for a while. Back in late November, I started having bladder problems including bleeding, urgency, frequency and incontinence. In December I was diagnosed with stage 3/b bladder cancer. In late January I had open Cystectomy and was in the hospital for 10 days. My MO put my PC
I have been off the grid for a while. Back in late November, I started having bladder problems including bleeding, urgency, frequency and incontinence. In December I was diagnosed with stage 3/b bladder cancer. In late January I had open Cystectomy and was in the hospital for 10 days. My MO put my PC
old64horn
in
Advanced Prostate Cancer
1 year ago
Enzalutamide/Xtandi monotherapy as ADT with fewer side effects than Lupron
Enzalutamide monotherapy can improve the quality of live for advanced prostate cancer patients. Thank you, Prof. Tombal, for promoting this arm in the Embark trial! Enzalutamide does not lower testosterone and estrogen, it even increases the level of these. This avoids the following side effects of
Enzalutamide monotherapy can improve the quality of live for advanced prostate cancer patients. Thank you, Prof. Tombal, for promoting this arm in the Embark trial! Enzalutamide does not lower testosterone and estrogen, it even increases the level of these. This avoids the following side effects of
GP24
in
Advanced Prostate Cancer
1 year ago
Xtandi (enzalutamide) alone is superior to ADT alone at preventing metastases in "high-risk" recurrent men
"High-Risk"recurrence was defined as men who have had primary therapy (prostatectomy or radiation) but have had rising PSA but no detectable (on bone scan/CT) metastases yet and T≥150 ng/dl, and: • PSA doubling time ≤ 9 months, or • PSA≥ 1 ng/ml post-prostatectomy, or • PSA≥ nadir+2 ng/ml post-primary
"High-Risk"recurrence was defined as men who have had primary therapy (prostatectomy or radiation) but have had rising PSA but no detectable (on bone scan/CT) metastases yet and T≥150 ng/dl, and: • PSA doubling time ≤ 9 months, or • PSA≥ 1 ng/ml post-prostatectomy, or • PSA≥ nadir+2 ng/ml post-primary
Tall_Allen
in
Advanced Prostate Cancer
1 year ago
Low T
My husband has been on "vacation" from ADT, zytiga and prednisone for a year. His PSA is tested every 3 months. Today's number is still <0.1 ng/ml. However, his T was slowly building...17, 24, 42 and now dropping to 34. Should I be worried?
My husband has been on "vacation" from ADT, zytiga and prednisone for a year. His PSA is tested every 3 months. Today's number is still <0.1 ng/ml. However, his T was slowly building...17, 24, 42 and now dropping to 34. Should I be worried?
mustang-66
in
Advanced Prostate Cancer
1 year ago
Rethinking Radiation to spine
Has anybody here had radiation to spine mets as treatment only? Not for pain relief necessarily. I am waiting for approval from insurance to radiate 4 smalls spots only seen on Pylarify PET. I had the risks explained to me and my concern is that maybe I should let the ADT and 2nd gen do its work and
Has anybody here had radiation to spine mets as treatment only? Not for pain relief necessarily. I am waiting for approval from insurance to radiate 4 smalls spots only seen on Pylarify PET. I had the risks explained to me and my concern is that maybe I should let the ADT and 2nd gen do its work and
treedown
in
Advanced Prostate Cancer
1 year ago
Additional Drug Choice
I started my ADT treatment with Eligard and Xtandi but had to change due to the cardiovascular side effects. I have been on Orgovyx alone for 10 months. My PSA is undetectable and my testosterone is 13. The drug is doing what it should. Side effects are hot flashes, fatigue, weight gain, and muscle loss
I started my ADT treatment with Eligard and Xtandi but had to change due to the cardiovascular side effects. I have been on Orgovyx alone for 10 months. My PSA is undetectable and my testosterone is 13. The drug is doing what it should. Side effects are hot flashes, fatigue, weight gain, and muscle loss
jcarey79
in
Advanced Prostate Cancer
1 year ago
Clear PSMA scan.?
I started your journey in2018 with a G 3+4 and PSA of 28 ..I went on ADT and had Cyberknife SBRT treatment on my prostate and a suspect rib spot after a PSMA scan , All was good until my psa started to rise when I came off ADT ..My PSA went from 0.06 to 1.2 over a year . I’ve had another PSMA scan in
I started your journey in2018 with a G 3+4 and PSA of 28 ..I went on ADT and had Cyberknife SBRT treatment on my prostate and a suspect rib spot after a PSMA scan , All was good until my psa started to rise when I came off ADT ..My PSA went from 0.06 to 1.2 over a year . I’ve had another PSMA scan in
Walliam
in
Advanced Prostate Cancer
1 year ago
Next Step?
