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Finally, Real Promise' for Prostate Cancers With No Therapy20+-Month Improvement in Metastasis-Free Survival
Of those whose disease progressed, 80% of patients who were given placebo and 56% of patients who were given apalutamide received open-label
abiraterone
(Zytiga, Janssen-Cilag) for metastatic castrate-resistant prostate cancer.
Of those whose disease progressed, 80% of patients who were given placebo and 56% of patients who were given apalutamide received open-label
abiraterone
(Zytiga, Janssen-Cilag) for metastatic castrate-resistant prostate cancer.
Hidden
in
Advanced Prostate Cancer
6 years ago
ASCO Genitourinary Cancers Symposium (Xofigo - Radium-223 retreatment)
No concomitant cytotoxic agents were allowed; other concomitant agents (eg,
abiraterone
, enzalutamide) were allowed at investigator discretion. The primary objective was safety.
No concomitant cytotoxic agents were allowed; other concomitant agents (eg,
abiraterone
, enzalutamide) were allowed at investigator discretion. The primary objective was safety.
pjoshea13
in
Advanced Prostate Cancer
6 years ago
ASCO Genitourinary Cancers Symposium (Olaparib and Durvalumab in metastatic castrate-resistant prostate cancer (mCRPC))
Prior treatment with enzalutamide and/or
abiraterone
is required. D is given at 1500 mg iv q28 days + O 300 mg tablets po q12 hours. The primary endpoint is PFS. Core biopsies undergo mutational analysis.
Prior treatment with enzalutamide and/or
abiraterone
is required. D is given at 1500 mg iv q28 days + O 300 mg tablets po q12 hours. The primary endpoint is PFS. Core biopsies undergo mutational analysis.
pjoshea13
in
Advanced Prostate Cancer
6 years ago
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Adding PARP inhibitor (Olaparib) to the Standard Therapy (Zytiga/ADT/Prenosone)
He admitted they are real risks, but pointed out that they had the same concerns with adding docetaxel and
abiraterone
in STAMPEDE and LATITUDE trials which were proven wrong. PARP inhibitors are also "generally" well tolerated.
He admitted they are real risks, but pointed out that they had the same concerns with adding docetaxel and
abiraterone
in STAMPEDE and LATITUDE trials which were proven wrong. PARP inhibitors are also "generally" well tolerated.
snoraste
in
Advanced Prostate Cancer
6 years ago
FDA approves Abiraterone/prednisone
http://www.janssen.com/zytiga-
abiraterone
-acetate-plus-prednisone-approved-treatment-earlier-form-metastatic-prostate
http://www.janssen.com/zytiga-
abiraterone
-acetate-plus-prednisone-approved-treatment-earlier-form-metastatic-prostate
dockam
in
Advanced Prostate Cancer
6 years ago
I'm still going strong!
After a few weeks on Casodex, changed to
Abiraterone
, Goserlin (Zoladex). I have also had Radium 223. PSA fell initially to 0 then has risen slowly. Last reading 22. Most recent scans show no organ or soft tissue involvement. My consultant says that I am doing remarkably well.
After a few weeks on Casodex, changed to
Abiraterone
, Goserlin (Zoladex). I have also had Radium 223. PSA fell initially to 0 then has risen slowly. Last reading 22. Most recent scans show no organ or soft tissue involvement. My consultant says that I am doing remarkably well.
NiallMcC
in
Advanced Prostate Cancer
6 years ago
Gleason 9, PSMA shows positive lymph nodes, surgery (plus adjuvant adt & radiation) or just adt and radiation?
Since PSMA is so new, there's not a lot of studies on what to do with confirmed LN+ One other idea I had was to try and get
abiraterone
with the radiation and ADT like the STAMPEDE trial did in Dr James' July 2017 NEJM article.
Since PSMA is so new, there's not a lot of studies on what to do with confirmed LN+ One other idea I had was to try and get
abiraterone
with the radiation and ADT like the STAMPEDE trial did in Dr James' July 2017 NEJM article.
BruceSF
in
Advanced Prostate Cancer
6 years ago
Interesting PSA progression on STAMPEDE Zytiga (Abiraterone) trial.
Hi All A couple of months ago, I was asked if my PSA results were accurate, as I was quoting from memory, and it was 6 years ago. Anyway, today I got a definitive answer from my Oncologist, and I think they make interesting reading. First PSA test at doctors 12/11/2011 PSA 443.9 First PSA test at Oncology
Hi All A couple of months ago, I was asked if my PSA results were accurate, as I was quoting from memory, and it was 6 years ago. Anyway, today I got a definitive answer from my Oncologist, and I think they make interesting reading. First PSA test at doctors 12/11/2011 PSA 443.9 First PSA test at Oncology
TommyTV
in
Advanced Prostate Cancer
6 years ago
AR-V7, Zytiga(abiraterone) and Xtandi (enzalutamide)
According so some studies, 40-50 percent of patients receiving any of the above drugs do not respond well or develop resistance in about one year. I am curious to know if any of you who are already taken these drugs know whether you have been genetically screened for the presence or absence of AR-V7
According so some studies, 40-50 percent of patients receiving any of the above drugs do not respond well or develop resistance in about one year. I am curious to know if any of you who are already taken these drugs know whether you have been genetically screened for the presence or absence of AR-V7
Cmdrdata
in
Advanced Prostate Cancer
6 years ago
thoughts from a newby
Maybe a dropdown menu to help beginners, something like: Abbreviations etc Clinical name first (
abiraterone
), brand name second (Zytiga) varies by country PCa prostate cancer ADT androgen deprivation therapy mCRPC metastatic castration-resistant Prostate Cancer mets metastases bicalutamide
Maybe a dropdown menu to help beginners, something like: Abbreviations etc Clinical name first (
abiraterone
), brand name second (Zytiga) varies by country PCa prostate cancer ADT androgen deprivation therapy mCRPC metastatic castration-resistant Prostate Cancer mets metastases bicalutamide
rpol
in
Advanced Prostate Cancer
6 years ago
"Role of PARP Inhibitors Clarified in Prostate Cancer"
If these DNA repair alterations are present after treatment with
abiraterone
, docetaxel, or enzalutamide, there is a higher response rate to olaparib.
