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Olaparib for Metastatic Castration-Resistant Prostate Cancer With BRCA1 and/or BRCA2 Alterations
TAKE-HOME MESSAGE The phase III PROfound trial showed that patients with metastatic castration-resistant prostate cancer who have BRCA and/or ATM mutations had improved survival outcomes with olaparib monotherapy compared with
abiraterone
or enzalutamide therapy.
TAKE-HOME MESSAGE The phase III PROfound trial showed that patients with metastatic castration-resistant prostate cancer who have BRCA and/or ATM mutations had improved survival outcomes with olaparib monotherapy compared with
abiraterone
or enzalutamide therapy.
Balsam01
in
Advanced Prostate Cancer
7 months ago
A quick introduction
I was immediately given Lupron and
Abiraterone
/prednasone. This was replaced by Nubeqa after only a month. In early June I began what was to be six rounds of docetaxal. Apparently I responded well to the treatment as my MO put my chemotherapy on “pause” after four rounds.
I was immediately given Lupron and
Abiraterone
/prednasone. This was replaced by Nubeqa after only a month. In early June I began what was to be six rounds of docetaxal. Apparently I responded well to the treatment as my MO put my chemotherapy on “pause” after four rounds.
Pinkyboy
in
Advanced Prostate Cancer
7 months ago
Visceral fat
where is it coming from, Lupron or
abiraterone
?
where is it coming from, Lupron or
abiraterone
?
TuffNuttoCrack
in
Advanced Prostate Cancer
10 months ago
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Mets to lungs and lymph nodes need some advice
Hi there, i was diagnosed with oligometastatic pca 6 years ago,51 yo psa was 25, tried to go on a curative path and went for prostatectomy followed with radiotherapy +sbrt to ilium bone suspicion for bone met and pelvic lymph nodes +adt and
abiraterone
for 24 months.I have refused to chemo along
Hi there, i was diagnosed with oligometastatic pca 6 years ago,51 yo psa was 25, tried to go on a curative path and went for prostatectomy followed with radiotherapy +sbrt to ilium bone suspicion for bone met and pelvic lymph nodes +adt and
abiraterone
for 24 months.I have refused to chemo along
Niso
in
Advanced Prostate Cancer
6 months ago
Failing ADT
Following a PSMA scan, my MO saw only my largest tumor growing and suggested we radiate it and continue with Lupron and
Abiraterone
. That seems to have worked for a short as my PSA became immeasurable once again.
Following a PSMA scan, my MO saw only my largest tumor growing and suggested we radiate it and continue with Lupron and
Abiraterone
. That seems to have worked for a short as my PSA became immeasurable once again.
jfoesq
in
Advanced Prostate Cancer
6 months ago
UPDATE on my dad. A story of hope.❤️ #advancedPC
He’s been on daily
Abiraterone
1000 and prednisone 5 mgs and ELIGARD shot every 6 months. Also supplements high doses Curcumin, c60, garlic, ionic calcium, Vit D, and more and THC/CBD. He eats a very clean 95% whole foods diet. Mediterranean diet. My dad has tremendous faith in God.
He’s been on daily
Abiraterone
1000 and prednisone 5 mgs and ELIGARD shot every 6 months. Also supplements high doses Curcumin, c60, garlic, ionic calcium, Vit D, and more and THC/CBD. He eats a very clean 95% whole foods diet. Mediterranean diet. My dad has tremendous faith in God.
YC22
in
Advanced Prostate Cancer
4 months ago
I wonder if anyone knows why or has experienced a rise on PSA level (from 70 to 274), 6 months after radiation therapy (VMAT x 26 sessions)?
Instead, take
Abiraterone
Acetate with Prednisone.
Instead, take
Abiraterone
Acetate with Prednisone.
Iloveyoudad
in
Advanced Prostate Cancer
9 months ago
Abiraterone, standard or low dose.
I was wondering if many of the members take low dose
abiraterone
(250 mg and 300 calorie breakfast) and how many take the standard dose. And whether it was a patient doctor decision based on cost, toxicity, or some other reason.