I have been treated for more than 10 years (except for 3 vacations during the first 5 years) and for the most part have been on Lupron and Zytiga. Starting 2 years ago my PSA starting rising from below .05 (MSKCC doesn't measure anything lower than that) up to about .32 over the course of a year. At
I have been treated for more than 10 years (except for 3 vacations during the first 5 years) and for the most part have been on Lupron and Zytiga. Starting 2 years ago my PSA starting rising from below .05 (MSKCC doesn't measure anything lower than that) up to about .32 over the course of a year. At
jfoesq
in
Advanced Prostate Cancer
1 year ago
Testosterone return?
I had my last Lupron injection 6/14/22 after 18 months of ADT and Radiation. PSA at the end of December was <.03 and testosterone was<3. My question is can I expect to return any time soon? My age is 75 and I am physically fit I am doing 5 or 6 miles walking everyday. Do they ever boost ones testosterone
I had my last Lupron injection 6/14/22 after 18 months of ADT and Radiation. PSA at the end of December was <.03 and testosterone was<3. My question is can I expect to return any time soon? My age is 75 and I am physically fit I am doing 5 or 6 miles walking everyday. Do they ever boost ones testosterone
pkat
in
Advanced Prostate Cancer
1 year ago
Who got their T level done before ADT?
I was a month into ADT before I realized that I had no baseline Testosterone number!I know the treatment is all about reducing T, but now that I'm considering vacation possibilities I think it would be helpful to know what my unadjusted level was. I think it would be helpful, but honestly I'm not sure
I was a month into ADT before I realized that I had no baseline Testosterone number!I know the treatment is all about reducing T, but now that I'm considering vacation possibilities I think it would be helpful to know what my unadjusted level was. I think it would be helpful, but honestly I'm not sure
Lewellen
in
Advanced Prostate Cancer
1 year ago
Time for a vacation, but worried about IADT
Decision time is approaching but should I take an ADT vacation? Any new data or articles to support decisions on intermittent ADT? I'm looking forward to an improved QoL but just worried about giving the beast room to come back. I've been undetectable (<0.01) since treatment started 11 months
Decision time is approaching but should I take an ADT vacation? Any new data or articles to support decisions on intermittent ADT? I'm looking forward to an improved QoL but just worried about giving the beast room to come back. I've been undetectable (<0.01) since treatment started 11 months
PGDuan
in
Advanced Prostate Cancer
1 year ago
Questions about hormone therapy...
Greetings, I was diagnosed with prostate cancer, Gleason 8, no indication of metastasis in January. I just had a radical prostatectomy, including the removal of nerves. Post surgery pathology downgraded the two legions to a Gleason 5 and a Gleason 7, with no indication of any cancer touching the anterior
Greetings, I was diagnosed with prostate cancer, Gleason 8, no indication of metastasis in January. I just had a radical prostatectomy, including the removal of nerves. Post surgery pathology downgraded the two legions to a Gleason 5 and a Gleason 7, with no indication of any cancer touching the anterior
JetBoy
in
Prostate Cancer And Gay Men
1 year ago
bone pain after ADT
my husband had three years of adt plus 45 rounds of radiation. One lymph node Was involved so he was considered stage iii at dx. His psa went from 49 to >.04 In the first three months and never went up. He now has NED and will be checked every three months. Problem is, after coming off three years
my husband had three years of adt plus 45 rounds of radiation. One lymph node Was involved so he was considered stage iii at dx. His psa went from 49 to >.04 In the first three months and never went up. He now has NED and will be checked every three months. Problem is, after coming off three years
Kinggip2
in
Advanced Prostate Cancer
1 year ago
treatment decision
Anyone on here been treated with MSK Precise® Radiation Therapy? I was diagnosed with G 3+4 one year ago & after researching & second opinions and more testing, I qualify for this treatment at MSK. 5 treatments & no ADT. https://www.mskcc.org/cancer-care/diagnosis-treatment/cancer-treatments/radiation-therapy
Anyone on here been treated with MSK Precise® Radiation Therapy? I was diagnosed with G 3+4 one year ago & after researching & second opinions and more testing, I qualify for this treatment at MSK. 5 treatments & no ADT. https://www.mskcc.org/cancer-care/diagnosis-treatment/cancer-treatments/radiation-therapy
930911
in
Prostate Cancer Network
1 year ago
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