If these DNA repair alterations are present after treatment with
abiraterone
, docetaxel, or enzalutamide, there is a higher response rate to olaparib.
JLS1
in
Advanced Prostate Cancer
6 years ago
Abiraterone 500mg Daily
Hi guys, Due to the high expense of
Abiraterone
we are looking at my Father taking 500mg a day with food instead of 1000mg a day fasted state, now he taken 1000mg a day for a loading dose for one month. My Fathers oncologist is happy with this as well.
Hi guys, Due to the high expense of
Abiraterone
we are looking at my Father taking 500mg a day with food instead of 1000mg a day fasted state, now he taken 1000mg a day for a loading dose for one month. My Fathers oncologist is happy with this as well.
taylor123
in
Advanced Prostate Cancer
6 years ago
Looking to be aggressive, but in the right way?
I began treatment March with Casodex and a three month Lupron injection, and in August, replaced the Casodex with
Abiraterone
(1000 mg daily) to go with my three month Lupron injections.
I began treatment March with Casodex and a three month Lupron injection, and in August, replaced the Casodex with
Abiraterone
(1000 mg daily) to go with my three month Lupron injections.
Stickingaround1
in
Advanced Prostate Cancer
6 years ago
Useful video from last month's EMUC meeting in Barcelona.
Arm B will receive "androgen deprivation therapy + docetaxel +
abiraterone
acetate + prednisone". If that turns out to me superior - & why not?
Arm B will receive "androgen deprivation therapy + docetaxel +
abiraterone
acetate + prednisone". If that turns out to me superior - & why not?
pjoshea13
in
Advanced Prostate Cancer
6 years ago
Top doc's top story - STAMPEDE
., Lupron) +
abiraterone
(Zytiga) over ADT alone is the top story in prostate cancer for 2017. http://www.practiceupdate.com/expertopinion/3131/68/3 Alan
., Lupron) +
abiraterone
(Zytiga) over ADT alone is the top story in prostate cancer for 2017. http://www.practiceupdate.com/expertopinion/3131/68/3 Alan
AlanMeyer
in
Advanced Prostate Cancer
6 years ago
Merry Chemo Christmas!!
MO has stopped Cosodex and ruled out Enza or
Abiraterone
as there is no 'androgen axis'. He also noted that this is not behaving like 'normal PCa'. So I need to start chemo right away (first dose scheduled 29 Dec).
MO has stopped Cosodex and ruled out Enza or
Abiraterone
as there is no 'androgen axis'. He also noted that this is not behaving like 'normal PCa'. So I need to start chemo right away (first dose scheduled 29 Dec).
Hazard
in
Advanced Prostate Cancer
6 years ago
Is Abiraterone available before chemo on the NHS in the UK?
Hello, Just wondered if anyone could clarify whether Aberiaterone is available before chemo on the NHS in the UK? I am getting conflicting info on the web. Thanks in advance
Hello, Just wondered if anyone could clarify whether Aberiaterone is available before chemo on the NHS in the UK? I am getting conflicting info on the web. Thanks in advance
Clarejb
in
Advanced Prostate Cancer
6 years ago
Low testosterone / PSA failure / risk of death.
Given prolonged survival when
abiraterone
or docetaxel is added to ADT in men with castrate-sensitive metastatic PC and possibly localized high-risk PC provides a rationale supporting their use with ADT in men with low testosterone in the setting of a phase 2 trial.
Given prolonged survival when
abiraterone
or docetaxel is added to ADT in men with castrate-sensitive metastatic PC and possibly localized high-risk PC provides a rationale supporting their use with ADT in men with low testosterone in the setting of a phase 2 trial.
pjoshea13
in
Advanced Prostate Cancer
6 years ago
Thanks!
Possible
Abiraterone
+Olaparib trial participation if my bone biopsy is a match Changed my diet. Eliminated eggs, most dairy. Organic whenever possible. Can't do the vegan thing so just eating smarter. Lots of exercise. Strength and aerobic.
Possible
Abiraterone
+Olaparib trial participation if my bone biopsy is a match Changed my diet. Eliminated eggs, most dairy. Organic whenever possible. Can't do the vegan thing so just eating smarter. Lots of exercise. Strength and aerobic.
ewhite999
in
Advanced Prostate Cancer
6 years ago
Integrating evolutionary dynamics into treatment of mCRPC.
Two patients declined to continue GnRH suppression with Leuprolide (an ADT that is continuously administered as part of any
abiraterone
therapy) at months 17 and 20, respectively, but continue taking
abiraterone
.
Two patients declined to continue GnRH suppression with Leuprolide (an ADT that is continuously administered as part of any
abiraterone
therapy) at months 17 and 20, respectively, but continue taking
abiraterone
.
pjoshea13
in
Advanced Prostate Cancer
6 years ago
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