I was wondering if many of the members take low dose
abiraterone
(250 mg and 300 calorie breakfast) and how many take the standard dose. And whether it was a patient doctor decision based on cost, toxicity, or some other reason.
Professorgary
in
Advanced Prostate Cancer
10 months ago
Getting Ready to Start Abiraterone
I am getting ready to start
abiraterone
(1000) mg with 5 mg prednisone once daily. I have been thoroughly instructed on taking the
abiraterone
with no food two hours before and one hour after as well as taking prednisone with food but was wondering when you guys take yours.
I am getting ready to start
abiraterone
(1000) mg with 5 mg prednisone once daily. I have been thoroughly instructed on taking the
abiraterone
with no food two hours before and one hour after as well as taking prednisone with food but was wondering when you guys take yours.
Professorgary
in
Advanced Prostate Cancer
10 months ago
Enzalutamide any advice/tips for dealing with side effects
Had 6 cycles of Chemo and then
Abiraterone
for 18+ months (PSA dropped to 0.2 then more recently rose to 58 in June '23 ).
Abiraterone
eventually stopped working and I was able to join Radium 223 trial.
Had 6 cycles of Chemo and then
Abiraterone
for 18+ months (PSA dropped to 0.2 then more recently rose to 58 in June '23 ).
Abiraterone
eventually stopped working and I was able to join Radium 223 trial.
Ronnie7C
in
Advanced Prostate Cancer
10 months ago
PARP inhibitor Olaparib, phase 3 study findings (PROpel)
https://www.urotoday.com/recent-abstracts/urologic-oncology/prostate-cancer/152812-olaparib-plus-
abiraterone
-versus-placebo-plus-
abiraterone
-in-metastatic-castration-resistant-prostate-cancer-propel-final-prespecified-overall-survival-results-of-a-randomised-double-blind-phase-3-trial-beyond-the-abstract.html
https://www.urotoday.com/recent-abstracts/urologic-oncology/prostate-cancer/152812-olaparib-plus-
abiraterone
-versus-placebo-plus-
abiraterone
-in-metastatic-castration-resistant-prostate-cancer-propel-final-prespecified-overall-survival-results-of-a-randomised-double-blind-phase-3-trial-beyond-the-abstract.html
Maxone73
in
Advanced Prostate Cancer
20 days ago
My 80 year-old dad with MPCa, broke his leg and now seems to be giving up. Advice on best anti-anxiety meds desperately needed.
He had been on
abiraterone
and pred but his PSA had been rising rapidly. Hence the plan to start Xofigo. Till early June he was healing, going out with a zimmer and doing ok. Sadly over last two weeks he has tanked precipitously and is now almost constantly bed bound.
He had been on
abiraterone
and pred but his PSA had been rising rapidly. Hence the plan to start Xofigo. Till early June he was healing, going out with a zimmer and doing ok. Sadly over last two weeks he has tanked precipitously and is now almost constantly bed bound.
Lemonpower
in
Advanced Prostate Cancer
14 days ago
Antiandrogen Withdrawal Syndrome After Stopping Enzalutamide in Metastatic Castration-Resistant Prostate Cancer: Two Case Reports & Review
This was initially described for older agents, such as flutamide, bicalutamide, and nilutamide; moreover, before the approval of enzalutamide and
abiraterone
, this phenomenon could be used to postpone the beginning of chemotherapy in mCRPC [7]. AAWS after enzalutamide is not well established.
This was initially described for older agents, such as flutamide, bicalutamide, and nilutamide; moreover, before the approval of enzalutamide and
abiraterone
, this phenomenon could be used to postpone the beginning of chemotherapy in mCRPC [7]. AAWS after enzalutamide is not well established.
God_Loves_Me
in
Advanced Prostate Cancer
18 days ago
Abiraterone Zytiga Major Price Jump! $$$$
just went to renew my monthly prescription of Abby Rader Rowan, and was told it had jumped from 160 per month to $1600 per month. Went to good RX and all the prices have quintupled or sextupled. Anyone have a clue why? Anyone know a better source for those of us on Medicare and supplemental health?
just went to renew my monthly prescription of Abby Rader Rowan, and was told it had jumped from 160 per month to $1600 per month. Went to good RX and all the prices have quintupled or sextupled. Anyone have a clue why? Anyone know a better source for those of us on Medicare and supplemental health?
Spyder54
in
Advanced Prostate Cancer
9 months ago
low dose abiraterone and possible pain
Does anybody here find low dose protocol of
abiraterone
effective? Also, how do you treat bone pain? Or how do you determine if pain is coming from the bone or some other factors like chronic pelvic-prostate syndrome?
Does anybody here find low dose protocol of
abiraterone
effective? Also, how do you treat bone pain? Or how do you determine if pain is coming from the bone or some other factors like chronic pelvic-prostate syndrome?
dnmrk
in
Advanced Prostate Cancer
10 months ago
Radiation Question
PSA test sent me into this journey about 8 mos ago, Gleason 6-7-8s, good PSMA PET/CT did not show uptake outside of the prostate, 6 mos now on
Abiraterone
and Zytiga brought PSA to .31, now suggesting radiation, went to see RO and they want to start right away, 8 weeks x-ray type to include abdomen in
PSA test sent me into this journey about 8 mos ago, Gleason 6-7-8s, good PSMA PET/CT did not show uptake outside of the prostate, 6 mos now on
Abiraterone
and Zytiga brought PSA to .31, now suggesting radiation, went to see RO and they want to start right away, 8 weeks x-ray type to include abdomen in
jgsdone
in
Advanced Prostate Cancer
9 months ago
Hospitalizations Among Veterans Treated for Metastatic Prostate Cancer With Abiraterone or Enzalutamide
This study compares hospitalizations among patients treated initially with
abiraterone
versus enzalutamide. Total rate of hospitalization increased 22% for
abiraterone
compared to a 3% increase for enzalutamide in the 12 months after ARPI initiation (P < .0001).
This study compares hospitalizations among patients treated initially with
abiraterone
versus enzalutamide. Total rate of hospitalization increased 22% for
abiraterone
compared to a 3% increase for enzalutamide in the 12 months after ARPI initiation (P < .0001).
kainasar
in
Advanced Prostate Cancer
11 months ago
Switching from Abi to Enza?
However,
Abiraterone
has resulted in some side effects, the major one being increase in blood sugar levels. My father has become pre-diabetic now and the doctor has advised to switch to Enzalutamide as it has fewer side effects.
However,
Abiraterone
has resulted in some side effects, the major one being increase in blood sugar levels. My father has become pre-diabetic now and the doctor has advised to switch to Enzalutamide as it has fewer side effects.
Rodeoz15
in
Advanced Prostate Cancer
10 months ago
Food supplements I hope will help
Treated with IMRT radiation + Eligard +
Abiraterone
. PSA undetectable. Stopped
Abiraterone
due liver that hates it (liver is ok). Will try Nubeqa, and may switch to Orgovyx after Eligard runs out in December.
Treated with IMRT radiation + Eligard +
Abiraterone
. PSA undetectable. Stopped
Abiraterone
due liver that hates it (liver is ok). Will try Nubeqa, and may switch to Orgovyx after Eligard runs out in December.
Brad70
in
Advanced Prostate Cancer
10 months ago
Need inputs on Abi side-effects for bed-ridden patient
Last month, oncologist had said that he will start
Abiraterone
in case the trend is increasing and also that he needs to see the patient once. Does
Abiraterone
have any significant side-effects? My dad has been completely bed-ridden for over 2 years now.
Last month, oncologist had said that he will start
Abiraterone
in case the trend is increasing and also that he needs to see the patient once. Does
Abiraterone
have any significant side-effects? My dad has been completely bed-ridden for over 2 years now.
MadrasMarina
in
Advanced Prostate Cancer
10 months ago
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